中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (7): 1115-1120.doi: 10.3969/j.issn.2095-4344.2014.07.022

• 组织构建综述 tissue construction review • 上一篇    下一篇

组织工程化牙齿再生：热点与应用

刘鹏鹏1，沈慧娟2，王子轶3，吴银芳1，金光勇1，祁倩娴1，曾宪智4   

  1. 1嘉兴学院医学院，浙江省嘉兴市  314001
    2嘉兴学院机电学院机电工程中心，浙江省嘉兴市  314001
    3浙江省武警总队医院口腔科，浙江省嘉兴市  314000
    4嘉兴学院医学院解剖学教研室，浙江省嘉兴市  314001
  • 修回日期:2013-12-04 出版日期:2014-02-12 发布日期:2014-02-12
  • 通讯作者: 通讯作者：曾宪智，博士，副教授，嘉兴学院医学院解剖学教研室， 浙江省嘉兴市 314001
  • 作者简介:刘鹏鹏，男，1991年生， 浙江省丽水市人，汉族，嘉兴学院医学院本科在读，主要从事临床医学方面的研究。
  • 基金资助:

    浙江省自然科学基金项目(Y2110158)；嘉兴市科技计划项目(2011AY1053-1)；嘉兴市科技计划项目(2012AY1075-11)；浙江省大学生科技创新活动计划项目(2012R417006)；嘉兴学院重点SRT计划项目(851712004)

Tissue-engineered tooth regeneration: hotspots and clinical application

Liu Peng-peng1, Shen Hui-juan2, Wang Zi-yi3, Wu Yin-fang1, Jin Guang-yong1, Qi Qian-xian1,  Zeng Xian-zhi4   

  1. 1School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China
    2Electrical Engineering Center, School of Mechanical Engineering, Jiaxing University, Jiaxing 314001, Zhejiang Province, China
    3Department of Stomatology, Zhejiang Provincial People’s Armed Police Corps Hospital, Jiaxing 314000, Zhejiang Province, China
    4Department of Anatomy, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China
  • Revised:2013-12-04 Online:2014-02-12 Published:2014-02-12
  • Contact: Zeng Xian-zhi, M.D., Associate professor, Department of Anatomy, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China
  • About author:Liu Peng-peng, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China
  • Supported by:

    the Natural Science Foundation of Zhejiang Province, No. Y2110158; the Science and Technology Program of Jiaxing City, No. 2011AY1053-1, 2012AY1075-11; the Science and Technology Innovation Program of Undergraduate of Zhejiang Province, No. 2012R417006; Key Program of Student Research Training of Jiaxing University, No. 851712004

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摘要：

背景：临床有一些方法治疗牙齿缺失比如假牙和牙齿种植，被认为有安全和使用寿命的问题。鉴于生物学和生物材料科学的发展，最近牙齿组织工程引起越来越多的关注。
目的：综述用组织工程方法促进牙齿再生的热点与问题。
方法：以“tissue engineering, tooth regeneration”为检索词，应用计算机检索 Pubmed数据库(2007至2013年)；以“组织工程、牙齿再生”为检索词，检索中国期刊网全文数据库(2007至2013年)；共收集 65篇关于组织工程牙齿再生方面的文献，中文25篇，英文40篇，排除发表时间较早、重复及类似研究，纳入48篇符合标准的文献。
结果与结论：干细胞与合适的组织工程支架被广泛地应用在牙齿再生中，其中相当一部分研究还加入能够产生促进牙齿再生的生长因子或骨髓液，实现了部分或全部的牙齿再生。但对于牙齿再生的机制研究显然不足。



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 组织工程, 牙齿再生, 生物材料, 干细胞, 浙江省自然科学基金

Abstract:

BACKGROUND: Although several prosthetic methods, such as artificial denture and dental implants, are clinical therapies to tooth loss, they are thought to have safety and usage time issues. With the development of biological and biomaterial sciences, recently, tooth tissue engineering has attracted more and more attention.
OBJECTIVE: To reflect advances and problems of tissue engineering technologies for promotion of tooth regeneration.
METHODS: Using the keywords of “tissue engineering, tooth regeneration” in English and Chinese, PubMed and CNKI databases from 2007 to 2013 were retrieved. A total of 65 literatures addressing tooth regeneration and 
tissue engineering were collected, including 25 Chinese articles and 40 English articles. Published early, repetitive, and similar researches were excluded. Finally, 48 articles were included.
RESULTS AND CONCLUSION: The combination of stem cells and suitable scaffolds is widely used in tooth regeneration today, and growth factors or bone marrow which can produce promote tooth regeneration are added as well, which has achieved partial or whole tooth regeneration. But there are apparent deficiencies in studies which focus on mechanisms behind tooth regeneration.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: tissue engineering, tooth loss, regeneration, stem cells

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