中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (47): 8873-8876.doi: 10.3969/j.issn.1673-8225.2010.47.033

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程支架材料修复运动性软骨损伤

王永胜   

  1. 河南理工大学体育学院人体科学实验室，河南省焦作市 454000　
  • 出版日期:2010-11-19 发布日期:2010-11-19
  • 作者简介:王永胜★，男，汉族，1977年生，河南省漯河市人，硕士，主要从事运动训练与体育保健学的研究。 sqh@hpu.edu.cn

Tissue engineering scaffold materials repair sports cartilage injury

Wang Yong-sheng   

  1. Human Body Science Laboratory, College of Physical Education, Henan Polytechnic University, Jiaozuo   454000, Henan Province, China
  • Online:2010-11-19 Published:2010-11-19
  • About author:Wang Yong-sheng★, Master, Human Body Science Laboratory, College of Physical Education, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China sqh@hpu.edu.cn

PDF

522

被引次数

4

摘要：

目的：对运动性软骨损伤因素和特点进行探讨，并对其修复过程中人工生物材料干预下支架材料的选择与应用情况进行分类和归纳。
方法：作者应用计算机检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI数据库(www.cnki.net/index.htm)，在标题和摘要中以“软骨，损伤，生物材料，支架，治疗”或“cartilage, damage, biological materials, support，treatment”为检索词进行检索。选择文章内容与软骨支架材料治疗手段、材料学特点、生物相容性及其应用效果相关，同一领域文献则选择近期发表或发表在权威杂志文章，共纳入26篇文献。
结果：近半个世纪以来，软骨组织工程支架材料的选择与研制经历了天然材料、合成材料等由单一材料向复合材料研制快速发展的时期，另外，基因技术、纳米材料和改性修饰材料技术的运用，为软骨组织损伤后的愈合与康复提供了更大可能与保障。
结论：软骨损伤多由于突发暴力所致，由于软骨损伤后自身没有修复功能，故软骨损伤后使用传统疗法较难治愈。随着组织工程学的兴起，组织工程技术逐步运用于软骨康复技术，并取得了巨大的成功，在诸多环节中，其中软骨支架材料的选择与研制尤为重要。单一天然材料和合成材料存在诸多缺点，所以研制复合材料、仿生材料、改性修饰材料，是今后支架材料研究的主要方向。随着组织工程学和生物工程技术以及纳米技术的快速发展和融合，多种材料与技术并用的新兴复合技术将进一步满足医患双方的需求。

关键词: 软骨, 损伤, 生物材料, 支架, 治疗　

Abstract:

OBJECTIVE: To investigate the factors and characteristics of sports cartilage injury, to classify and summarize the selection and application of artificial biomaterial scaffolds in the repair process.
METHODS: An online search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/ index.htm) was performed by screening the titles and abstracts with the key words of “Cartilage, Damage, Biological Materials, Support, Treatment” in English and in Chinese. Articles related to the treatment, materials science characteristics, biocompatibility and application effect of cartilage scaffolds were selected, these recently published or published in the authority journals were preferred in the same field, finally 26 articles were included in the analysis.
RESULTS: Over half a century, the selection and design of cartilage tissue engineering scaffold materials have developed from natural materials, synthetic materials, and other single materials to composite materials. In addition, gene technology, nano-materials and modified technology may provide greater potential and ensure for the healing and rehabilitation of cartilage injury.
CONCLUSION: The majority of cartilage injury is caused by sudden violence, and the cartilage cannot repair itself after injury, so cartilage injury is difficult to cure using conventional therapies. With the emergence of tissue engineering, tissue engineering technologies have been gradually applied to cartilage rehabilitation and achieved great success, in particularly the selection and development of cartilage scaffold materials. Single natural materials and synthetic materials have many disadvantages, so the major future direction of scaffold materials research is compound materials, biomimetic materials, and modified materials. With the rapid development and integration of tissue engineering, biological engineering technology and nanotechnology, new composite technology using a variety of materials and technologies will further meet the needs of both doctors and patients.

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