中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9471-.doi: 10.3969/j.issn.1673-8225.2010.50.039

• 组织构建循证医学 • 上一篇    下一篇

亚洲人群白细胞介素8-251基因多态性与胃癌易感性的Meta分析

李光辉1，刘流2，刘浩1，刘熹1，刘进1，马立泰1   

  1. 四川大学华西医院，1骨科，2胃肠外科，四川省成都市 610041
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 通讯作者: 刘浩，博士生导师，四川大学华西医院骨科，四川省成都市 610041 liuhao6204@ 163.com
  • 作者简介:李光辉★，男，1983年生，山东省德州市人，汉族，四川大学华西临床医学院在读硕士，主要从事脊柱外科方面的研究。 skykisssea@163.com.

Interleukin-8-251 genetic polymorphisms and susceptibility of gastric cancer among Asians: A Meta-analysis

Li Guang-hui1, Liu Liu2, Liu Hao1, Liu Xi1, Liu Jin1, Ma Li-tai1   

  1. 1 Department of Orthopedics, 2 Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu  610041, Sichuan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • Contact: Liu Hao, Doctoral supervisor, Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China liuhao6204@163. com
  • About author:Li Guang-hui★, Studying for master’s degree, Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China skykisssea@163.com

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被引次数

1

摘要：

背景：炎性因素在胃癌发生过程中起重要作用，白细胞介素8在许多肿瘤组织均有明显表达。
目的：定量分析白细胞介素8-251基因位点多态性与亚洲人群胃癌易感性的关系。
方法：检索Medline，Embase和CNKI数据库，共纳入9篇以亚种人群为研究对象的病例对照研究。采用Stata 10.0统计软件对其结果进行定量分析，同时依据研究对象来源进行分层分析，综合评价白细胞介素8-251基因位点多态性与胃癌发生的关系。
结果与结论：白细胞介素8-251 TT基因位点及A基因位点在(AA+AT)在非中国亚洲人群的合并OR值及95%CI分别为[0.83, 0.71~0.96]和[1.13, 1.00~1.28]，具有显著性差异。白细胞介素8-251 AA基因位点及T基因位点(AT+TT)在亚洲人群的合并OR值及95%CI分别为[1.15, 0.91~1.45]和[0.99, 0.90~1.07]，均无显著性差异。白细胞介素8-251 TT基因位点和A基因位点在(AA+AT)在中国人群的合并OR值及95%CI分别为[1.02, 0.85~1.22]和[1.00, 0.87~1.15]，均无显著性差异。因此，白细胞介素8-251基因多态性与非中国亚洲人群胃癌易感性有关。携带白细胞介素8-251 A基因位点的非中国亚洲人群可能是胃癌高危人群，而携带TT等位基因的非中国亚洲人群可能是胃癌的低危人群。

关键词: 胃癌, 白细胞介素8, 基因多态性, 易感性, Meta分析

Abstract:

BACKGROUND: Inflammatory factors play an important role in gastric cancer. Interleukin 8 (IL-8) can be found in many tumor tissues. 
OBJECTIVE: To quantitative analyze the relationship between IL-8-251 genetic polymorphisms and susceptibility of gastric cancer.
METHODS: Medline, Embase and CNKI databases were searched and 9 case-control studies among Asians were included. Stata 10.0 software was used to quantitatively analyze the relationship between IL-8 genetic polymorphisms and risk of gastric cancer. At the same time, stratified analysis was made according to participants from different areas of Asian countries.
RESULTS AND CONCLUSION: The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype (AA+AT) among non-Chinese Asians were [0.83, 0.71-0.96] and [1.13, 1.00-1.28], they reached statistical significance. The combined OR and 95% CI for IL-8-251 AA genotype and T carrier genotype (AA+AT) among Asians were [1.15, 0.91-1.45] and [0.99, 0.90-1.07], they did not reach statistical significance. The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype (AA+AT) among Chinese were [1.02, 0.85-1.22] and [1.00, 0.87-1.15], they did not reach statistical significance. IL-8-251 genetic polymorphisms might be correlated with susceptibility of gastric cancer among non-Chinese Asians. Non-Chinese Asians with A carrier genotype (AA+AT) might be at high risk of gastric cancer development. In contrast, non-Chinese Asians with TT genotype might be at low risk of gastric cancer development.

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