中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (30): 4881-4888.doi: 10.12307/2024.647
• 骨与关节综述 bone and joint review • 上一篇 下一篇
熊 洋,周世博,俞 兴,毕连涌,杨济洲,王逢贤,曲 弋,杨永栋,赵丁岩,赵 赫,仇子叶,姜国正
收稿日期:
2023-08-07
接受日期:
2023-10-07
出版日期:
2024-10-28
发布日期:
2023-12-28
通讯作者:
俞兴,教授,博士生导师,主任医师 ,北京中医药大学东直门医院骨科,北京市 100700
作者简介:
熊洋,1988年生,土家族,2020年北京中医药大学博士毕业,2022年清华大学材料学院博士后出站,医学博士,医师,主要从事骨组织工程、脊柱脊髓损伤、椎间盘退变基础与临床研究。
周世博,1994年生,北京中医药大学在读医学博士,主要从事骨组织工程,脊柱脊髓损伤,椎间盘退变基础与临床研究。
基金资助:
Xiong Yang, Zhou Shibo, Yu Xing, Bi Lianyong, Yang Jizhou, Wang Fengxian, Qu Yi, Yang Yongdong, Zhao Dingyan, Zhao He, Qiu Ziye, Jiang Guozheng
Received:
2023-08-07
Accepted:
2023-10-07
Online:
2024-10-28
Published:
2023-12-28
Contact:
Yu Xing, Professor, Doctoral supervisor, Chief physician, Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
About author:
Xiong Yang, MD, Physician, Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Zhou Shibo, MD, Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Supported by:
摘要:
文题释义:
获得性异位骨化:异位骨化指机体在生理性软组织中出现成熟的骨组织,可累及肌肉、韧带、腱、膜及其他皮下结缔组织。由创伤性、神经源性及其他后天性原因导致异位骨化的发生称之为获得性异位骨化。它既是一种疾病,也是某些疾病中的一个病理过程,具体发病机制目前仍不清楚。
背景:异位骨化是一个动态发展的过程,临床中不同亚型的异位骨化具有不同病因或诱导因素,但在异位骨化中后期进展阶段又表现出相似的病理过程,其中由于创伤等因素引起的获得性异位骨化具有较高的发病率。
目的:对近年获得性异位骨化发生发展相关分子生物学机制研究进行综述。结果与结论:①获得性异位骨化的发生和发展是一个动态的过程,具有一定的隐匿性,因此该疾病的诊疗有一定的困难。②文章通过综述国内外相关文献,发现获得性异位骨化涉及骨形态发生蛋白、转化生长因子β、Hedgehog、Wnt及mTOR 共5条主要信号通路,同时在局部微环境中涉及到Runx2、血管内皮生长因子、缺氧诱导因子、成纤维细胞生长因子及Sox9共5项核心枢纽因子,核心机制可能是不同信号通路之间的相互作用,影响机体成骨细胞前体细胞、成骨细胞微环境以及与此相关的细胞因子,进而影响机体骨代谢并导致获得性异位骨化的发生。③未来可以以异位骨化相关单细胞的成骨内稳态为研究方向,以成骨细胞前体细胞-成骨微环境-信号通路及细胞因子作为研究要素,探索各部分要素在不同时空条件下的特征,比较不同种类、不同个体细胞成骨内稳态异同,从整体视角观察异位骨化分子信号网络调控机制,有利于未来临床防治异位骨化新方法的探究。④以中医药及靶向治疗为代表的治疗方法是近年的研究热点,如何将中医药与体内成骨稳态联系,并与靶向治疗相结合,也是未来研究方向之一。⑤目前获得性异位骨化的研究仍多限于基础实验研究,临床防治方法仍存在疗效不确切及不良反应明显等缺陷,相关靶向防治药物临床应用安全性及有效性仍有待验证,如何以基础实验研究为基础,结合发生发展机制,为临床防治提供新方向将是未来研究的重点。
https://orcid.org/0000-0001-9977-5866 (熊洋);https://orcid.org/0000-0003-1260-0807 (周世博);https://orcid.org/0000-0003-3598-3492 (俞兴)
中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程
中图分类号:
熊 洋, 周世博, 俞 兴, 毕连涌, 杨济洲, 王逢贤, 曲 弋, 杨永栋, 赵丁岩, 赵 赫, 仇子叶, 姜国正. 获得性异位骨化的分子生物学机制[J]. 中国组织工程研究, 2024, 28(30): 4881-4888.
Xiong Yang, Zhou Shibo, Yu Xing, Bi Lianyong, Yang Jizhou, Wang Fengxian, Qu Yi, Yang Yongdong, Zhao Dingyan, Zhao He, Qiu Ziye, Jiang Guozheng. Molecular biological mechanism of acquired heterotopic ossification[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(30): 4881-4888.
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1.1.7 检索策略 以PubMed数据库文献检索策略为例,见图1。
1.1.8 检索文献量 初步共检索到539篇文献。
1.3 文献质量评估及数据提取 共检索到539篇中英文文献,根据文章标题及摘要,排除研究目的不相符、重复报道及不具备参考意义的文献后,最终纳入文献131篇进行综述,其中中文数据库19篇、英文数据库112篇。中文作者文献共77篇,英文作者文献共54篇,文献检索流程见图2。
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文题释义:
获得性异位骨化:异位骨化指机体在生理性软组织中出现成熟的骨组织,可累及肌肉、韧带、腱、膜及其他皮下结缔组织。由创伤性、神经源性及其他后天性原因导致异位骨化的发生称之为获得性异位骨化。它既是一种疾病,也是某些疾病中的一个病理过程,具体发病机制目前仍不清楚。异位骨化是在机体生理性软组织中出现成熟的骨组织,可累及肌肉、韧带、腱、筋膜及其他皮下结缔组织。具有疾病和病理过程双重角色。早期症状多不明显,后期发展可出现局部红肿、疼痛、关节活动受限,部分病例或累及重要脏器危及生命。分子生物学是从分子水平研究生物大分子结构和功能进而阐释生命现象本质的科学。截至目前,与骨形态发生蛋白相关的信号通路被证实与异位骨化的形成存在某种联系,但是作用机制尚未完全清楚。因此从分子生物学水平尝试阐述异位骨化发生的病理过程,旨在为临床进一步研究异位骨化提供一定的借鉴。
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