中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4747-4750.doi: 10.3969/j.issn.1673-8225.2011.25.046

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    

冠心病患者国产与进口雷帕霉素支架置入后早期康复训练对炎性反应的影响

王  莉   

  1. 辽宁医学院附属第三医院康复科，辽宁省锦州市121000
  • 收稿日期:2010-12-16 修回日期:2011-03-08 出版日期:2011-06-18 发布日期:2014-01-10
  • 作者简介:王莉，女，1963年生，辽宁省锦州市人，汉族，副主任医师，主要从事神经、骨关节病康复的研究。 wanglijz@yahoo.com.cn

Effects of early rehabilitation training on inflammatory response of coronary heart disease patients following Partner or Cypher stent implantation

Wang Li   

  1. Department of Rehabilitation, Third Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China
  • Received:2010-12-16 Revised:2011-03-08 Online:2011-06-18 Published:2014-01-10
  • About author:Wang Li, Associate chief physician, Department of Rehabilitation, Third Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China wanglijz@yahoo.com.cn

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354

被引次数

3

摘要：

背景：冠心病患者支架置入后24 h可见血清炎症因子水平升高，但支架置入后长期的血清炎症因子水平变化报道尚不多见。
目的：观察冠心病国产雷帕霉素药物洗脱支架(Partner支架)和进口雷帕霉素药物洗脱支架(Cypher)置入后早期康复训练对血清炎症因子及患者生活质量的影响。
方法：收集辽宁医学院附属第三医院2007-01/2009-12心内科介入支架治疗急性心肌梗死患者108例。根据病变及经济情况将患者分为Partner组(n=58)和Cypher组(n=50)。征询患者及家属意见，对部分患者进行早期康复训练，Partner组和Cypher组分别为34例和28例，所有患者于支架置入前、置入后3，5周抽取空腹静脉血，检测血清白细胞介素18，C-反应蛋白，肿瘤坏死因子α水平。置入后5周应用WHOQOL-BRIEF量表评估患者生活质量。
结果与结论：未进行康复训练的Cypher组患者血清白细胞介素18，C-反应蛋白和肿瘤坏死因子α水平在置入前和置入后3，5周与未康复训练+Partner组相比，差异无显著性意义(P > 0.05)。患者支架置入后5周，康复训练+Partner/Cypher组患者世界卫生组织的简明QOL测定表评分均明显高于对应的未进行康复训练组(P < 0.05)。提示进行康复训练对2种支架置入的冠心病患者血清炎症因子水平无明显影响，但却对患者生活质量有明显改善作用。

关键词: 支架, 生物相容性, 冠心病, 炎症因子, 康复训练, 生活质量

Abstract:

BACKGROUND: Serum inflammatory factors levels are elevated after stent implantation during early stage, such as post-surgery 24 hours. However, little is known about long-term changes in serum inflammatory factors levels.
OBJECTIVE: To evaluate histocompatibility of Partner and Cypher drug-eluting stents by observing change of serum inflammatory factor levels in patients with coronary heart disease, and to compare the effects of early rehabilitation training on quality of life of patients with coronary heart disease following implantation of two different drug-eluting stents.
METHODS: Totally 108 patients with acute myocardial infarction (AMI) admitted in the Third Hospital of Liaoning Medical University from 2007 to 2009 were chosen. All patients were assigned to Partner (implantion) group (n=58) and Cypher (implantion) group (n=50). Among them, 34 cases in Partner (implantion) group and 28 cases in Cypher (implantion) group received early rehabilitation training. Levels of interleukin-18 (IL-18), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) in serum were determined before stent implantation, 3 and 5 weeks after stent implantation. Quality of life of patients was evaluated at 5 weeks after stent implantation.
RESULTS AND CONCLUSION: Serum levels of IL-18, CRP and TNF-α between the patients not receiving rehabilitation training in Cypher and Partner groups were similar. Which indicated histocompatibility of Cypher and Partner stents are excellent, and no histocompatibility difference was observed between two kinds of stents. Serum levels of IL-18, CRP and TNF-α in patients receiving Cypher and Partner stents implantation were not affected by rehabilitation training, while quality of life in patients were improved following rehabilitation training.

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