中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (8): 1475-1478.doi: 10.3969/j.issn.1673-8225.2011.08.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

生物材料复合支架与运动性关节软骨缺损的修复

王宏亮1，韩  东2   

  1. 1东北石油大学秦皇岛分校体育教学部，河北省秦皇岛市 066004
    2 燕山大学体育学院，河北省秦皇岛市  066004
  • 收稿日期:2010-11-03 修回日期:2011-01-13 出版日期:2011-02-19 发布日期:2011-02-19
  • 作者简介:王宏亮，男，1982年生，辽宁省人，汉族，哈尔滨师范大学体育科学学院毕业，讲师，主要从事体育教学与运动训练方面的研究。 capslock889@163.com

Biomaterial composite scaffolds in repair of sports-induced articular cartilage defects

Wang Hong-liang1, Han Dong2   

  1. 1Department of Physical Education, Qinghuangdao Branch of Northeast Petroleum University, Qinhuangdao  066004, Hebei Province, China
    2Institute of Physical Education, Yanshan University, Qinhuangdao  066004, Hebei Province, China
  • Received:2010-11-03 Revised:2011-01-13 Online:2011-02-19 Published:2011-02-19
  • About author:Wang Hong-liang, Lecturer, Department of Physical Education, Qinghuangdao Branch of Northeast Petroleum University, Qinhuangdao 066004, Hebei Province, China capslock889@163.com

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406

被引次数

9

摘要：

目的：探讨复合支架的组织工程学特性及其修复关节软骨缺损的性能评价。
方法：以“关节软骨、生物材料、工程软骨、复合材料、复合支架”为中文关键词，以“ tissue enginneering，articular cartilage，scaffold material”为英文关键词，采用计算机检索中国期刊全文数据库、PubMed数据库(1993-01/2010-11)相关文章。纳入复合支架材料-细胞复合物修复关节软骨损伤相关的文章，排除重复研究或Meta分析类文章。
结果：共入选18篇文章进入结果分析。复合支架是当前软骨组织工程中应用较多的支架，它是将具有互补特征的生物相容性可降解支架，按一定比例和方式组合，设计出结构与性能优化的复合支架。较单一支架材料具有显著优越性，具有更好的生物相容性和一定强度的韧性，较好的孔隙和机械强度。复合支架的制备不仅包括同一类生物材料的复合，还包括不同类别生物材料之间的交叉复合。可分为纯天然支架材料、纯人工支架材料以及天然与人工支架材料的复合等3类。
结论：复合支架使生物材料具有互补特性，一定程度上满足了理想生物支架材料应具有的综合特点，但目前很多研究仍处于实验阶段，还有一些问题有待于解决，如不同材料的复合比例、复合工艺等。

关键词: 关节软骨, 复合材料, 生物材料, 组织工程软骨, 复合支架

Abstract:

OBJECTIVE: To investigate the tissue engineering properties of the composite scaffold and its performance evaluation for the repair of articular cartilage defects.
METHODS: Using “articular cartilage, biological materials, engineering cartilage, composite materials, composite scaffold” in Chinese and “tissue engineering, articular cartilage, scaffold material” in English as the key words, a computer-based online search of China Academic Journal Full-text database and PubMed database (1993-01/2010-11) was performed. Articles about the composite scaffold-cell compound in the repair of articular cartilage injury, duplicated research or Meta analysis were excluded.
RESULTS: A total of 18 articles were involved in the analysis of results. Composite scaffolds have been widely used in cartilage tissue engineering, it is a biocompatible and biodegradable stent with complementary characteristics, to a composite scaffold of structure and performance optimization can be designed according to certain ratio and combinations. Composite scaffolds are superior to single scaffold, with better biocompatibility and certain toughness, good porosity and mechanical strength. Composite scaffolds include not only the same type of biomaterials, but also different types of biomaterials. Scaffolds can be divided into natural, artificial and compound of natural with artificial scaffolds.
CONCLUSION: The composite scaffolds exhibit complementary properties of biological materials, thus meeting the requirement for an ideal biomaterial scaffold to some extent, but a lot of researches are still at experimental stage, some problems need to be solved, such as the proportion of different composite materials and combination technique.

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