中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (8): 1402-1404.doi: 10.3969/j.issn.1673-8225.2011.08.017

• 药物控释材料 drug delivery materials • 上一篇    下一篇

谷维素-壳聚糖缓释微囊的制备

顾杰波，范春雷，胡林峰，李浩榕   

  1. 浙江中医药大学生命科学学院，浙江省杭州市  310053
  • 收稿日期:2010-11-23 修回日期:2010-12-20 出版日期:2011-02-19 发布日期:2011-02-19
  • 通讯作者: 范春雷，硕士，浙江中医药大学生命科学学院，浙江省杭州市 310053 snow@zjtcm.net
  • 作者简介:顾杰波，女，1985年生，浙江省杭州市人，汉族，2008年浙江中医药大学毕业，主要从事中药降血脂与抗动脉粥样硬化研究。 bbxmforever@163.com
  • 基金资助:

    浙江省科技计划项目(2006C33006)。

Preparation of oryzanol-chitosan microcapsules

Gu Jie-bo, Fan Chun-lei, Hu Lin-feng, Li Hao-rong   

  1. College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou  310053, Zhejiang Province, China
  • Received:2010-11-23 Revised:2010-12-20 Online:2011-02-19 Published:2011-02-19
  • Contact: Fan Chun-lei, Master, College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang Province, China snow@zjtcm.net
  • About author:Gu Jie-bo, College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang Province, China bbxmforever@163.com
  • Supported by:

    Science and Technology Planning Project of Zhejiang Province, China, No. 2006C33006*

PDF

708

被引次数

14

摘要：

背景：壳聚糖具有良好的生物相容性和生物可降解性，可作为优良的药物控缓释及靶向载体、黏膜吸附剂、吸收促进剂。目前市场上尚未见有关谷维素的缓释制剂，也未见相关的文献报道。
目的：考察谷维素-壳聚糖缓释微囊的制备工艺。
方法：采用凝聚法以自制离心筛制粒机制备了谷维素-壳聚糖缓释微囊，并考察了产品的载药量和包封率。
结果与结论：实验制备的谷维素-壳聚糖缓释微囊载药量为47.68%，包封率为76.45%，微囊大小均匀、光洁度与成形度好。凝聚法制备工艺简单易行，稳定，重现性好，结果说明，利用天然高分子多糖类物质壳聚糖来包封谷维素是切实可行的，谷维素-壳聚糖缓释微囊具有进一步开发和应用价值。

关键词: 谷维素, 壳聚糖, 海藻酸钠, 载药量, 包封率

Abstract:

BACKGROUND: Chitosan has a good biocompatibility and biodegradability; it can be used as excellent drug controlled release and targeting vector, mucosal absorbent, absorption enhancers. However, the oryzanol sustained-release formulation as well as related literature has not been reported on the market.
OBJECTIVE: To investigate the preparation of oryzanol-chitosan microcapsules.
METHODS: Oryzanol-chitosan microcapsules were prepared by using of self-made centrifugal sieve granulator under the guidance of coagulation method, and the drug loading and encapsulation efficiency were investigated.
RESULTS AND CONCLUSION: The microcapsules were in uniform size, good finish and shape, drug loading of 47.68%, entrapment efficiency of 76.45%. The coagulation method is simple, stable and good reproducible. The results show that it is practicable to encapsulate oryzanol by using of natural polymer polysaccharide chitosan. The oryzanol-chitosan microcapsules have further development and application value.

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