[1] MUNDY G, GARRETT R, HARRIS S, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286(5446):1946-1949.
[2] FENG C, XIAO L, YU JC, et al. Simvastatin promotes osteogenic differentiation of mesenchymal stem cells in rat model of osteoporosis through BMP-2/Smads signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24(1):434-443.
[3] SHAO PL, WU SC, LIN ZY, et al. Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells. Int J Mol Sci. 2019;20(3):506.
[4] XU R, SHI G, XU L, et al. Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity. J Tissue Eng Regen Med. 2018;12(5): 1209-1219.
[5] YU D, ZHAO D, YANG D, et al. Simvastatin promotes murine osteoclasts apoptosis in vitro through NFATc1 pathway. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39(6):672-678.
[6] SUTHANTHIRAN T, ANNAMALAI S, CHELLAPANDI S, et al. Gingival Crevicular Fluid Levels of RANKL and OPG After Placement of Collagen Membrane With Simvastatin in the Treatment of Intrabony Defects in Chronic Periodontitis. J Pharm Bioallied Sci. 2019;11(Suppl 2): S301-S304.
[7] SHAHEEN MY, BASUDAN AM, NIAZY AA, et al. Impact of single or combined drug therapy on bone regeneration in healthy and osteoporotic rats. Tissue Eng Part A. 2020. doi: 10.1089/ten.TEA.2020.0122.
[8] OZEÇ I, KILIÇ E, GÜMÜŞ C, et al. Effect of local simvastatin application on mandibular defects. J Craniofac Surg. 2007;18(3):546-550.
[9] KAMIŃSKA M, ALIKO A, HELLVARD A, et al. Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis. J Periodontol. 2019;90(6):637-646.
[10] GROVER HS, KAPOOR S, SINGH A. Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - A clinicobiochemical study. J Oral Biol Craniofac Res. 2016;6(2):85-92.
[11] BAHAMMAM MA, ATTIA MS. Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-α, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. J Immunol Res. 2018;2018:8481735.
[12] POSTON CJ, PIERCE TC, LI Y, et al. Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis. Oral Dis. 2016;22(5):438-444.
[13] NANTAVISAI S, RODPRASERT W, PATHANACHAI K, et al. Corrigendum to “Simvastatin enhances proliferation and pluripotent gene expression by canine bone marrow-derived mesenchymal stem cells (cBM-MSCs) in vitro” [Heliyon 5, (10), (October 2019), e02663]. Heliyon. 2019;5(11): e02805.
[14] ANAND K, SKETRIS I, ZHANG Y, et al. The Impact of US FDA and Health Canada Warnings Related to the Safety of High-dose Simvastatin. Drugs Real World Outcomes. 2017;4(4):215-223.
[15] CHEN PY, SUN JS, TSUANG YH, et al. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr Res. 2010;30(3):191-199.
[16] XU R, SHI G, XU L, et al. Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity. J Tissue Eng Regen Med. 2018;12(5): 1209-1219.
[17] DEREN ME, EHTESHAMI JR, DINES JS, et al. Simvastatin Exposure and Rotator Cuff Repair in a Rat Model. Orthopedics. 2017;40(2):e288-e292.
[18] HAMISHEHKAR H, EMAMI J, NAJAFABADI AR, et al. The effect of formulation variables on the characteristics of insulin-loaded poly(lactic-co-glycolic acid) microspheres prepared by a single phase oil in oil solvent evaporation method. Colloids Surf B Biointerfaces. 2009;74(1):340-349.
[19] LIU J, XU Y, WANG Y, et al. Effect of inner pH on peptide acylation within PLGA microspheres. Eur J Pharm Sci. 2019;134:69-80.
[20] XIONG Y, YU Z, LANG Y, et al. In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor--poly(lactic-co-glycolic-acid) microsphere. Drug Des Devel Ther. 2016;10:431-440.
[21] 李祥伟,张颖丽,林权,等.载辛伐他汀微球缓释软膏促进牙槽骨缺损修复的研究[J].北京口腔医学,2012,20(6):314-317.
[22] ZHU K, ZHAO F, YANG Y, et al. Effects of simvastatin-loaded PLGA microspheres on treatment of rats with intervertebral disk degeneration and on 6-K-PGF1α and HIF-1α. Exp Ther Med. 2020; 19(1):579-584.
[23] CHEN L, YANG G, CHU X, et al. Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated Controlled-Release Film-Coating. Pharmaceutics. 2019;11(2):80.
[24] KOVÁČIK A, KOPEČNÁ M, VÁVROVÁ K. Permeation enhancers in transdermal drug delivery: benefits and limitations. Expert Opin Drug Deliv. 2020;17(2):145-155.
[25] OGAWA Y, YAMAMOTO M, OKADA H, et al. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chem Pharm Bull (Tokyo). 1988; 36(3):1095-1103.
[26] MASAELI R, JAFARZADEH KASHI TS, DINARVAND R, et al. Preparation, Characterization and Evaluation of Drug Release Properties of Simvastatin-loaded PLGA Microspheres. Iran J Pharm Res. 2016; 15(Suppl):205-211.
[27] WANG X, QI F, XING H, et al. Uniform-sized insulin-loaded PLGA microspheres for improved early-stage peri-implant bone regeneration. Drug Deliv. 2019;26(1):1178-1190.
[28] YANG Y, SHEN L, YUAN F, et al. Preparation of sustained release capsules by electrostatic dry powder coating, using traditional dip coating as reference. Int J Pharm. 2018;543(1-2):345-351.
[29] HERRLICH S, SPIETH S, MESSNER S, et al. Osmotic micropumps for drug delivery. Adv Drug Deliv Rev. 2012;64(14):1617-1627.
[30] WANG CZ, WANG YH, LIN CW, et al. Combination of a Bioceramic Scaffold and Simvastatin Nanoparticles as a Synthetic Alternative to Autologous Bone Grafting. Int J Mol Sci. 2018;19(12):4099.
[31] CHOU J, ITO T, BISHOP D, et al. Controlled release of simvastatin from biomimetic β-TCP drug delivery system. PLoS One. 2013;8(1):e54676.
[32] XUE Y, WU M, LIU Z, et al. In vitro and in vivo evaluation of chitosan scaffolds combined with simvastatin-loaded nanoparticles for guided bone regeneration. J Mater Sci Mater Med. 2019;30(4):47.
[33] Montazerolghaem M, Engqvist H, Karlsson Ott M. Sustained release of simvastatin from premixed injectable calcium phosphate cement. J Biomed Mater Res A. 2014;102(2):340-347.
[34] 于祥茹,韩晓谦,程梁,等.载辛伐他汀PLGA/CPC支架材料复合BMSCs修复大鼠颅骨缺损的实验研究[J].口腔医学研究,2015, 31(10):1032-1036.
[35] ZHANG HX, ZHANG XP, XIAO GY, et al. In vitro and in vivo evaluation of calcium phosphate composite scaffolds containing BMP-VEGF loaded PLGA microspheres for the treatment of avascular necrosis of the femoral head. Mater Sci Eng C Mater Biol Appl. 2016;60:298-307.
[36] KANG Z, ZHANG X, CHEN Y, et al. Preparation of polymer/calcium phosphate porous composite as bone tissue scaffolds. Mater Sci Eng C Mater Biol Appl. 2017;70(Pt 2):1125-1131.
[37] YIN H, LI YG, SI M, et al. Simvastatin-loaded macroporous calcium phosphate cement: preparation, in vitro characterization, and evaluation of in vivo performance. J Biomed Mater Res A. 2012; 100(11):2991-3000.
[38] TAO Z, ZHOU W, JIANG Y, et al. Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats. J Biomater Appl. 2018; 33(1):3-10.
[39] MENG T, JIANG R, WANG S, et al. Corrigendum to “Stem Cell Membrane-Coated Au-Ag-PDA Nanoparticle-Guided Photothermal Acne Therapy”, Colloids and Surfaces B: Biointerfaces (2020) 192C/COLSUB_111145]. Colloids Surf B Biointerfaces. 2020;196:111314.
[40] IKEDA T, IKEDA K, YAMAMOTO K, et al. Fabrication and characteristics of chitosan sponge as a tissue engineering scaffold. Biomed Res Int. 2014;2014:786892.
[41] KOPECEK J. Hydrogel biomaterials: a smart future? Biomaterials. 2007;28(34):5185-5192.
[42] DYONDI D, WEBSTER TJ, BANERJEE R. A nanoparticulate injectable hydrogel as a tissue engineering scaffold for multiple growth factor delivery for bone regeneration. Int J Nanomedicine. 2013;8:47-59.
[43] REY-RICO A, MADRY H, CUCCHIARINI M. Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair. Biomed Res Int. 2016; 2016:1215263.
[44] THORPE AA, FREEMAN C, FARTHING P, et al. In vivo safety and efficacy testing of a thermally triggered injectable hydrogel scaffold for bone regeneration and augmentation in a rat model. Oncotarget. 2018;9(26):18277-18295.
[45] TALAAT WM, HAIDER M, AL KAWAS S, et al. Chitosan-Based Thermosensitive Hydrogel for Controlled Drug Delivery to the Temporomandibular Joint. J Craniofac Surg. 2016;27(3):735-740.
[46] SCHWEIKLE M, ZINN T, LUND R, et al. Injectable synthetic hydrogel for bone regeneration: Physicochemical characterisation of a high and a low pH gelling system. Mater Sci Eng C Mater Biol Appl. 2018;90:67-76.
[47] BHATTARAI N, GUNN J, ZHANG M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev. 2010;62(1): 83-99.
[48] RUAN H, YU Y, GUO X, et al. The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation. Drug Des Devel Ther. 2018;12:1997-2003.
[49] LI X, LIU X, NI S, et al. Enhanced osteogenic healing process of rat tooth sockets using a novel simvastatin-loaded injectable microsphere-hydrogel system. J Craniomaxillofac Surg. 2019;47(7):1147-1154.
[50] RAHMAN S, GV G, MEHTA DS. A clinico-microbiological and biochemical study evaluating the adjunctive use of antimicrobial photodynamic therapy and local drug delivery of 1.2 % simvastatin gel compared to scaling and root planing alone. Photodiagnosis Photodyn Ther. 2020;32:102017.
|