中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (33): 5385-5393.doi: 10.12307/2023.687
• 干细胞综述 stem cell review • 上一篇 下一篇
徐溶蔚,王 浩,付秋月,兰兴明,杨 琨
收稿日期:
2022-09-24
接受日期:
2022-10-12
出版日期:
2023-11-28
发布日期:
2023-03-30
通讯作者:
杨琨,博士,副教授,遵义医科大学附属口腔医院牙周科,贵州省遵义市 563000
作者简介:
徐溶蔚,女,2001年生,江苏省盐城市人,汉族。
王浩,男,2000年生,贵州省遵义市人,苗族。
基金资助:
Xu Rongwei, Wang Hao, Fu Qiuyue, Lan Xingming, Yang Kun
Received:
2022-09-24
Accepted:
2022-10-12
Online:
2023-11-28
Published:
2023-03-30
Contact:
Yang Kun, MD, Associate professor, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
About author:
Xu Rongwei, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Wang Hao, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Supported by:
摘要:
文题释义:
牙髓干细胞:是从牙髓组织分离的,来自神经嵴的外胚间充质干细胞,具有自我更新、免疫调节、多向分化潜能和易获得等特点,一定条件下可分化为神经样细胞、成牙本质细胞和成骨细胞等,目前已被报道在神经、口腔和骨骼等部位的再生医学价值,有良好的临床应用前景。结果与结论:①牙髓干细胞作为牙源性间充质干细胞,有着众人熟知的多向分化特性,其中成骨分化潜能是骨组织工程的研究热点。②炎症因素不论是作为细胞所处的微环境、可调节的免疫炎症反应、抑或是需要再生修复的炎症性骨组织缺损疾病,都与牙髓干细胞介导的骨再生有着密切的关联,近年来也不乏相关的研究。③文章选取了近十年以来相关的文献报道,发现即使是发炎牙髓组织来源的炎症牙髓干细胞仍然保留一定的成骨分化潜能,而进一步分析骨再生过程中炎症因素与牙髓干细胞的双向关系,发现炎症因素对于牙髓干细胞成骨分化的影响和牙髓干细胞对于炎症的免疫调节都具有促进和抑制的双重作用,这主要与炎症递质的种类、浓度及作用时间等有关,但是具体机制都尚不全面。④近来学者的研究热点主要集中于探索介导炎症环境下牙髓干细胞成骨分化的促进因素,尤其是除了炎症递质以外的外源性因素如药物等。⑤也有一些动物实验和少数临床试验利用牙髓干细胞抗炎促成骨的特性验证了牙髓干细胞对炎症性骨缺损疾病尤其是对牙周炎和关节炎的治疗作用。⑥目前,骨再生过程中炎症因素与牙髓干细胞成骨分化双向作用的相关机制部分的研究还有较大的空缺,未来仍需进一步研究验证。
https://orcid.org/0000-0001-8820-0426 (徐溶蔚);https://orcid.org/0000-0003-1673-3463 (王浩);
https://orcid.org/0000-0002-7720-8681 (杨琨)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
徐溶蔚, 王 浩, 付秋月, 兰兴明, 杨 琨. 骨再生过程中炎症因素与牙髓干细胞的双向作用[J]. 中国组织工程研究, 2023, 27(33): 5385-5393.
Xu Rongwei, Wang Hao, Fu Qiuyue, Lan Xingming, Yang Kun. Bidirectional interaction between inflammatory factors and dental pulp stem cells during bone regeneration[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(33): 5385-5393.
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1.1.7 检索策略 具体检索策略见图1。
1.1.8 检索文献量 首次检索出文献919篇,包括中文文献251篇和英文文献668篇。
1.3 文献质量评估与数据的提取 初步检索出文献919篇,阅读摘要和全文后,剔除不符合纳入标准的文献,排除与研究目的相关性差及内容重复、资料陈旧的文献,最终纳入70篇英文文献和6篇中文文献,共计76篇进行综述,见图2。
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文题释义:
牙髓干细胞:是从牙髓组织分离的,来自神经嵴的外胚间充质干细胞,具有自我更新、免疫调节、多向分化潜能和易获得等特点,一定条件下可分化为神经样细胞、成牙本质细胞和成骨细胞等,目前已被报道在神经、口腔和骨骼等部位的再生医学价值,有良好的临床应用前景。中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
文章紧抓“炎症”“牙髓干细胞”和“骨再生”这3个要素,以骨再生过程中,炎症因素和牙髓干细胞的双向作用为主线展开分析。不同于现有的综述只阐述炎症与干细胞的相互作用或单纯分析牙髓干细胞的成骨分化潜能,文章关注牙髓干细胞免疫调节和成骨分化两个潜能,对极具应用前景的炎症牙髓干细胞也作了相关介绍,侧重于探讨炎症因素对牙髓干细胞成骨分化的双重影响以及牙髓干细胞联合抗炎和成骨两项特性对于炎症性骨缺损疾病的治疗作用,于骨组织工程和日后的临床研究都具有一定导向意义。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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