中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (51): 9643-9647.doi: 10.3969/j.issn.1673-8225.2011.51.034

• 生物材料综述 biomaterial review • 上一篇    下一篇

壳聚糖在肿瘤放射治疗中的作用及应用

刘  斌1,2，张宝平2，张  红1，李志革2，潘晓婧2   

  1. 1中国科学院近代物理研究所，甘肃省兰州市   730000
    2兰州大学口腔医学院，甘肃省兰州市   730000
  • 收稿日期:2011-06-04 修回日期:2011-07-18 出版日期:2011-12-17 发布日期:2011-12-17
  • 通讯作者: 张红，博士，研究员，博士生导师，中国科学院近代物理研究所及中国科学院重离子束辐射生物医学重点实验室，甘肃省兰州市 730000 zhangh@ impcas.ac.cn
  • 作者简介:刘斌☆，男，甘肃省民勤县人，汉族，2006年中国科学院化学物理研究所毕业，博士，教授，硕士生导师，主要从事医用材料及物理粒子的应用研究。 liubkq@ lzu.edu.cn
  • 基金资助:

    国家重点基础研究发展计划资助项目(2010CB834202)；国家自然科学基金重点项目(10835011)；甘肃省2007年重大科技专项项目(O702NKDA045)；甘肃省2008 年重大科技专项项目(0801NKDA001)；兰州大学中央高校基本科研费2011年项目(lzujbky-2011-134)。

Application and role of chitosan in tumor radiotherapy

Liu Bin1, 2, Zhang Bao-ping2, Zhang Hong1, Li Zhi-ge2, Pan Xiao-jing2   

  1. 1Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou  730000, Gansu Province, China
    2College of Stomatology, Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Received:2011-06-04 Revised:2011-07-18 Online:2011-12-17 Published:2011-12-17
  • Contact: Zhang Hong, Doctor, Researcher, Doctoral supervisor, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China zhangh@ impcas.ac.cn
  • About author:Liu Bin☆, Doctor, Professor, Master’s supervisor, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China; College of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • Supported by:

    State Key Development Program of Basic Research of China, No. 2010CB834202*; Major Program of National Natural Science Foundation of China, No. 10835011*; Major Project of Science and Technology of Gansu Province in 2007, No. O702NKDA045*; Major Project of Science and Technology of Gansu Province in 2008, No. 0801NKDA001*; Basic Research Fee for Central Universities, Lanzhou University in 2011, No. lzujbky-2011-134*

PDF

379

摘要：

背景：通过增敏剂来提高放射治疗效果是目前肿瘤放疗领域的研究热点之一。壳聚糖具有良好的生物相容性和生物降解性，也可作为一种多功能的放疗增敏剂，运用于放射治疗的协同治疗。
目的：对近年国内外关于壳聚糖在肿瘤放疗中的研究现状、应用原则以及发展趋势进行综述。
方法：计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据库(IPSEN)、中国生物医学文献数据库(CBM)、Elsevier数据库和Pubmed数据库，收集到1995/2008发表有关壳聚糖生物作用研究的中英文文献194篇。阅读标题和摘要进行初筛，共保留其中的48篇归纳总结，从壳聚糖的自身抗肿瘤效应、对放射治疗的增敏作用以及对正常组织保护作用三方面分析，以进行壳聚糖对放疗增敏性的研究总结。
结果与结论：从壳聚糖抗肿瘤效应、对放射治疗的增敏作用以及对正常组织保护作用的实验中，证实了壳聚糖可作为一种多功能的放疗增敏剂。

关键词: 壳聚糖, 肿瘤, 放射治疗, 增敏, 保护作用

Abstract:

BACKGROUND: Currently, the improvement in the effect of radiation therapy by sensitizer is one of the hotspot in tumor radiotherapy field. Chitosan has a good biocompatibility and biodegradability, and can be used as a kind of multi-functional sensitizer to apply in radiotherapy for synergy therapy.
OBJECTIVE: To summarize the research status, application principle and development of chitosan applied in tumor radiotherapy at home and abroad recently.
METHODS: A computer-based online search of literatures related to biological effect of chitosan published between 1995 and 2009 in CNKI database, VIP database, Wanfang database, China Biology Medicine disc, Elsevier database and PubMed database was performed. Totally 194 articles in Chinese and in English were collected. 48 of them were chosen to summarize according to inclusion criteria. The anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan were analyzed to summarize its radiosensitivity.
RESULTS AND CONCLUSION: Chitosan has been proved to be a kind of multi-functional sensitizer for radiotherapy by the experiments of the anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan.

中图分类号: