中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (6): 1111-1114.doi: 10.3969/j.issn.1673-8225.2011.06.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

诱导多潜能干细胞在再生医学中的应用

刘渔凯1，罗  虎1，李泽桂2   

  1. 解放军第三军医大学，1学员旅17队，2药学院生药学教研室，重庆市 400038
  • 收稿日期:2010-09-22 修回日期:2010-11-01 出版日期:2011-02-05 发布日期:2011-02-05
  • 通讯作者: 李泽桂，博士，教授，解放军第三军医大学药学院生药学教研室，重庆市400038 lizegui@tmmu.edu.cn
  • 作者简介:刘渔凯，男，1987年生，重庆市人，汉族，解放军第三军医大学临床医学八年制在读。 liuyukai12345678@163.com
  • 基金资助:

    第三军医大学创新基金资助项目(2007XG42)。

Application of induced pluripotent stem cells in regenerative medicine

Liu Yu-kai1, Luo Hu1, Li Ze-gui2   

  1. 1Trainees Brigade Team 17, Third Military Medical University of Chinese PLA, Chongqing  400038, China
    2Department of Pharmacognosy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2010-09-22 Revised:2010-11-01 Online:2011-02-05 Published:2011-02-05
  • Contact: Li Ze-gui, Doctor, Professor, Department of Pharmacognosy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing 400038, China lizegui@tmmu.edu.cn
  • About author: Liu Yu-kai, Trainees Brigade Team 17, Third Military Medical University of Chinese PLA, Chongqing 400038, China liuyukai12345678@163.com
  • Supported by:

     the Innovation Foundation of the Third Military Medical University of Chinese PLA, No. 2007XG42*

PDF

370

被引次数

5

摘要：

背景：传统的器官或者细胞移植存在严重的供体来源不足和免疫排斥问题以及伦理学障碍。诱导多潜能干细胞有着近乎胚胎干细胞的自我更新能力和分化潜能，而且还拥有与患者一致的遗传物质，避免了免疫排斥反应，其应用前景十分广阔。
目的：综述诱导多潜能干细胞在再生医学领域应用研究的现状。
方法：应用计算机检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)相关文章，检索时间为1997/2010，检索词为“induced pluripotent stem cell，diabetes，Parkinson’s disease，cardiovascular”，并限定文章语言种类为English。初检得到文献322篇，最终入选30篇文章进行综述。
结果与结论：疾病特异的诱导多潜能干细胞来源于患者本身，拥有与患者一致的遗传物质，既降低了移植后的免疫排斥，也避免了伦理学的问题。因此个体特异的诱导多潜能干细胞在再生医学领域有潜在的应用前景。

关键词: 诱导多功能干细胞, 糖尿病, 帕金森病, 心肌梗死, 再生医学

Abstract:

BACKGROUND: Traditional transplantation of organs and cells would induce immunologic rejection and have some problems such as ethics and shortage of donor. Induced pluripotent stem (iPS) cells have self-renewal ability and differentiational potential as embryonic stem cells, and have genetic materials identical to patients, which avoids immunologic rejection. Thus, its application is broad.
OBJECTIVE: To review the current research about the progress of iPS cells in regenerative medicine.
METHODS: The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) was retrieved by computer to search the correlative documents published between 1997 and 2010 with the key words of “induced pluripotent stem cell, diabetes, Parkinson’s disease, cardiovascular” in English. Totally 322 papers were primarily gotten. Finally, 30 papers were included.
RESULTS AND CONCLUSION: Patient-specific iPS cell is induced from the patients themselves, so that it has the same genetic material and reduces the possibility of immunologic rejection. It also avoids the ethics problem. Thus, iPS cells have very large potential and broad prospect.

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