中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (24): 3906-3911.doi: 10.3969/j.issn.2095-4344.2014.24.022

• 组织构建综述 tissue construction review • 上一篇    下一篇

细胞因子与针灸治疗膝骨关节炎：实验与应用

张永亮1，2，宓轶群1，2，刚嘉鸿1，王文辉3   

  1. 1上海交通大学附属第六人民医院针推伤科，上海市  200233
    2上海中医药大学研究生院，上海市  201203
    3上海市医疗质量控制管理事务中心，上海市  200040
  • 修回日期:2014-05-26 出版日期:2014-06-11 发布日期:2014-06-11
  • 通讯作者: 宓轶群，主任医师，硕士生导师，上海交通大学附属第六人民医院针推伤科，上海市 200233；上海中医药大学研究生院，上海市 201203
  • 作者简介:张永亮, 男, 1988年生， 河北省秦皇岛市人，汉族，上海中医药大学在读硕士。
  • 基金资助:

    课题由上海市卫生局中医药科研基金资助(2012J012A)

Cytokines and acupuncture in the treatment of knee osteoarthritis: experiments and applications

Zhang Yong-liang1, 2, Mi Yi-qun1, 2, Gang Jia-hong1, Wang Wen-hui3   

  1. 1Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
    2Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3Shanghai Medical Quality Control and Management Center, Shanghai 200040, China
  • Revised:2014-05-26 Online:2014-06-11 Published:2014-06-11
  • Contact: Mi Yi-qun, Chief physician, Master’s supervisor, Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China; Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • About author:Zhang Yong-liang, Studying for master’s degree, Department of Acupuncture & Moxibustion Tuina Traumatology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China; Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Supported by:

    Scientific Research Funds of Traditional Chinese Medicine of Shanghai Municipal Health Bureau, No. 2012J012A

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摘要：

背景：研究表明针灸治疗膝骨关节炎具有一定的效果。
目的：详细阐述针灸治疗膝骨关节炎的细胞因子实验研究进展。
方法：查阅PubMed、WOK、CNKI、维普、万方等相关数据库，查找关于针灸治疗膝骨关节炎实验研究的文献，对资料进行初审，剔除无关文献，保留与膝骨关节炎相关细胞因子研究文献，排除重复研究及不典型报道。
结果与结论：共纳入48篇符合标准文献，包括中文文献31篇，英文文献17篇。经分析得出：与膝关节骨性关节炎相关的细胞因子大体上分为损伤性细胞因子和保护性细胞因子。损伤性细胞因子有基质金属蛋白酶、白细胞介素、肿瘤坏死因子α、前列腺素E2、一氧化氮、软骨寡聚基质蛋白等，保护性细胞因子有骨形态发生蛋白、转化生长因子β、骨保护素、胰岛素样生长因子1、碱性成纤维细胞生长因子等。大量实验研究表明针灸可以降低损伤性细胞因子如基质金属蛋白酶1、基质金属蛋白酶3、白细胞介素1β、白细胞介素6、肿瘤坏死因子α、前列腺素E2、软骨寡聚基质蛋白、一氧化氮的含量、调节基质金属蛋白酶1/组织金属蛋白酶抑制剂1的比值失衡，提高保护性细胞因子如骨形态发生蛋白、转化生长因子β、骨保护素、胰岛素样生长因子1、碱性成纤维细胞生长因子的含量。从而起到抗炎，防止关节软骨退变，促进软骨组织修复的作用。



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 骨组织工程, 针灸疗法, 骨关节炎, 膝, 细胞因子, 关节炎实验, 综述

Abstract:

BACKGROUND: Studies have shown that acupuncture treatment have some effects in knee osteoarthritis.
OBJECTIVE: To review the cytokines studies of acupuncture treatment on knee osteoarthritis.
METHODS: A computer-based retrieval of PubMed, WOK, CNKI, VIP, Wanfang databases was performed to find the literatures on acupuncture treatment of knee osteoarthritis. All data were primarily screened to exclude irrelevant literature. Those literatures about the cytokines related to knee osteoarthritis were included. Repetitive studies and untypical study reports were excluded.
RESULT AND CONCLUSION: Totally 48 articles were collected, including 31 in Chinese and 17 in English. The analysis results showed that, the cytokines associated with knee osteoarthritis can be substantially divided into destructive cytokines and protective cytokines. Destructive cytokines include matrix metalloproteinase, interleukin, tumor necrosis factor-α, prostaglandin E2, nitrogen monoxidum, and cartilage oligomeric matrix protein. Protective cytokines include bone morphogenetic protein, transforming growth factor-β, osteoprotegerin, insulin-like growth factor-1, and basic fibroblast growth factor. Many experimental studies have shown that acupuncture can reduce the levels of destructive cytokines such as matrix metalloproteinase, interleukin, tumor necrosis factor-α, prostaglandin E2, nitrogen monoxidum, and cartilage oligomeric matrix protein, and adjust the matrix metalloproteinase 1/tissue inhibitor of metalloproteinase 1 ratio imbalances, improve the levels of protective cytokines such as bone morphogenetic protein, transforming growth factor-β, osteoprotegerin, insulin-like growth factor-1, and basic fibroblast growth factor. Therefore acupuncture plays the role of anti-inflammatory, preventing the degeneration of articular cartilage, and promoting cartilage tissue repair.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: acupuncture, osteoarthritis, knee, cytokines

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