中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (18): 3369-3372.doi: 10.3969/j.issn.1673-8225.2010.18.034

• 器官移植综述 organ transplantation review • 上一篇    下一篇

膝关节半月板损伤的修复：异种异体及组织工程半月板移植替代治疗

王泽锦1,2，黄华扬1，李凭跃1，张  涛1   

  1. 1解放军广州军区广州总医院骨科医院骨病关节科，广东省广州市    510010； 2广州医学院研究生处2007级研究生班，广东省广州市     510182
  • 出版日期:2010-04-30 发布日期:2010-04-30
  • 通讯作者: 黄华扬，硕士，主任医师，硕士生导师，广州军区总医院骨科医院骨病关节科主任，广东省广州市 510010 johnhzy@sina.com
  • 作者简介:王泽锦★，男，1982年生，广东省揭阳市人，汉族，广州医学院在读硕士，主要从事骨关节科的基础与临床研究。 samwang19@126.com

Meniscus injury repair by xenogenic or tissue-engineered meniscus replacement therapy

Wang Ze-jin 1, 2, Huang Hua-yang1, Li Ping-yue1, Zhang Tao1   

  1. 1 Department of Orthopedic Joint, Orthopedics Hospital of Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou   510010, Guangdong Province, China; 2 Department of Postgraduate, Guangzhou Medical College, Guangzhou   510182, Guangdong Province, China
  • Online:2010-04-30 Published:2010-04-30
  • Contact: Huang Hua-yang, Master, Chief physician, Master’s supervisor, Department of Orthopedic Joint, Orthopedics Hospital of Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China johnhzy@sina.com
  • About author:Wang Ze-jin★, Studying for master’s degree, Department of Orthopedic Joint, Orthopedics Hospital of Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China; Department of Postgraduate, Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China samwang19@126.com

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摘要：

背景：半月板在膝关节运动性损伤中十分常见，因其血供特点，严重的半月板毁损性损伤治疗一直是临床的难题。如何有效修复半月板损伤防止后期膝关节骨性关节炎的发生，是很多学者一直努力解决的问题。
目的：就半月板损伤修复及严重半月板破裂损伤移植替代治疗情况进行综述。
方法：由第一作者检索中国知网(www.cnki.net)及Medline数据库(www.pubmed.com) 2000-01/2009-03有关半月板损伤修复及严重半月板破裂损伤移植替代治疗的文章，中文检索词为“半月板，修复，移植替代治疗”，英文检索词为“meniscus，repair，ransplanted replacement therapy”。排除研究目的与课题无关的文章以及重复研究，最后纳入29篇文献作进一步分析。
结果与结论：目前半月板损伤治疗方法多种多样，严格掌握适应证，选择适当的半月板修复方法显得尤其重要。异种异体半月板移植及组织工程半月板修复为半月板缺损尤其是无血管区的修复开辟了新的途径，然而此两种方法尚需在免疫学、流行病学、解剖学、生物力学及临床效果等方面加以研究验证。

关键词: 半月板, 损伤, 修复, 组织工程, 移植替代治疗, 综述文献

Abstract:

BACKGROUND: Meniscus injury is a common sports injury of knee joint. Severe meniscus injury is difficult for clinical treatment due to the blood supply features. Effective repair of meniscus injury can prevent osteoarthritis of knee joint.
OBJECTIVE: To review meniscus injury repair and transplantation replacement treatment of meniscus injury.
METHODS: A computer-based online search of CNKI (www.cnki.net) and Medline database (www.pubmed.com) was performed for related articles published between January 2000 and March 2009, with the keywords “meniscus, repair, transplanted replacement therapy” in Chinese and English. Unrelated and repetitive studies were excluded. A total of 29 articles were included.
RESULTS AND CONCLUSION: There are a number of treatment for meniscus injury, and indications and appropriate repair methods are very important. Xenogenic meniscus transplantation and tissue-engineered meniscus provide novel approach for meniscus injury repair, in particular the repair of avascular zone. However, the two methods require validation of immunology, epidemiology, anatomy, biomechanics, and clinical effect.

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