[1] SU V, LAU AF. Connexins: mechanisms regulating protein levels and intercellular communication. FEBS Lett. 2014;588(8):1212-1220.
[2] YEAGER M, HARRIS AL. Gap junction channel structure in the early 21st century: facts and fantasies. Curr Opin Cell Biol. 2007;19(5):521-528.
[3] KELSELL DP, DUNLOP J, HODGINS MB. Human diseases: clues to cracking the connexin code. Trends Cell Biol. 2001;11(1):2-6.
[4] ZHENG H, LIU Y, XU D, et al. Inhibition of gap junction-mediated intercellular communication by Poly (I:C) in cultured human corneal fibroblasts. Curr Eye Res. 2020;45(9):1043-1050.
[5] JIANG J, HOAGLAND D, PALATINUS JA, et al. Interaction of α Carboxyl terminus 1 peptide with the connexin 43 carboxyl terminus preserves left ventricular function after ischemia-reperfusion injury. J Am Heart Assoc. 2019;8(16):e012385.
[6] BEYER EC, BERTHOUD VM. Gap junction gene and protein families: connexins, innexins, and pannexins. Biochim Biophys Acta Biomembr. 2018;1860(1):5-8.
[7] OYAMADA M, TAKEBE K, ENDO A, et al. Connexin expression and gap-junctional intercellular communication in ES cells and iPS cells. Front Pharmacol. 2013;4:85.
[8] NOORMAN M, VAN DER HEYDEN MA, VAN VEEN TA, et al. Cardiac cell-cell junctions in health and disease: electrical versus mechanical coupling. J Mol Cell Cardiol. 2009;47(1):23-31.
[9] SMYTH JW, SHAW RM. The gap junction life cycle. Heart Rhythm. 2012;9(1):151-153.
[10] SOLAN JL, LAMPE PD. Specific Cx43 phosphorylation events regulate gap junction turnover in vivo. FEBS Lett. 2014;588(8):1423-1429.
[11] OSHIMA A, TANI K, HIROAKI Y, et al. Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule. Proc Natl Acad Sci U S A. 2007;104(24):10034-10039.
[12] EPIFANTSEVA I, SHAW RM. Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomembr. 2018;1860(1):40-47.
[13] MARTINS-MARQUES TANIA, RIBEIRO-RODRIGUES TERESA, BATISTA-ALMEIDA DANIELA, et al. Biological functions of connexin43 beyond intercellular communication. Trends Cell Biol. 2019;29(10):835-847.
[14] BEYER EC, PAUL DL, GOODENOUGH DA. Connexin 43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987;105(6 Pt 1): 2621-2629.
[15] RUSIECKA OM, MONTGOMERY J, MOREL S, et al. Canonical and non-canonical roles of connexin43 in cardioprotection. biomolecules. 2020;10(9):1225.
[16] MÁRQUEZ-ROSADO L, SOLAN JL, DUNN CA, et al. Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues. Biochim Biophys Acta. 2012; 1818(8):1985-1992.
[17] BOENGLER K, ROHRBACH S, WEISSMANN N, et al. Importance of Cx43 for right ventricular function. Int J Mol Sci. 2021;22(3):987.
[18] UNE H, YAMASAKI R, NAGATA S, et al. Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination. J Neuroinflammation. 2021;18(1):126.
[19] GRUBER HE, MA D, HANLEY EN JR, et al. Morphologic and molecular evidence for gap junctions and connexin 43 and 45 expression in annulus fibrosus cells from the human intervertebral disc. J Orthop Res. 2001;19(5):985-989.
[20] BERKOVITZ BK, BECKER D. Detailed morphology and distribution of gap junction protein associated with cells from the intra-articular disc of the rat temporomandibular joint. Connect Tissue Res. 2003;44(1):12-18.
[21] 张婧.实验性咬合紊乱致大鼠TMJ髁突骨关节炎样变及Cx43半通道在关节软骨退变中的作用[D].西安:第四军医大学,2013.
[22] YANG Y, LIU W, WEI J, et al. Transforming growth factor-β1-induced N-cadherin drives cell-cell communication through connexin43 in osteoblast lineage. Int J Oral Sci. 2021;13(1):15.
[23] TALBOT J, BRION R, LAMORA A, et al. Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts. J Cell Physiol. 2018;233(2):946-957.
[24] TALBOT J, DUPUY M, MORICE S, et al. Antagonistic functions of connexin 43 during the development of primary or secondary bone tumors. Biomolecules. 2020;10(9):1240.
[25] 沈斌,韦卉,任茜,等.缝隙连接蛋白43与肿瘤关系的研究进展[J].医学综述,2017,23(20):4001-4006.
[26] KAR R, BATRA N, RIQUELME MA, et al.Biological role of connexin intercellular channels and hemichannels. Arch Biochem Biophys. 2012;524(1):2-15.
[27] LAIRD DW. Syndromic and non-syndromic disease-linked Cx43 mutations. FEBS Lett. 2014;588(8):1339-1348.
[28] MEŞE G, RICHARD G, WHITE TW. Gap junctions: basic structure and function. J Invest Dermatol. 2007;127(11):2516-2524.
[29] GOODENOUGH DA, PAUL DL. Gap junctions. Cold Spring Harb Perspect Biol. 2009;1(1):a002576.
[30] KANAPORIS G, MESE G, VALIUNIENE L, et al. Gap junction channels exhibit connexin-specific permeability to cyclic nucleotides. J Gen Physiol. 2008;131(4): 293-305.
[31] MCCAIN ML, DESPLANTEZ T, GEISSE NA, et al. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012;302(2):H443-H450.
[32] ALONSO F, KRATTINGER N, MAZZOLAI L, et al. An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc Res. 2010;87(1):166-176.
[33] 唐良虎,李德,杨大春,等.上调Cx43对心肌细胞间通讯及离子通道的影响[J].西部医学,2016,28(3):6.
[34] COTRINA ML, LIN JH, NEDERGAARD M. Adhesive properties of connexin hemichannels. Glia. 2008;56(16):1791-1798.
[35] LIN JH, TAKANO T, COTRINA ML, et al. Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J Neurosci. 2002;22(11):4302-4311.
[36] ELIAS LA, WANG DD, KRIEGSTEIN AR. Gap junction adhesion is necessary for radial migration in the neocortex. Nature. 2007;448(7156):901-907.
[37] 赵希伟,周佳伟,刘凯,等.连接蛋白43通过蛋白激酶A介导丝氨酸373调控脓毒症急性肺损伤肺泡Ⅱ型上皮细胞屏障功能的研究[J].中华危重症医学杂志(电子版),2021,14(5):355-361.
[38] NAGASAWA K, CHIBA H, FUJITA H, et al. Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. J Cell Physiol. 2006;208(1):123-132.
[39] HARRIS AL, BEVANS CG. Exploring hemichannel permeability in vitro. Methods Mol Biol. 2001;154:357-377.
[40] GUTSTEIN DE, MORLEY GE, TAMADDON H, et al.Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin 43. Circ Res. 2001;88(3):333-339.
[41] XING L, YANG T, CUI S, et al. Connexin hemichannels in astrocytes: role in CNS disorders. Front Mol Neurosci. 2019;12:23.
[42] KAMERITSCH P, POGODA K. The role of connexin 43 and pannexin 1 during acute inflammation. Front Physiol. 2020;11:594097.
[43] CALDER BW, MATTHEW RHETT J, BAINBRIDGE H, et al. Inhibition of connexin 43 hemichannel-mediated ATP release attenuates early inflammation during the foreign body response. Tissue Eng Part A. 2015;21(11-12):1752-1762.
[44] DOSCH M, ZINDEL J, JEBBAWI F, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife. 2019;8:e42670.
[45] WILLEBRORDS J, CRESPO YANGUAS S, MAES M, et al. Connexins and their channels in inflammation. Crit Rev Biochem Mol Biol. 2016;51(6):413-439.
[46] KELLEY N, JELTEMA D, DUAN Y, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20(13):3328.
[47] ZHOU KQ, GREEN CR, BENNET L, et al. The role of connexin and pannexin channels in perinatal brain injury and inflammation. Front Physiol. 2019;10:141.
[48] YANG Y, WANG H, KOUADIR M,et al. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 2019;10(2):128.
[49] PRICE GW, CHADJICHRISTOS CE, KAVVADAS P, et al. Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease. Cell Commun Signal. 2020;18(1):79.
[50] MUGISHO OO, GREEN CR, ZHANG J, et al. Connexin43 hemichannels: a potential drug target for the treatment of diabetic retinopathy. Drug Discov Today. 2019; 24(8):1627-1636.
[51] 薛俊杰,李婧瑜,张莉,等.缝隙连接蛋白43在骨关节炎软骨及细胞中表达及shRNA慢病毒载体的构建[J].中国组织工程研究,2020,24(23):3627-3635.
[52] 蔡正旭.由CX32和CX43组成的缝隙连接在癫痫发病中的作用及调控机制的实验研究[D].长春:吉林大学,2004.
[53] RODJAKOVIC D, SALM L, BELDI G. Function of connexin-43 in macrophages. Int J Mol Sci. 2021;22(3):1412.
[54] WILLEBRORDS J, MAES M, CRESPO YANGUAS S, et al.Inhibitors of connexin and pannexin channels as potential therapeutics. Pharmacol Ther. 2017;180:144-160.
[55] BOENGLER K, DODONI G, RODRIGUEZ-SINOVAS A, et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res. 2005;67(2):234-244.
[56] KOZORIZ MG, CHURCH J, OZOG MA, et al.Temporary sequestration of potassium by mitochondria in astrocytes. J Biol Chem. 2010;285(41):31107-31119.
[57] LI H, BRODSKY S, KUMARI S, et al. Paradoxical overexpression and translocation of connexin43 in homocysteine-treated endothelial cells. Am J Physiol Heart Circ Physiol. 2002;282(6):H2124-H2133.
[58] KIM SN, KWON HJ, IM SW, et al. Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Sci Rep. 2017;7(1):7159.
[59] BOENGLER K, SCHULZ R. Connexin 43 and mitochondria in cardiovascular health and disease. Adv Exp Med Biol. 2017;982:227-246.
[60] GADICHERLA AK, WANG N, BULIC M, et al. Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart. Basic Res Cardiol. 2017;112(3):27.
[61] WANG M, SMITH K, YU Q, et al. Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia/reperfusion injury. Basic Res Cardiol. 2019;115(1):1.
[62] GUO R, SI R, SCOTT BT, et al. Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells. Am J Physiol Cell Physiol. 2017; 312(4):C398-C406.
[63] BOENGLER K, HEUSCH G, SCHULZ R. Connexin 43 and ischemic preconditioning: effects of age and disease. Exp Gerontol. 2006;41(5):485-488.
[64] FERNANDEZ-SANZ C, RUIZ-MEANA M, CASTELLANO J, et al. Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes. Thromb Haemost. 2015;113(3):441-451.
[65] LIU D, GAO Y, LIU J, et al. Intercellular mitochondrial transfer as a means of tissue revitalization. Signal Transduct Target Ther. 2021;6(1):65.
[66] ISLAM MN, DAS SR, EMIN MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-765.
[67] YAO Y, FAN XL, JIANG D, et al. Connexin 43-mediated mitochondrial transfer of iPSC-MSCs alleviates asthma inflammation. Stem Cell Reports. 2018;11(5):1120-1135.
[68] GOLAN K, SINGH AK, KOLLET O, et al. Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. Blood. 2020;136(23):2607-2619.
[69] SANTANGELO L, GIURATO G, CICCHINI C, et al. The RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microrna sorting. Cell Rep. 2016;17(3):799-808.
[70] LIN YN, MESQUITA T, SANCHEZ L, et al. Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice. Eur Heart J. 2021;42(35):3558-3571.
[71] COLOMBO M, RAPOSO G, THÉRY C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255-289.
[72] SOARES AR, MARTINS-MARQUES T, RIBEIRO-RODRIGUES T, et al. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells. Sci Rep. 2015;5:13243.
[73] GADOK AK, BUSCH DJ, FERRATI S, et al. Connectosomes for direct molecular delivery to the cellular cytoplasm. J Am Chem Soc. 2016;138(39):12833-12840.
[74] MARTINS-MARQUES T, PINHO MJ, ZUZARTE M, et al. Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin. J Extracell Vesicles. 2016;5:32538.
[75] SMYTH JW, SHAW RM. Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep. 2013;5(3):611-618.
[76] BASHEER WA, XIAO S, EPIFANTSEVA I, et al. GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs. Circ Res. 2017; 121(9):1069-1080.
[77] JAMES CC, ZEITZ MJ, CALHOUN PJ, et al. Altered translation initiation of Gja1 limits gap junction formation during epithelial-mesenchymal transition. Mol Biol Cell. 2018;29(7):797-808.
[78] SALAT-CANELA C, SESÉ M, PEULA C, et al. Internal translation of the connexin 43 transcript. Cell Commun Signal. 2014;12:31.
[79] CHATTERJEE B, CHIN AJ, VALDIMARSSON G, et al. Developmental regulation and expression of the zebrafish connexin 43 gene. Dev Dyn. 2005;233(3):890-906.
[80] FU Y, ZHANG SS, XIAO S, et al. Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol. 2017;8:905.
[81] SHIMURA D, NUEBEL E, BAUM R, et al. Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. Elife. 2021;10:e69207. |