中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (31): 5833-5836.doi: 10.3969/j.issn. 2095-4344.2012.31. 028

• 器官移植基础实验 basic experiments of organ transplantation • 上一篇    下一篇

高尔基糖蛋白73在各种良性终末期肝病肝组织中的表达

单 姗，陈 虹，王乐天   

  1. 单姗★，女，1981年生，黑龙江省双鸭山市人，汉族，2010年贵阳医学院毕业，硕士，医师，主要从事肝移植内科、移植随访工作。
    33shanshan007@163.com
  • 收稿日期:2012-01-17 修回日期:2012-05-12 出版日期:2012-07-29 发布日期:2012-07-29
  • 通讯作者: 陈虹，博士，主任医师，硕士生导师，武装警察部队总医院移植科，北京市 100039 ch61520@163. com
  • 作者简介:单姗★，女，1981年生，黑龙江省双鸭山市人，汉族，2010年贵阳医学院毕业，硕士，医师，主要从事肝移植内科、移植随访工作。 33shanshan007@163.com

Expression of Golgi protein-73 in the liver tissue of patients with benign end-stage liver diseases

Shan Shan, Chen Hong, Wang Le-tian   

  1. Department of Transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
  • Received:2012-01-17 Revised:2012-05-12 Online:2012-07-29 Published:2012-07-29
  • Contact: Chen Hong, Doctor, Chief physician, Master’s supervisor, Department of Transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China ch61520@163.com
  • About author:Shan Shan★, Master, Physician, Department of Transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China 33shanshan007@ 163.com

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摘要：

背景：高尔基糖蛋白73是随着蛋白质组学技术发展而新近发现的糖蛋白，与各种急慢性肝炎及肝癌关系密切。
目的：观察高尔基糖蛋白73在各种终末期良性肝病行肝移植的病肝组织和正常肝脏组织中的表达及其意义，并分析与预后的关系。
方法：采用免疫组织化学染色SP法检测113例因各种终末期良性肝病行肝移植的石蜡标本及10例供肝正常肝脏组织中高尔基糖蛋白73的表达。
结果与结论：高尔基糖蛋白73在因各种终末期良性肝病行肝移植的病肝组织中均有表达且表达水平高于正常肝脏组织。高尔基糖蛋白73在自身免疫性肝炎所致肝硬化中的表达水平高于其在乙肝肝硬化中的表达水平，高尔基糖蛋白73在其他各组病肝组织中表达均无差异。提示高尔基糖蛋白73在自身免疫性肝炎依赖的非病毒途径中的表达可能高于其在HBV病毒途径中的表达。

关键词: 高尔基糖蛋白73, 肝移植, 良性终末期肝病, 免疫组织化学

Abstract:

BACKGROUND: Golgi protein-73 is a glycoprotein which discovered with the proteomics technology development. It has close relation with acute and chronic hepatitis and hepatocellular cancer.
OBJECTIVE: To investigate the expression of Golgi protein-73 in liver tissue of the patients with benign end-stage liver diseases and normal liver tissue, and to analyze their clinical significance and prognostic value.
METHODS: 113 specimens of liver transplantation for patients with benign end-stage liver disease and 10 normal liver specimens were included in the study. The expressions of Golgi protein-73 in these specimens were detected by immunohistochemistry.
RESULTS AND CONCLUSION: Golgi protein-73 expression levels in specimens of liver transplantation for patients with benign end-stage liver diseases were higher than those in normal liver specimens without liver disease. Golgi protein-73 expression levels in specimens of autoimmune hepatitis cirrhosis were higher than those in hepatitis B cirrhosis. There was no significant difference of Golgi protein-73 expression among all other groups. Golgi glycoprotein 73 expression in autoimmune hepatitis depended non-viral pathway was higher than that in HBV viral way.

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