中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (33): 6211-6215.doi: 10.3969/j.issn.1673-8225.2011.33.032

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

骨质疏松性牙周炎大鼠左归丸与雌激素治疗后颌骨结构和骨量的变化

李春年，李淑娟，杨冬茹，董福生，武明轩，刘  庆   

  1. 河北医科大学口腔医院口腔内科，河北省口腔医学重点实验室，河北省石家庄市
    050017
  • 收稿日期:2011-03-06 修回日期:2011-06-08 出版日期:2011-08-13 发布日期:2011-08-13
  • 通讯作者: 杨冬茹，主任医师，教授，河北医科大学口腔医院口腔内科，河北省口腔医学重点实验室，河北省石家庄市050017 yangdr@hebmu.edu.cn
  • 作者简介:李春年★，男，1979年生，2002年河北医科大学毕业，硕士，河北省承德市人，汉族，主治医师，主要从事牙周病的中西医结合治疗。 lchunnian@163.com
  • 基金资助:

    课题受河北省中医药管理局中医药、中西医结合科研计划课题(2009107)资助，课题名称：左归丸对实验性骨质疏松大鼠牙周炎的影响。

Changes in maxillary structure and bone mass in osteoporosis rats with experimental periodontitis after Zuogui pill and estrogen treatment

Li Chun-nian, Li Shu-juan, Yang Dong-ru, Dong Fu-sheng, Wu Ming-xuan, Liu Qing   

  1. Department of Oral Medicine, Stomatological Hospital of Hebei Medical University,  Hebei Key  Laboratory of Oral Medicine, Shijiazhuang 050017, Hebei Province, China
  • Received:2011-03-06 Revised:2011-06-08 Online:2011-08-13 Published:2011-08-13
  • Contact: Yang Dong-ru, Chief physician, Professor, Department of Oral Medicine, Stomatological Hospital of Hebei Medical University, Hebei Key Laboratory of Oral Medicine, Shijiazhuang 050017, Hebei Province, China yangdr@hebmu.edu.cn
  • About author:Li Chun-nian★, Master, Attending physician, Department of Oral Medicine, Stomatological Hospital of Hebei Medical University, Hebei Key Laboratory of Oral Medicine Shijiazhuang 050017, Hebei Province, China lchunnian@163.com
  • Supported by:

    a grant from Traditional Chinese Medicine and Integrated Traditional and Western Medicine Program of Hebei Provincial Bureau of Traditional Chinese Medicine, No.2009107*

PDF

301

被引次数

9

摘要：

背景：有研究表明经典补肾方剂左归丸可用于治疗绝经后女性的骨质疏松。
目的：观察骨质疏松性牙周炎大鼠左归丸与雌激素治疗后颌骨结构和骨量的变化。
方法：将SD大鼠麻醉下结扎上颌第一磨牙建立牙周炎模型、摘除大鼠卵巢建立骨质疏松模型，去势3个月后分别用左归丸和戊酸雌二醇治疗3个月。
结果与结论：左归丸、戊酸雌二醇治疗均能促进大鼠牙槽骨的新生，减轻牙周附着丧失(P < 0.05)，使破骨细胞数量减少 (P  < 0.05)，牙周组织中骨保护素水平升高(P < 0.01)，降低了血清中的碱性磷酸酶水平(P  < 0.01)。结果证实，左归丸、戊酸雌二醇在改善骨质疏松性牙周炎大鼠牙槽骨结构的基础上，促使颌骨骨量增加。

关键词: 骨质疏松, 牙周炎, 左归丸, 戊酸雌二醇, 组织形态学, 组织构建

Abstract:

BACKGROUND: Studies have shown that the classic kidney-tonifying prescription Zuogui pill can be used for treatment of osteoporosis in post-menopausal women.
OBJECTIVE: To observe the changes in maxillary structure and bone mass in osteoporosis rats with experimental periodontitis.
METHODS: Sprague-Dawley rat models of periodontitis were established by ligation of maxillary first molar under the anesthesia. Then osteoporosis was induced in these rat models by overiectomy. After 3 months, these rats were treated with Zuogui pill and estradiol valerate for 3 months.
RESULTS AND CONCLUSION: Both Zuogui pill and estradiol valerate promoted the neogenesis of alveolar bone, alleviated the inflammatory status of periodontal tissue (P < 0.05), reduced the osteoclasts (P < 0.05), elevated the osteoprotegerin level in the periodontal tissue (P < 0.01), and decreased the serum level of alkaline phosphatase (P < 0.01). These findings suggest that Zuogui pill and estrodiol valerate can improve the structure of alveolar bone and increase maxillary bone mass in osteoporosis rats with experimental periodontitis.

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