中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (20): 3229-3234.doi: 10.3969/j.issn.2095-4344.1238

• 骨与关节综述 bone and joint review • 上一篇    下一篇

富血小板血浆在跟腱损伤修复中的应用

赵茂胜1,2,封国超1,2,邓银栓2,甄 平2   

  1. 1甘肃中医药大学,甘肃省兰州市  7300002解放军兰州军区兰州总医院,甘肃省兰州市 730050
  • 出版日期:2019-07-18 发布日期:2019-07-18
  • 通讯作者: 甄平,主任医师,教授,解放军兰州军区兰州总医院,甘肃省兰州市 730050
  • 作者简介:赵茂胜,男,1991年生,汉族,甘肃中医药大学在读硕士。
  • 基金资助:

    国家自然科学基金(81371983),项目负责人:甄平|军队科研计划面上项目(CWH17J007),项目负责人:邓银栓

Application of platelet-rich plasma in repair of Achilles tendon injury

Zhao Maosheng1, 2, Feng Guochao1, 2, Deng Yinshuan2, Zhen Ping2   

  1. 1Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; 2Lanzhou General Hospital of Lanzhou Military Region of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • Online:2019-07-18 Published:2019-07-18
  • Contact: Zhen Ping, Chief physician, Professor, Lanzhou General Hospital of Lanzhou Military Region of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • About author:Zhao Maosheng, Master candidate, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; Lanzhou General Hospital of Lanzhou Military Region of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81371983 (to ZP)| the Military Science Research Program, No. CWH17J007 (to DYS)

摘要:

文章快速阅读:

 

 

文题释义:
富血小板血浆(PRP):是指采集患者外周静脉血经离心后获得浓缩血小板的血液制品,其中含有的血小板量为正常全血的3-6倍,并含有大量的生长因子,现广泛应用于组织再生、创面修复、感染治疗和功能重建等领域。
跟腱炎:是由于肌腱长期反复承受过度负荷和过度使用等过程中产生的慢性无菌性炎症,病理改变包括充血、水肿、变性甚至钙化等,是骨科、运动医学科的常见病,是足后部疼痛的常见原因之一。
 
摘要
背景:富血小板血浆疗法为跟腱损伤的愈合与修复提供了新的方向,其应用已成为近年来国内外研究的热点,表现出了良好的应用前景。
目的:对近些年来国内外富血小板血浆疗法的作用机制以及治疗跟腱病的应用现状及研究进展进行综述。
方法:通过计算机检索中国期刊全文数据库(CNKI)、万方数据库和PubMed数据库2009年1月至2018年9月的相关文章,以“富血小板血浆、肌腱病、跟腱炎、跟腱断裂、生长因子”,英文检索词为“platelet-rich plasma (PRP),tendinopathy,Achilles tendinitis,Achilles tendon rupture,growth factor”,选取与富血小板血浆疗法、跟腱病的愈合与修复相关的文章,并进行总结、整理与分析。
结果与结论:文章对已纳入的45篇文献进行分析,结果表明生长因子的浓度是治疗跟腱损伤的关键,虽然与传统的保守治疗和单纯的手术治疗相比,富血小板血浆疗法在对跟腱病治疗的影像学表现、功能相关评分以及生活质量上均表现出了良好的优势,但是富血小板血浆疗法在跟腱损伤上的应用从制备、浓度、注射方式均无统一标准,目前富血小板血浆疗法仍缺乏明确严谨的临床指南作为依据。

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程
ORCID: 0000-0003-0170-0693(赵茂胜)

关键词: 跟腱炎, 跟腱断裂, 肌腱病, 富血小板血浆, 生长因子, 跟腱损伤, 损伤修复, 退行性病变, 血小板, 无菌性炎症

Abstract:

BACKGROUND: Platelet-rich plasma therapy provides a new direction for the healing and repair of Achilles tendon injury. Its application has become a hot topic in recent years at home and abroad, showing a good application prospect.

OBJECTIVE: To review the mechanism of action of platelet-rich plasma therapy at home and abroad and the current status and research progress of the treatment of Achilles tendinopathy.
METHODS: A computer-based retrieval of CNKI, WanFang, and PubMed databases was performed for related articles published from January 2009 to September 2018. The keywords were “platelet-rich plasma (PRP), tendinopathy, Achilles tendinitis, Achilles tendon rupture, growth factor” in Chinese and English, respectively. The articles related to platelet-rich plasma therapy, healing and repair of Achilles tendinopathy, for summary and result analysis.
RESULTS AND CONCLUSION: Forty-five eligible articles were included for analysis. The concentration of growth factors is the key to the treatment of Achilles tendon injury. Compared with conservative treatment and simple surgery, platelet-rich plasma therapy holds better imaging performance, functional scoring and quality of life. However, there is no uniform standard for preparation, concentration and injection method of platelet-rich plasma therapy in Achilles tendon injury. Platelet-rich plasma therapy still lacks clear and rigorous clinical guidelines.

Key words: Achilles tendinitis, Achilles tendon rupture, tendinopathy, platelet-rich plasma, growth factor, Achilles tendon injury, injury repair, degenerative disease, platelets, aseptic inflammation

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