A systematic review and meta-analysis of the effects of long-term exercise on blood lipids in healthy elderly people

doi:10.12307/2023.156

Abstract

Abstract: OBJECTIVE: To evaluate the effect of long-term exercise on the blood lipids of healthy elderly people and to explore whether long-term exercise can affect the low-density lipoprotein of older adults.
METHODS: A literature search was performed in PubMed, Cochrane library, EBSCO, and CNKI databases to collect randomized controlled trials on the effects of long-term exercise on blood lipids of healthy elderly people. Cochrane’s risk assessment tool was used to evaluate the methodological quality of the included literature. Stata14.0 software was used to analyze the heterogeneity and potential publication bias of the included literature.
RESULTS: A total of 9 articles were included, including 409 participants (226 in the experimental group and 183 in the control group). (1) Meta-analysis results showed that compared with the control group, long-term exercise could reduce triglyceride [standardized mean difference (SMD)=-0.67, 95% confidence interval (CI): -1.14 to -0.20, P=0.006) and total cholesterol (SMD=-0.42, 95% CI: -0.82 to -0.02, P=0.04), and increase high-density lipoprotein (SMD=0.71, 95% CI: 0.08-1.33, P=0.026) in older adults, but there was no significant change in low-density lipoprotein level after exercise intervention (SMD=-0.17, 95% CI: -0.36 to 0.02, P=0.085). Subgroup analysis results revealed that ≥ 150 minutes of exercise per week could effectively improve blood lipids and the total effect size was greater than that of < 150 minutes of exercise per week.
CONCLUSION: Long-term exercise can effectively improve the levels of triglyceride, total cholesterol, and high-density lipoprotein in healthy elderly people, but the effect on improving low density lipoprotein has not been determined, which may be related to a variety of factors. We suggest that when exercising to improve blood lipids, we should not only pay attention to the effect on total low-density lipoprotein, but also focus on the health benefits of exercise for adults or older adults with different health conditions. At the same time, in order to better improve the health effects of exercise, we recommend that older adults need at least 150 minutes of exercise a week. However, due to the obvious heterogeneity of the included studies, the conclusions of this study need to be verified by more high-quality studies.

Key words: older adults, exercise, blood lipid, low-density lipoprotein, randomized controlled trial, Meta-analysis

CLC Number:

Peng Tuanhui, Yang Ling, Ding Xiaoge, Meng Pengjun. A systematic review and meta-analysis of the effects of long-term exercise on blood lipids in healthy elderly people[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(14): 2276-2282.

Figures/Tables 12

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