中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (24): 3907-3913.doi: 10.3969/j.issn.2095-4344.0816

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨代谢调节剂参与骨关节炎的治疗:作用、问题及前景

孔庆福1,勾  禹2,田发明3,张  柳4   

  1. 1华北理工大学研究生学院,河北省唐山市  063000;2河北医科大学,河北省石家庄市  050017;3华北理工大学医学实验研究中心,河北省唐山市  063000;4华北理工大学附属医院骨科,河北省唐山市  063000
  • 收稿日期:2017-12-09
  • 通讯作者: 张柳,博士,教授,博士生导师。华北理工大学附属医院骨科,河北省唐山市 063000 共同通讯作者:田发明,博士,副教授,研究生导师,华北理工大学医学实验研究中心,河北省唐山市 063000
  • 作者简介:孔庆福,华北理工大学研究生学院,河北省唐山市063000
  • 基金资助:

    国家自然科学基金(31671235);河北省自然科学基金重点项目(H2016209176);河北省政府资助临床医学优秀人才培养和基础课题研究项目(361036);河北省第二批青年拔尖人才支持计划;唐山市科技创新团队培养计划(15130208C)

Bone metabolic modulators for osteoarthritis: curative efficacy, problems and prospects

Kong Qing-fu1, Gou Yu2, Tian Fa-ming3, Zhang Liu4   

  1. 1Graduate School, North China University of Science and Technology, Tangshan 063000, Hebei Province, China;2Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; 3Medical Research Center of North China University of Science and Technology, Tangshan 063000, Hebei Province, China; 4Department of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China
  • Received:2017-12-09
  • Contact: Zhang Liu, M.D., Professor, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, Hebei Province, China Corresponding author: Tian Fa-ming, M.D., Associate professor, Master’s supervisor, Medical Research Center of North China University of Science and Technology, Tangshan 063000, Hebei Province, China
  • About author:Kong Qing-fu, Graduate School, North China University of Science and Technology, Tangshan 063000, Hebei Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31671235; the Natural Science Foundation of Hebei Province, No. H2016209176; the Clinical Talents Training and Basic Research Project of Hebei Province, No. 361036; the Second-Batch Young Talent Support Program of Hebei Province; the Science and Technology Innovation Training Program of Tangshan, No. 15130208C

摘要:

文章快速阅读:

文题释义:
骨关节炎:是一种骨关节退化性疾病,最好的治疗方法是缓解症状的同时能够延缓甚至逆转骨关节炎的发展。
降钙素:是一种常用的抗骨再吸收剂,能够促进成骨细胞的形成刺激其活性,还能抑制破骨细胞的活性,对骨和软骨组织的合成与代谢起到重要作用。
摘要
背景:
骨关节炎是一种骨关节退化性疾病,主要表现为关节软骨退变和软骨下骨硬化,引起患者关节疼痛、功能下降。近年来,骨代谢调节剂对其治疗作用成为研究热点并应用于临床。
目的:综述应用骨代谢调节剂对骨关节炎的作用机制和治疗效果。
方法:由第一作者在PubMed和CNKI等数据库中进行文献检索,关键词为“骨关节炎、骨代谢调节剂、骨质疏松、关节、治疗、甲状旁腺激素、降钙素、二膦酸盐、选择性雌激素受体调节剂”及“Osteoporotic,bone metabolic modulators,osteoarthritis,joint,PTH,CT”等,检索时间为2000年1月到2017年6月。广泛查阅国内外有关骨代谢调节剂对骨性关节炎的作用效果及作用机制的有关文献,并进行综述。
结果与结论:骨代谢调节剂对骨关节炎关节具有保护作用,能够减缓骨关节炎软骨以及软骨下骨的破坏,稳定关节内环境,减轻骨关节炎样关节退变,阻止骨关节炎关节的破坏。此外,骨代谢调节剂联合非类固醇抗炎药可以减少相关药物的使用量,降低单一用药的不良反应,可能对骨关节炎的治疗具有更好的治疗效果。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0003-2952-242X(孔庆福)

关键词: 骨代谢调节剂, 骨关节炎, 骨质疏松, 关节, 治疗, 甲状旁腺激素, 降钙素, 二膦酸盐, 选择性雌激素受体调节剂, 组织构建

Abstract:

BACKGROUND: Osteoarthritis is a degenerative disease of the joints, mainly characterized by degeneration of articular cartilage and subchondral bone sclerosis, resulting in joint pain and decreased function in patients. In recent years, bone metabolism modulators have become a research hotspot and applied in clinic.
OBJECTIVE: To review the mechanism and curative efficacy of bone metabolic modulators for osteoarthritis.
METHODS: The first author retrieved PubMed and CNKI databases for relative articles published from January 2000 to June 2017. The keywords were “osteoporotic, bone metabolic modulators, osteoarthritis, joint, PTH, CT” in English and Chinese, respectively. The literature concerning the effects and mechanisms of bone metabolic modulators on osteoarthritis was extensively reviewed and comprehensively analyzed.
RESULTS AND CONCLUSION: Bone metabolic modulators have potential protective effects on osteoarthritic joints, preventing cartilage and subchondral bone destruction, reversing osteoarthritis-like joints change and delaying the destruction of osteoarthritic joints. The bone metabolic modulators combined with non-steroidal anti-inflammatory drugs can reduce dosages of related medicines and decrease the side effects caused by single medicine, which may have better therapeutic effects.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Tissue Engineering, Joints, Osteoporosis

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