中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (35): 6466-6470.doi: 10.3969/j.issn.1673-8225.2011.35.002

• 骨科植入物 orthopedic implant • 上一篇    下一篇

局部应用伊班膦酸钠能加强内植物的早期固定：经X射线、组织学及生物力学结果验证

鲁秋东1，扈文海2，李成立2，胡彤宇2   

  1. 1天津宁河县人民医院，天津市  301500
    2 河北医科大学第三医院，河北省石家庄市  050010
  • 收稿日期:2011-03-08 修回日期:2011-06-13 出版日期:2011-08-27 发布日期:2011-08-27
  • 通讯作者: 扈文海，硕士，主任医师，教授，河北医科大学第三医院，河北省石家庄市 050010
  • 作者简介:鲁秋东，男，1980年生，天津市宁河县人，汉族，2010年河北医科大学毕业，主治医师，主要从事骨科方面的研究。

Local application of ibandronate enhances early fixation of implants X-ray, histomorphology and biomechanical pull-out tests 

Lu Qiu-dong1, Hu Wen-hai2, Li Cheng-li2, Hu Tong-yu2   

  1. 1People’s Hospital of Ninghe County, Tianjin  301500, China
    2Third Hospital of Hebei Medical University, Shijiazhuang  050010, Hebei Province, China
  • Received:2011-03-08 Revised:2011-06-13 Online:2011-08-27 Published:2011-08-27
  • Contact: Hu Wen-hai, Master, Chief physician, Professor, Third Hospital of Hebei Medical University, Shijiazhuang 050010, Hebei Province, China
  • About author:Lu Qiu-dong, Attending physician, People’s Hospital of Ninghe County, Tianjin 301500, China luqiudong_1980@163.com

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摘要：

背景：假体内植物的无菌松动已成为假体置换后最棘手的问题。
目的：观察局部应用伊班膦酸钠对内植物早期固定作用的影响。
方法：44只新西兰大白兔，建立兔双侧胫骨近端置入金属螺钉模型，每只兔左侧局部应用质量浓度为1 mg/L伊班膦酸钠(实验组)，右侧局部应用生理盐水(对照组)。
结果与结论：①X射线观察结果：造模后第2，4，8周时，实验组螺钉周围透光间隙较对照组明显变窄，且第4，8周时，实验组螺钉骨界面间新生骨较对照组明显增多。②组织学观察结果：第2周时，实验组界面间纤维膜厚度明显小于对照组(P < 0.001)，第4，8周时，实验组界面间新生骨量明显高于对照组(P < 0.001)。③生物力学打出实验测试结果：第4、8周时，实验组最大剪切强度明显大于对照组(P < 0.001)。结果表明局部应用伊班膦酸钠促进早期新骨形成，增强内植物早期固定作用，从而降低中后期内植物松动的可能。

关键词: 伊班膦酸钠, 无菌性松动, 纤维膜, 人工假体, 成骨细胞, 破骨细胞

Abstract:

BACKGROUND: The aseptic loosening of prosthesis has become one of the most obvious matters after operation of prosthesis replacement.  
OBJECTIVE: To verify the effect of ibandronate on early fixation of implants by local application.
METHODS: Forty-four Zelanian rabbits were used in the experiment. A standard animal model of the rabbits’ both tibia was embedded with metal screw into the proximal end. Ibandronate at 1 mg/L was sprinkled locally in the left tibia of every rabbit (experimental group), while saline solution was given in the right tibia (control group).
RESULTS AND CONCLUSION: ①X-ray showed that, the light-gap around the screw of the experimental group was remarkably narrower than that in control group in weeks 2, 4, 8 after model establishment; there were more new bones observed around the screw of experimental groups in weeks 4, 8 compared with control group. ②Histomorphology showed that in week 2, the width of the fiber membrane in control group was more thicker than in experimental group (P< 0.001); In weeks 4 and 8, the new bone mass (%) of experimental group was obviously higher than that of control group (P < 0.001). ③Biomechanical pull-out test showed that, the maximal shear strength (Pm) of experimental group was significantly higher than that of control group in weeks 4 and 8 (P < 0.001). These findings indicate that, local application of ibandronate solution can obviously promote new bone formation at the earlier period, improve early fixation of implants and decrease the incidence of aseptic loosening of prosthesis. 

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