中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9409-.doi: 10.3969/j.issn.1673-8225.2010.50.025

• 组织构建学术探讨 • 上一篇    下一篇

骨形态发生蛋白与骨质疏松症

黄宏兴，王广伟   

  1. 广州中医药大学附属骨伤科医院骨科，广东省广州市  510240
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 通讯作者: 王广伟，广州中医药大学在读硕士，广州中医药大学附属骨伤科医院，广东省广州市 510240 wgw619.2004@163.com
  • 作者简介:黄宏兴，男，1962年生，广东省广州市人，汉族，广州中医药大学毕业，教授，主要从事骨质疏松症方面研究。 gzhhx@126.com

Bone morphogenetic proteins and osteoporosis

Huang Hong-xing, Wang Guang-wei    

  1. Department of Orthopaedics, Affiliated Orthopaedics and Traumatology Hospital of Guangzhou University of Chinese Medicine, Guangzhou  510240, Guangdong Province, China
  • Online:2010-12-10 Published:2010-12-10
  • Contact: Wang Guang-wei, Studying for master’s degree, Department of Orthopaedics, Affiliated Orthopaedics and Traumatology Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong Province, China wgw619.2004@163.com
  • About author:Huang Hong-xing, Professor, Department of Orthopaedics, Affiliated Orthopaedics and Traumatology Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510240, Guangdong Province, China gzhhx@126.com

PDF

352

被引次数

20

摘要：

背景：骨形态发生蛋白能够诱导骨髓间质充质细胞分化为成骨细胞或成软骨细胞，并能够抑制破骨细胞活性，为治疗骨质疏松症开辟了一条新的途径。

目的：综述骨形态发生蛋白与骨质疏松症的研究进展，以便寻求有效控制手段，指导临床合理用药和新药开发。

方法：应用计算机检索CNKI和PubMed数据库中1995-01/2010-06关于骨形态发生蛋白及骨质疏松症的相关文章，检索词分别为“骨形态发生蛋白；细胞因子；骨；骨质疏松症”和“bone morphogenetic protein；cytokines；bone；osteoporosis”，语言分别设定为中文和英文。选择内容与骨形态发生蛋白和骨质疏松症相关的文章，同一领域文献则选择近期发表或发表在权威杂志文章，排除重复研究或Meta分析类文章。 

结果与结论：收集到287篇相关文献，排除不符合标准的文献，共纳入30篇符合标准的文献。经分析得出以下结论：骨形态发生蛋白促进骨髓间质细胞向成骨细胞方向转化，有利于更合理选择临床用药，有效地预防骨质疏松的进展。骨形态发生蛋白能够明显促进成骨活性，但其作用机制尚未完全清楚，有可能是多因素共同的协同作用，通过该方面的机制研究可指导临床用药和新药开发。

关键词: 骨形态发生蛋白, 细胞因子, 骨, 骨质疏松症, 文献综述

Abstract:

BACKGROUND: Bone morphogenetic proteins (BMPs) can induce bone marrow stromal cells differentiate into osteoblasts or chondrocytes, and inhibit osteoclast activity, which opens up a new way for the treatment of osteoporosis.
OBJECTIVE: To explore an effective means of controlling osteoporosis and make guidance for clinical drug administration and new medicine development by summarizing research progress of BMPs and osteoporosis. 
METHODS: Articles published in CNKI and Pubmed databases were searched by computer with key words of “bone morphogenetic protein, cytokines, bone, osteoporosis” in both Chinese and English from January 1995 and June 2010. Articles in the same circle published in the authoritative journals or recently published were included. Repetitive study or Meta analysis was excluded.
RESULTS AND CONCLUSION: Among 287 articles, 30 were included in the final analysis. BMPs promote bone marrow stromal cells differentiate into osteoblasts, this finding is benefit for reasonable choice for clinical medicine, and effectively prevent osteoporosis. BMPs can obviously promote bone activity, but its mechanism is not entirely clear, there may be more common factors of synergy. The study of mechanism and development provides guidelines for clinical drug application and new medicine development.

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