中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (20): 3740-3743.doi: 10.3969/j.issn.1673-8225.2010.20.031

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

机械生长因子对骨骼肌卫星细胞的调控

孙婧瑜，陆耀飞   

  1. 上海体育学院运动科学学院，上海市  200438
  • 出版日期:2010-05-14 发布日期:2010-05-14
  • 作者简介:孙婧瑜，女，1985年生，黑龙江省哈尔滨市人，汉族，上海体育学院在读硕士，主要从事运动损伤的分子机制研究。 jingyusun@126.com。

Regulation effect of mechano growth factor on skeletal muscle satellite cells

Sun Jing-yu, Lu Yao-fei   

  1. Institute of Sports Science, Shanghai University of Sports, Shanghai  200438, China
  • Online:2010-05-14 Published:2010-05-14
  • About author:Sun Jing-yu, Studying for master’s degree, Institute of Sports Science, Shanghai University of Sports, Shanghai 200438, China jingyusun@126.com

PDF

623

被引次数

6

摘要：

背景：机械生长因子作为胰岛素样生长因子1的一个亚型，有促进肌卫星细胞增殖，抑制分化的功能，因此利用外源性机械生长因子类物质对卫星细胞进行干预，并对其调控的分子机制进行研究，可以为骨骼肌疾病的临床治疗及组织工程学的研究提供新的思路。
目的：综合分析机械生长因子对骨骼肌卫星细胞的调控及其治疗作用。
方法：采用计算机检索中国期刊全文数据库及PubMed数据库1995/2009相关文献，中文检索词为“机械生长因子，骨骼肌卫星细胞”；英文检索词为“MGF”。纳入标准：具有原创性的研究论文，其研究目的或方法具有代表性。排除标准：重复性研究及与课题相关性较弱的文献。
结果与结论：机械生长因子有激活肌卫星细胞，促进细胞增殖，抑制肌管融合及促进卫星细胞迁移的功能。机械生长因子对骨骼肌损伤修复、神经损伤修复及心肌梗死治疗等方面有积极的临床意义。外源性机械生长因子类物质对肌组织修复、再生方面的作用，有可能为运动损伤的康复治疗开辟新的途径，并且对细胞移植具有一定的临床意义。

关键词: 机械生长因子, 骨骼肌卫星细胞, 表达, 增殖V迁移, 综述文献

Abstract:

BACKGROUND: The mechano growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), is involved in tissue repair and adaptation. Therefore, the application of exogenous MGF on interfering satellite cells and regulating molecular mechanism provides a new idea for treating muscle damage.
OBJECTIVE: To analyze the regulation of MGF on skeletal muscle satellite cells and its clinical effects.
METHODS: The relevant articles between 1995 and 2009 were retrieved from PubMed and CNKI database using key words of “mechano growth factor; skeletal muscle satellite cells”, and restricting the language as English and Chinese by computer. The original articles with representation in the objectives or methods were included, and the repetitiveness or unrelated papers were excluded.
RESULTS AND CONCLUSION: The MGF could activate skeletal muscle satellite cells, promote cells proliferation, inhibit myotube integration and facilitate the migration of satellite cells, which had positive clinical effect on skeletal muscle repair, nerve repair and the treatment of myocardial infarction. The effects of exogenous MGF on promoting regeneration and repairing muscle tissue injury may open up a new avenue for sports damage, as well as exhibit an important role in satellite cell transplantation.

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