中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (43): 8090-8094.doi: 10.3969/j.issn.1673-8225.2010.43.028

• 骨与关节综述 bone and joint review • 上一篇    下一篇

骨科植入物表面细菌生物膜形成及植入物表面的抗菌改性

潘张翼，严  杰，曹  聪，董宇启   

  1. 上海交通大学医学院附属仁济医院，上海市 200001
  • 出版日期:2010-10-22 发布日期:2010-10-22
  • 通讯作者: 董宇启，硕士生导师，主任医师，教授，上海交通大学医学院附属仁济医院，上海市 200001 dyq001@gmail.com
  • 作者简介:潘张翼★，男，1986年生，上海市人，汉族，上海交通大学医学院在读硕士。 panzhangyi1109@126.com

Bacteria biomembrane formation and anti-bacterial surface modification of implants

Pan Zhang-yi, Yan Jie, Cao Cong, Dong Yu-qi   

  1. Renji Hospital, Shanghai Jiao Tong University Medical School, Shanghai  20001, China
  • Online:2010-10-22 Published:2010-10-22
  • Contact: Dong Yu-qi, Master’s supervisor, Chief physician, Professor, Renji Hospital, Shanghai Jiao Tong University Medical School, Shanghai 20001, China dyq001@gmail.com
  • About author:Pan Zhang-yi★, Studying for master’s degree, Renji Hospital, Shanghai Jiao Tong University Medical School, Shanghai 20001, China panzhangyi1109@126.com

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766

被引次数

13

摘要：

背景：近来大量研究证实，骨科植入物感染与植入材料表面形成细菌生物膜有关。由于全身应用抗生素的效果不甚理想，加之不良反应较大，所以应选择在植入物局部采用与细菌生物膜黏附释放机制针锋相对的抗感染手段。
目的：探讨植入物术后易感及耐药因素，并结合此因素介绍近年来逐渐被接受的各种抗菌涂层的效果和机制。
方法：检索Scopus数据库、中国科技期刊数据库（重庆维普）1990-01/2010-01有关骨科植入物术后感染，细菌生物膜及植入物表面抗菌改性相关研究。
结果与结论：在植入物表面生物相容性，耐磨耐腐蚀性研究进展的同时，抗菌性的研究也在进行。植入物表面抗菌改性的理念被广泛接受。可以说细菌的“零黏附”即是抗菌改性的终极目标。可是虽然各种抗菌涂层的研究繁多，大多都集中于体外实验阶段，相关动物实验甚至体内实验研究甚少。所以现今的理念依旧停留于植入物周围的机体自身免疫防御才是主要的抗感染机制。故加强植入物抗菌方面的生物学研究迫在眉睫，既不影响骨性融合又对周围组织影响微小的抗菌涂层可能就是今后研究方向。

关键词: 细菌生物膜, 植入物, 感染, 表面改性, 综述文献, 骨科植入物

Abstract:

BACKGROUND: A large number of studies have demonstrated that orthopedic implant infection is related to bacteria biomembrane on the surface of materials. As the effect of general antibiotic is not favorable and the adverse effect is great, anti-infection method with opposing mechanism of bacteria biomembrane attachment release should be used.
OBJECTIVE: To explore predisposing factor and drug resistance factor following implanting and investigate effect of various antibiosis coating.
METHODS: A computer-based online search of Scopus database and Vip Chinese Periodical Database was performed for articled published between January 1990 and January 2010 related to infection following implant implantation, bacteria biomembrane and surface modification of implants.
RESUTLS AND CONCLUSION: The studies on the biocompatibility, wear-resisting and anti-corrosivity on the surface modification of implants are conducted, as well as the antibiosis. The idea of anti-bacterial surface modification of implants is widely accepted. It can be said that the "zero adhesion" of the bacteria is the ultimate goal of antibacterial modification. Although there are numerous studies of various anti-bacterial coating, the majority of them have focused on the pilot phase in vitro, related in vivo animal experiments are few. The immune defense mechanism of the body around the implant has been considered to play a major role in the implant infections. Therefore, the imminent problem requires further investigation to enhance the study on antibiotic modification with little effect on the bone fusion and the surrounding structures.

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