中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 549-551.doi: 10.3969/j.issn.1673-8225.2010.03.041

• 生物材料综述 biomaterial review • 上一篇    下一篇

肝细胞微囊化技术理论进展与临床应用

王加祥，韩宝三，吴旭波，余松林，黄  芳，匡  杰，彭承宏   

  1. 上海交通大学医学院瑞金医院，上海市  200025
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 彭承宏，博士，教授，上海交通大学医学院瑞金医院，上海市 200025 chhpeng@188.com
  • 作者简介:王加祥★，男，1979年生，江苏省盐城市人，汉族，上海交通大学医学院在读硕士，主要从事活体肝移植的临床及基础研究。 13564064276@139.com
  • 基金资助:

    国家“十一五”高新技术研究发展计划－“863”项目(2008AA02Z417) *;上海市科委自然科学基金(07ZR14076) *;国家自然科学基金重点项目(20434030) *;国家自然科学基金(30672043, 30772105, 20074031, 30801107) ****;上海市教委科研创新项目(09YZ84)*

Physio-chemical progress and clinical application of microencapsulated hepatocytes

Wang Jia-xiang, Han Bao-san, Wu Xu-bo, Yu Song-lin, Huang Fang, Kuang Jie, Peng Cheng-hong   

  1. Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai   200025, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Peng Cheng-hong, Doctor, Professor, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China chhpeng@188.com
  • About author:Wang Jia-xiang★, Studying for master’s degree, Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China 13564064276@139.com
  • Supported by:

     the National High-Tech Research and Development Program (863 Program) in the Eleventh Five-Year Plan, No. 2008AA02Z417*; the Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality, No. 07ZR14076*; the Key Program of National Natural Science Foundation of China, No. 20434030*; the National Natural Science Foundation of China, No. 30672043*, 30772105*, 20074031*, 30801107*; Innovation Program of Shanghai Municipal Education Commission, No. 09YZ84*

PDF

880

被引次数

2

摘要：

肝细胞分离技术日趋成熟，肝细胞移植成为较热门的研究领域，但供体短缺和免疫排斥反应，制约了其广泛应用。肝细胞微囊化有助于为肝细胞移植的推广应用提供大量的具有高度活性和良好功能的肝细胞。文章就肝细胞微囊化技术及其应用进展进行综述，为肝细胞大规模、高活性体外培养及长期冻存提供了新的途径。

关键词: 微囊, 生物型人工肝, 肝细胞移植, 肝细胞, 综述文献

Abstract:

With the development of cell separation technique, hepatocyte transplantation becomes a hot topic; however, the application is limited by donor deficiency and immunological rejection. Microencapsulated hepatocytes contribute to the promotion and application for liver cell transplantation, for which provide a large amount of high activity and good function of liver cells. In this paper, liver cell microencapsulation technology and its progress in applications were reviewed, providing prospective way for large-scale and high-active culture in vitro and long-term cryopreservation.

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