中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4679-4682.doi: 10.3969/j.issn.1673-8225.2011.25.029

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同生物材料构建血管支架的组织相容性

赵广建1，赵  耀2   

  1. 武警医学院附属医院，1医教部，2肾病科，天津市，300162
  • 收稿日期:2011-04-09 修回日期:2011-05-20 出版日期:2011-06-18 发布日期:2014-01-10
  • 作者简介:赵广建，男，1958年生，河北省魏县人，汉族，1980年解放军第四军医大学毕业，副教授，副主任医师，主要从事预防医学与皮肤病学方面的研究。 guangjianzhao@yahoo.cn

Histocompatibility of vascular stents constructed using different biomaterials

Zhao Guang-jian1, Zhao Yao2   

  1. 1Department of Medical Education, 2Department of Nephrology, Affiliated Hospital, Medical College of CAPF, Tianjin  300162, China
  • Received:2011-04-09 Revised:2011-05-20 Online:2011-06-18 Published:2014-01-10
  • About author:Zhao Guang-jian, Associate professor, Associate chief physician, Department of Medical Education, Affiliated Hospital, Medical College of CAPF, Tianjin 300162, China guangjianzhao@yahoo.cn

PDF

348

被引次数

8

摘要：

背景：组织工程支架已成为近年来研究的热点，不同材料构建的组织工程血管支架的特点各异，植入后的生物相容性、感染、再狭窄是临床上面临的难点与重要研究课题。
目的：文章综述了不同材料构建的组织工程血管支架的特点和生物相容性等的研究进展，以便寻找临床最佳的生物材料支架。
方法：应用计算机检索CNKI和PubMed数据库中2002-01/2010-12关于细菌生物膜耐药机制的文章，在标题和摘要中以“组织工程，血管支架，相容性，感染，再狭窄”或“Tissue engineering，stents，compatibility，infection，restenosis ”为检索词进行检索。选择文章内容与血管支架的特点和生物相容性相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到285篇文献，根据纳入标准选择23篇文章进行综述。
结果与结论：天然材料包含有生物信息(如特殊的氨基酸序列)，可促进细胞吸附或使细胞保留分化功能，人工合成材料的优点是它们的强度、降解速度、微结构和渗透性均可在生产过程中进行控制；若生物材料和高分子可降解材料相结合，将两者按照一定的方法组合构建成一种复合基质，发挥两者各自的优势，便能更好地满足血管组织工程的要求，构建出性能良好的组织工程化血管。

关键词: 组织工程, 血管支架, 相容性, 感染, 再狭窄

Abstract:

BACKGROUND: Tissue-engineered scaffold has become a research hotspot in recent years. Tissue-engineered vascular stents prepared by different biomaterials have their own characteristics. Post-implant biocompatibility, infection, and restenosis are the difficulties and important topics in clinic.
OBJECTIVE: To review the characteristics and biocompatibility of tissue-engineered vascular stents prepared by different biomaterials so as to find an ideal biomaterial stent in clinic.
METHODS: A computer based search of CNKI and PubMed was performed to find articles regarding biofilm resistance mechanisms published from 2002-01 to 2010-12. The keywords were “tissue engineering; stents; compatibility; infection, restenosis” in Chinese and English. Articles published recently or in authorized journals were preferred. Among 285 articles, only 23 met the requirement.
RESULTS AND CONCLUSION: Natural materials containing biological information (such as special amino acid sequence) can promote cell adhesion or maintain the ability of cell differentiation. However, the advantages of artificial materials are their strength, degradation rate, microstructure and permeability that can be controlled in the production process. If biomaterials can be combined with polymer degradable materials according to a certain method to construct a composite matrix, this kind of composite matrix can play their two advantages and will be able to better meet the requirements of vascular tissue engineering to build a tissue-engineered vessel with good performance.

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