中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (6): 1107-1110.doi: 10.3969/j.issn.1673-8225.2011.06.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗慢性肾脏疾病的可行性

周  敬1，2，潘兴华1，庞荣清1，蔡学敏1   

  1. 1解放军成都军区昆明总医院干细胞与组织器官工程研究中心，云南省昆明市650032
    2昆明医学院临床学院，云南省昆明市  650031
  • 收稿日期:2010-08-28 修回日期:2010-12-18 出版日期:2011-02-05 发布日期:2011-02-05
  • 通讯作者: 潘兴华，博士，主任医师，解放军成都军区昆明总医院干细胞与组织器官工程研究中心，云南省昆明市 650032 xinghuapan@yahoo.com.cn
  • 作者简介:周敬★，女，1980年生，重庆市人，汉族，昆明医学院在读硕士，医师，主要从事血液内科方面的研究。 zhoujwl@163.com
  • 基金资助:

    云南省自然科学基金重点项目资助(2003M0013Z)。

Feasibility of stem cells transplantation for the treatment of chronic renal disease

Zhou Jing1, 2, Pan Xing-hua1, Pang Rong-qing1, Cai Xue-min1   

  1. 1Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming  650032, Yunnan Province, China
    2Institute of Clinical Medicine, Kunming Medical College, Kunming  650031, Yunnan Province, China
  • Received:2010-08-28 Revised:2010-12-18 Online:2011-02-05 Published:2011-02-05
  • Contact: Correspondence to: Pan Xing-hua, Doctor, Chief physician, Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming 650032, Yunnan Province, China xinghuapan@yahoo.com.cn
  • About author:Zhou Jing★, Studying for master’s degree, Physician, Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming 650032, Yunnan Province, China; Institute of Clinical Medicine, Kunming Medical College, Kunming 650031, Yunnan Province, China zhoujwl@163.com
  • Supported by:

    Major Program of Natural Science Foundation of Yunnan Province, No. 2003M0013Z*

PDF

565

被引次数

7

摘要：

背景：慢性肾脏疾病的发病率呈逐年递增趋势，传统血液透析和同种异体肾移植仍是目前仅有的治疗选择。随着以干细胞为基础的再生医学研究的进展，有可能从干细胞的角度找到慢性肾病治疗的理想治疗措施。
目的：就不同来源干细胞治疗慢性肾脏的作用机制及临床应用的可能性等进行综述。
方法：应用计算机检索CNKI和PubMed数据库中2006-01/2009-12关于干细胞治疗慢性肾病的文章，在标题和摘要中以“胚胎干细胞；骨髓干细胞；诱导性多少能干细胞；慢性肾脏疾病”或“Embryonic stem cells; Bone marrow stem cells; induced pluripotent stem cells；chronic kidney disease”为检索词进行检索。选择文章内容与干细胞治疗慢性肾病相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到128篇文献，根据纳入标准选择30篇文章进行综述。
结果与结论：多种来源的干细胞具有向肾组织细胞分化的潜能，大量实验研究表明干细胞移植对急性肾损伤修复有积极作用，同时对于肾脏纤维化疾病、终末期肾病的治疗等也有相关研究报道。通过对干细胞相关特性的描述及干细胞治疗肾病的相关机制的研究，希望能通过新的方法治疗慢性肾病。

关键词: 胚胎干细胞, 骨髓干细胞, 诱导性多能干细胞, 慢性肾脏疾病, 血液透析

Abstract:

BACKGROUND: The incidence of chronic renal disease was an increasing trend year by year; the traditional hemodialysis and allograft renal transplantation are is still the only treatment option. With the development of stem cell-based regenerative medicine research, it is possible to find the ideal treatment of chronic renal disease from the perspective of stem cells.
OBJECTIVE: To review action mechanism and the possibility of clinical application in the treatment of chronic renal disease from different sources of stem cells.
METHODS: Articles addressing stem cells for the treatment of chronic renal disease were retrieved by computer in CNKI database and PubMed database from January 2006 to December 2009 with the key words of “embryonic stem cells, bone marrow stem cells, induced pluripotent stem cells, chronic kidney disease” in Chinese or “embryonic stem cells, bone marrow stem cells, induced pluripotent stem cells, chronic kidney disease” in English in the title and abstract. The articles which contents are related to stem cell for the treatment of chronic renal disease were selected. The articles which published in recently literatures or the authoritative magazines were selected in the same field. A total of 128 literatures were obtained from the computer screen, and 30 documents of them were involved for summarization according to the inclusion criteria.
RESULTS AND CONCLUSION: Multiple sources of stem cells have the potential to differentiate to renal histiocyte. A large numbers of experimental studies have shown that stem cells transplantation on acute kidney injury repair has a positive effect. At the same time, studies for the treatment of renal fibrotic diseases and end stage renal disease have reported. Through the description of characteristics of stem cells and related mechanisms of stem cells for the treatment of renal disease, We hope there will be a new approach to the treatment of chronic renal disease.

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