中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (35): 5577-5581.doi: 10.12307/2021.283

• 骨组织构建 bone tissue construction •    下一篇

基于内脏脂肪面积预测女性低骨量的风险切点

秦  迁1，杨  阳1，陈静锋1，王守俊2，丁素英1   

  1. 郑州大学第一附属医院，1健康管理中心， 2内分泌与代谢病科，河南省郑州市   450052
  • 收稿日期:2020-07-25 修回日期:2020-07-28 接受日期:2020-10-09 出版日期:2021-12-18 发布日期:2021-07-29
  • 通讯作者: 丁素英，硕士，主任护师，郑州大学第一附属医院，河南省郑州市 450052
  • 作者简介:秦迁，女，1989年生，河南省郑州市人，2016年郑州大学毕业，硕士，医师，主要从事骨质疏松方面的研究
  • 基金资助:
    河南省科技攻关计划项目(172102310049)，项目负责人：丁素英；河南省高等学校重点科研项目计划(21A320035)，项目负责人：丁素英；河南省医学科技攻关计划项目(LHGJ20200279)，项目负责人：陈静锋；河南省青年人才托举工程项目(2021HYTP052)，项目负责人：陈静锋

Cut-off point of visceral fat area: predicting low bone mass in women

Qin Qian1, Yang Yang1, Chen Jingfeng1, Wang Shoujun2, Ding Suying1   

  1. 1Health Management Center, 2Department of Endocrinology and Metabolic Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
  • Received:2020-07-25 Revised:2020-07-28 Accepted:2020-10-09 Online:2021-12-18 Published:2021-07-29
  • Contact: Ding Suying, Master, Chief nurse, Health Management Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
  • About author:Qin Qian, Master, Physician, Health Management Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
  • Supported by:
    Henan Provincial Science and Technology Research Plan, No. 172102310049 (to DSY); the Key Scientific Research Project of Colleges and Universities in Henan Province, No. 21A320035 (to DSY); Henan Province Medical Science and Technology Research Plan, No. LHGJ20200279 (to CJF); Henan Province Youth Talent Promotion Project, No. 2021HYTP052 (to CJF)

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摘要：

文题释义：

定量CT：即定量X射线计算机体层摄影技术，区别于传统CT的特点是体模的运用，校正CT值漂移，从而准确地测量出单位体积内的骨矿物质含量，弥补了CT值只能代表相对骨密度的缺点，同时联合肺CT测定，不增加辐射剂量。
生物电阻抗：文章采用生物电阻抗法测定人体体质成分，包含骨骼肌、脂肪、内脏脂肪面积等。
背景：近几年肥胖尤其是腹型肥胖与骨密度的关系备受关注，有研究认为内脏脂肪面积是骨密度降低的危险因素，也有一些研究认为年龄和内脏脂肪面积及骨密度之间的关系存在交互作用。
目的：探讨人体成分各指标与骨密度的相关性，并预测低骨量的内脏脂肪面积风险切点。
方法：回顾性分析在郑州大学第一附属医院健康管理中心进行定量CT和生物电阻抗测定的受检者的内脏脂肪面积及骨密度，采用Pearson相关、多因素线性回归与Logistic回归分析法分析人体成分各指标和骨密度及低骨量的相关性。绘制受试者工作特征曲线，确定预测低骨量的内脏脂肪面积切点值。
结果与结论：①随着年龄的增加，骨密度逐渐下降，内脏脂肪面积逐渐增加，基础代谢率逐渐下降；②多因素线性回归分析显示年龄、内脏脂肪面积与骨密度呈负相关；③多因素Logistic回归分析显示，绝经后女性内脏脂肪面积和低骨量相关；④受试者工作特征曲线预测绝经后女性低骨量的内脏脂肪面积切点值为117.85 cm2；⑤提示内脏脂肪面积是除了年龄外预测低骨量的危险因子，有望在今后骨矿物质健康管理中发挥重要作用，应对达到内脏脂肪面积风险切点的绝经后女性早期加强减脂管理，以减少低骨量的发病率及医疗和经济负担。
https://orcid.org/0000-0002-8464-0624 (秦迁)；0000-0002-2649-8332 (丁素英)

关键词: 低骨量, 女性, 骨密度, 内脏脂肪面积, 定量CT, 生物电阻抗

Abstract: BACKGROUND: In recent years, concerns have been paid to the relationship between obesity, especially abdominal obesity, and bone mineral density. Studies have concluded that visceral fat area is a risk factor for reducing bone mineral density. There are also some studies suggesting an interaction between age, visceral fat area and bone mineral density.
OBJECTIVE: To explore the correlation between body composition and bone mineral density, and to predict the risk cut-off point of visceral fat area for low bone mass.
METHODS: We retrospectively analyzed visceral fat area and bone mineral density measured by quantitative CT and bioelectrical impedance analysis in the Health Management Center, the First Affiliated Hospital of Zhengzhou University. Pearson correlation and multivariate linear regression analyses were used to analyze the correlation between body composition and bone mineral density, and multivariate Logistic regression analysis was used to analyze the correlation between body composition and low bone mass. Receiver characteristic operator curve was plotted to determine the cut-off point value of visceral fat area that predicts low bone mass.
RESULTS AND CONCLUSION: With the increase of age, bone mineral density gradually decreased, visceral fat area gradually increased, and basal metabolic rate gradually decreased. Multivariate linear regression analysis showed that age and visceral fat area were negatively correlated with bone mineral density. Multivariate Logistic regression analysis indicated that the visceral fat area of postmenopausal women was related to low bone mass. The cut-off point value of visceral fat area under receiver characteristic operator curve predicting low bone mass and osteoporosis in postmenopausal women was 117.85 cm2. In addition to age, visceral fat area is a risk factor for predicting osteoporosis. In order to reduce the incidence of osteoporosis and the medical and economic burden, we should strengthen the management of fat reduction in early-stage postmenopausal women. 

Key words: low bone mass, female, bone mineral density, visceral fat area, quantitative CT, bioelectrical impedance analysis

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