中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4587-4590.doi: 10.3969/j.issn.1673-8225.2011.25.008

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性

郭  涛1，韩  志2，杨天府3，李玉宝4，苑天红5，肖  杰1，陈艺新1   

  1. 1贵阳市第四人民医院骨科，贵州省贵阳市  550002
    2贵阳中医学院，贵州省贵阳市  550002
    3四川大学华西医院骨科，四川省成都市  610041
    4四川大学分析测试中心，四川省成都市  610041
    5贵阳医学院，贵州省贵阳市  550004
  • 收稿日期:2011-03-03 修回日期:2011-05-07 出版日期:2011-06-18 发布日期:2014-01-10
  • 作者简介:郭涛☆，男，1971年生，湖北省老河口市人，汉族，2007年四川大学华西临床医学院毕业，博士，副主任医师，主要从事骨损伤修复及组织工程的研究。 guotao04b@sina.com

Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin

Guo Tao1, Han Zhi2, Yang Tian-fu3, Li Yu-bao4, Yuan Tian-hong5, Xiao Jie1, Chen Yi-xin1   

  1. 1Department of Orthopedics, Guiyang 4th People’s Hospital, Guiyang  550002, Guizhou Province, China
    2Guiyang College of Traditional Chinese Medicine, Guiyang  550002, Guizhou Province, China
    3Department of Orthopedics, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
    4Centre of Analysis and Determination, Sichuan University, Chengdu  610041, Sichuan Province, China
    5Guiyang Medical College, Guiyang  550004, Guizhou Province, China
  • Received:2011-03-03 Revised:2011-05-07 Online:2011-06-18 Published:2014-01-10
  • About author:Guo Tao☆, Doctor, Associate chief physician, Department of Orthopedics, Guiyang 4th People’s Hospital, Guiyang 550002, Guizhou Province, China guotao04b@sina.com

PDF

413

被引次数

15

摘要：

背景：以明胶为基体制备的组织工程支架材料具有良好的生物相容性和生物降解性能，但存在力学性能低，降解速率难以控制的缺陷。
目的：制备一种软骨组织工程支架材料多孔聚乙烯醇/明胶复合物，并检测其理化性能和生物相容性。
方法：采用乳化发泡法制备聚乙烯醇/明胶多孔支架，并通过电镜分析、力学测试、皮下植入实验，检测材料孔径和孔隙率、IR光谱、力学性能和生物相容性。
结果与结论：多孔材料内部呈三维网状多孔结构，孔径均匀，有相似的孔隙率61.8%，含水率44.6%，抗拉强度为(5.01±0.03) MPa，抗压强度为(1.47±0.36) MPa，有较好的力学性能，IR光谱分析表明材料内部结构均匀。皮下植入后，炎症反应逐渐减轻，囊壁逐渐变薄，并趋于稳定，提示多孔聚乙烯醇/明胶支架材料具有较好的生物相容性和力学性能。

关键词: 多孔聚乙烯醇, 明胶, 软骨组织工程, 支架, 复合材料

Abstract:

BACKGROUND: The tissue engineered scaffolds prepared with gelatin as base have good biocompatibility and biodegradability, but low mechanical properties and difficulty to control degradation rate are their shortcomings.
OBJECTIVE: To prepare a new type of composite scaffold material of polyvinyl alcohol/gelatin and to evaluate the biocompatibility of composite scaffold.
METHODS: New type composite materials (polyvinyl alcohol/gelatin) were prepared by foaming method. The pore size and porosity, IR spectroscopy, mechanical performance and biocompatibility were detected by using scanning electron microscope, mechanical test and subcutaneous implantation test.
RESULTS AND CONCLUSION: Composite materials (polyvinyl alcohol/gelatin) were three-dimensional porous structure. The pore size was even, and the porosity was 61.8%. The water content rate of the composite materials was 44.6%. The tensile strength was (5.01±0.03) MPa, and the compressive strength was (1.47±0.36) MPa. The new type composite materials have been proved to have good biocompatibility and biomechanical properties.

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