中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (7): 1299-1302.doi: 10.3969/j.issn.1673-8225.2010.07.037

• 组织构建综述 tissue construction review • 上一篇    下一篇

胰岛素样生长因子与运动性心肌肥大

吴  薇1，李  欣1, 2   

  1. 1绵阳师范学院体育与健康教育学院，四川省绵阳市  621000；2华东师范大学体育与健康学院，上海市，200241
  • 出版日期:2010-02-12 发布日期:2010-02-12
  • 作者简介:吴 薇★，女，1981年生，四川省德阳市人，汉族，2005年上海体育学院运动科学系毕业，硕士，讲师，主要从事运动与健康促进方面的研究。 wei_wu1981@yahoo.com.cn

Effect of insulin-like growth factor on exercise-induced cardiac hypertrophy

Wu Wei1, Li Xin 1, 2   

  1. 1 School of Sports and Health Education, Mianyang Normal University, Mianyang   621000, Sichuan Province, China; 2 School of Sports and Health Care, East China Normal University, Shanghai   200241, China
  • Online:2010-02-12 Published:2010-02-12
  • About author:Wu Wei★, Master, Lecturer, School of Sports and Health Education, Mianyang Normal University, Mianyang 621000, Sichuan Province, China wei_wu1981@yahoo.com.cn

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500

被引次数

3

摘要：

背景：胰岛素样生长因子1对心脏具有重要的生物学效应，可以促进心肌和血管平滑肌的生长和代谢。
目的：综述胰岛素样生长因子1的生物学效应，以期明确其对运动性心肌肥大的发生机制。更好地利用运动对IGF1的影响来实现心脏适应性肥大。
方法：以“exercise-induced cardiac hypertrophy, insulin-like growth factor, exercise”为检索词，检索Pubmed数据库(1990-01/2009-04)；以运动性心肌肥大，胰岛素样生长因子，运动为检索词，检索CNKI数据库(1990-01/2009-04)。文献检索语种限制为英文和中文。纳入与胰岛素样生长因子联系紧密的动物实验研究和临床应用研究；排除内容陈旧的文献和Meta分析。
结果与结论：计算机初检得到41篇文献，根据纳入排除标准，对其中31篇文献进行分析。胰岛素样生长因子与其他生长因子一起协同促进多种细胞的分化成熟。现有资料表明血清及心脏局部胰岛素样生长因子 1对心肌肥大的发生具有重要作用。文章采用文献资料法，分析了循环和心肌胰岛素样生长因子的产生和作用机制，探讨了心脏局部胰岛素样生长因子的功能以及运动对其的影响；得出了运动能改变循环和心肌胰岛素样生长因子的表达以及心脏局部胰岛素样生长因子与运动性心肌肥大的形成有关。

关键词: 运动性心肌肥大, 胰岛素样生长因子, 运动, 机制, 综述文献

Abstract:

BACKGROUND: Insulin-like growth factor-1 (IGF-1) has important biological effects on the heart, it can promote cardiac and vascular smooth muscle growth and metabolism.
OBJECTIVE: To summarize the biological effects of IGF-1, to clarify the mechanism of exercise-induced cardiac hypertrophy, and make better use of the exercise influence on IGF1 to achieve adaptive cardiac hypertrophy.
METHODS: With exercise-induced cardiac hypertrophy, insulin-like growth factor, exercise in English for the search terms, Pubmed database from January 1990 to April 2009 was retrieved; With exercise-induced cardiac hypertrophy, insulin-like growth factor, exercise in Chinese for the search terms, CNKI database from January 1990 to April 2009 was searched. Literatures were limited to English and Chinese languages. Inclusive criteria: animal experimental study and clinical application research closely linked to IGF-1; exclusive criteria: the old literatures and Meta analysis.
RESULTS AND CONCLUSION: Totally 41 literatures were screened out by computers, according to the inclusion and exclusion criteria, 31 documents of which were involved for analysis. The IGF coordinates with other growth factors to promote differentiations and maturity of a variety of cells. The current data indicate that the blood serum and the cardiac local IGF-1 play an important role on cardiac hypertrophy. This study used the method of literature to analyze the production and action mechanism of the circulatory and cardiac IGF, discuss the functions of cardiac local IGF and the effect of exercise on it, and bring forward that exercise can alter the IGF expressions, IGF is related to the formation of exercise-induced cardiac hypertrophy. 

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