中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (33): 6099-6102.doi: 10.3969/j.issn.1673-8225.2011.33.005

• 骨组织构建 bone tissue construction • 上一篇    下一篇

原发性高血压模型大鼠颌骨骨量的吸收

张智轶1，王  敏2，郝  亮2，郭艳玲3，郭  玲2，罗  云2   

  1. 1重庆医科大学附属口腔医院修复科，重庆市 400015
    2口腔疾病研究国家重点实验室，四川大学华西口腔医院修复科，四川省成都市 610041
    3甘肃省卫生学校口腔教研室，甘肃省兰州市  730000
  • 收稿日期:2011-04-05 修回日期:2011-07-14 出版日期:2011-08-13 发布日期:2011-08-13
  • 通讯作者: 王敏，博士，教授，四川大学华西口腔医院修复科，四川省成都市 610041 zhangzhiyi521@tom.com
  • 作者简介:张智轶★，男，1983年生，重庆市人，汉族，2009年四川大学毕业，硕士，医师。 zhangzhiyi521@ tom.com 530102457@ qq.com
  • 基金资助:

    课题受四川省科技厅公益项目资助(2008FZ0174)，项目名称：原发性高血压与牙槽骨吸收的相关性研究。

Mandible resorption in a rat model of primary hypertension

Zhang Zhi-yi1, Wang Min2, Hao Liang2, Guo Yan-ling3, Guo Ling2, Luo Yun2   

  1. 1Department of Prosthodontics, the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing  400015, China
    2State Key Laboratory of Oral Diseases (Sichuan University), Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
    3Teaching and Research Section of Stomatology, Gansu Province Health School, Lanzhou 730000, Gansu Province, China
  • Received:2011-04-05 Revised:2011-07-14 Online:2011-08-13 Published:2011-08-13
  • Contact: Wang Min, Doctor, Professor, State Key Laboratory of Oral Diseases (Sichuan University), Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China zhangzhiyi521@tom.com
  • About author:Zhang Zhi-yi★, Master, Physician, Department of Prosthodontics, the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing 400015, China zhangzhiyi521@ tom.com 530102457@qq.com
  • Supported by:

    a grant from Public Welfare Program of Science and Technology Department of Sichuan Province, No. 2008FZ0174*

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332

被引次数

3

摘要：

背景：近年研究发现，高血压病患者中骨质疏松发病率较正常人群增高。
目的：观察原发性高血压与颌骨及牙槽骨吸收的关系。
方法：选用原发性高血压大鼠，随机分为模型组和给药组，正常大鼠作为对照组。模型组和对照组均进食未添加降压药物的普通标准饲料颗粒，给药组进食添加有降压药物的标准饲料颗粒。
结果与结论：模型组大鼠从10~22周龄收缩压逐渐上升，22周龄后血压趋于稳定。给药组和对照组血压较低且平稳。同一周龄大鼠血压值模型组>给药组>对照组(P < 0.01)。模型组和给药组大鼠下颌骨骨量均低于对照组(P < 0.01)。模型组骨皮质较薄，骨小梁稀疏、纤细、弯曲不整或断离，骨髓腔扩大，给药组骨质病理变化程度较模型组减轻。结果证实，血压升高可引起原发性高血压大鼠下颌骨骨量减少，使骨小梁变细、排列紊乱，从而增加牙槽骨吸收的风险。

关键词: 颌骨, 骨量, 原发性高血压, 骨密度, 骨吸收, 组织构建

Abstract:

BACKGROUND: Recent studies have shown that osteoporosis incidence is higher in hypertension patients than in healthy population.
OBJECTIVE: To investigate the relationship between primary hypertension and mandible resorption.
METHODS: Primary hypertension rats were randomly divided into a model group and an administration group. Normal rats served as controls. The model and control group rats were given standard animal feeds without hypotensive drugs. The administration group rats were given standard animal feeds with hypotensive drugs.
RESULTS AND CONCLUSION: The blood pressure of model group rats was gradually increased from 10-22 weeks and tended to stable after 22 weeks. The blood pressure of the administration and control groups was low and stable. For the same age rats, the blood pressure was highest in the model group, followed by the administration group, and lastly the control group (P < 0.01). Mandible mass was significantly lower in the model and administration groups than in the control group (P < 0.01). In the model group, the cortical bone was thinner, with sparse, thin or broken trabecula and bone marrow cavity was enlarged. The pathological changes were alleviated in the administration group than in the model group. Results showed increased blood pressure can cause mandible reduction of rats with primary hypertension, which causes thinned and disordered bone trabecula and then increases the risk of frontal resorption.

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