中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (16): 2576-2583.doi: 10.12307/2022.260
• 生物材料综述 biomaterial review • 上一篇 下一篇
车振家,朱正清,朱礼伟,李友斌,祝晨一,黄岚峰
收稿日期:
2021-01-26
修回日期:
2021-01-28
接受日期:
2021-02-27
出版日期:
2022-06-08
发布日期:
2021-12-23
通讯作者:
黄岚峰,博士,硕士生导师,主任医师,教授,吉林大学第二医院骨科,吉林省长春市 130041
作者简介:
车振家,男,1996 年生,辽宁省营口市人,汉族,吉林大学第二医院在读硕士,主要从事骨组织工程细胞因子及骨与种植体整合的研究。
基金资助:
Che Zhenjia, Zhu Zhengqing, Zhu Liwei, Li Youbin, Zhu Chenyi, Huang Lanfeng
Received:
2021-01-26
Revised:
2021-01-28
Accepted:
2021-02-27
Online:
2022-06-08
Published:
2021-12-23
Contact:
Huang Lanfeng, MD, Master’s supervisor, Chief physician, Professor, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
About author:
Che Zhenjia, Master candidate, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Supported by:
摘要:
文题释义:
钛植入物骨整合:是指在人体活的骨组织与钛种植体之间发生的牢固、持久而直接的结合,即负载力量的种植体的表面与有活力的骨组织之间存在结构上和功能上直接的联系,种植体与骨组织之间没有任何结缔组织存在,不间隔任何组织。
生物化学改性:起初是作为化学改性的变异出现,是指通过将特定的蛋白、多肽、生长因子、多糖和核苷酸固定于种植体表面,这样可使生物活性分子直接在骨与植入体之间发挥作用,诱导成骨细胞增殖、分化和矿化,更为直接有效地促进骨整合。
背景:钛及钛合金因具有良好的机械性能和生物惰性等被广泛应用于骨科植入领域。
目的:综述不同的生物分子搭载到钛植入物表面对骨整合的影响。
方法:由第一作者应用计算机以“titanium,osseointegration,biochemical modification,coating”为英文检索词,以“钛,骨整合,生物化学改性,涂层”为中文检索词,应用计算机检索PubMed、Web of Science、维普、万方、中国知网数据库中1991-2020年已发表的相关文献,并进行筛选、归纳与总结,最终纳入104篇相关文献进行综述。
结果与结论:钛植入体表面单一的物理和化学修饰方式主要是间接影响细胞行为,而生物分子涂层可以直接参与生物过程,这在诱导骨形成方面更有效,不仅显著提高了骨与植入体之间早期的骨整合,还降低了因炎症反应导致的手术失败及假体翻修发生率。虽然钛植入物的生物化学改性可以直接参与生物过程,但是目前还有许多问题尚待解决:生物活性物质在钛植入体表面的长期稳定性、释放的速率以及钛植入物与机体细胞和组织之间的作用机制问题还需进一步研究,从而得到骨与钛植入物之间的早期和长期的骨整合。
https://orcid.org/0000-0001-9029-4097 (车振家)
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程
中图分类号:
车振家, 朱正清, 朱礼伟, 李友斌, 祝晨一, 黄岚峰. 钛植入物表面生物化学改性对骨整合的影响[J]. 中国组织工程研究, 2022, 26(16): 2576-2583.
Che Zhenjia, Zhu Zhengqing, Zhu Liwei, Li Youbin, Zhu Chenyi, Huang Lanfeng. Effects of biochemical modification of titanium implant surface on the osseointegration[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(16): 2576-2583.
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文题释义:#br# 钛植入物骨整合:是指在人体活的骨组织与钛种植体之间发生的牢固、持久而直接的结合,即负载力量的种植体的表面与有活力的骨组织之间存在结构上和功能上直接的联系,种植体与骨组织之间没有任何结缔组织存在,不间隔任何组织。#br# 生物化学改性:起初是作为化学改性的变异出现,是指通过将特定的蛋白、多肽、生长因子、多糖和核苷酸固定于种植体表面,这样可使生物活性分子直接在骨与植入体之间发挥作用,诱导成骨细胞增殖、分化和矿化,更为直接有效地促进骨整合。
该文系统综述了钛植入体表面分别搭载五种生物活性物质的生物化学改性对骨整合的影响,相较于单一的物理或化学改性,生物化学改性可以使钛植入物直接参与生物过程,所以首先介绍了各种生物活性分子搭载到钛植入物表面的方法,并通过体内外实验来证明经过修饰后的钛植入物对骨整合的影响;其次对各种生物化学改性的优势、不足以及可能的优化方法进行了归纳总结;最后对骨组织与植入体间牢固、持久而直接的结合进行了展望。
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程#br#
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