中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (17): 2759-2765.doi: 10.3969/j.issn.2095-4344.2017.17.022

• 干细胞综述 stem cell review • 上一篇    下一篇

调节骨髓间充质干细胞成骨成脂分化的因素

周  鑫,赵佳佳,陈莉莉   

  1. 华中科技大学同济医学院附属协和医院口腔医学中心,湖北省武汉市  430022
  • 修回日期:2017-01-20 出版日期:2017-06-18 发布日期:2017-06-29
  • 通讯作者: 陈莉莉,教授,博士生导师,主任医师,华中科技大学同济医学院附属协和医院口腔医学中心,湖北省武汉市 430022
  • 作者简介:周鑫,女,1991年生,汉族,华中科技大学同济医学院附属协和医院口腔医学在读博士,主要从事间充质干细胞与组织工程的研究。
  • 基金资助:

    华中科技大学研究生创新创业基金项目(5003530004);国家优秀青年科学基金项目(31422022);国家自然科学基金重大国际与地区合作项目(31110103905)

Factors regulating the adipo-osteogenic differentiation of bone marrow mesenchymal stem cells

Zhou Xin, Zhao Jia-jia, Chen Li-li   

  1. Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • Revised:2017-01-20 Online:2017-06-18 Published:2017-06-29
  • Contact: Chen Li-li, D.D.S., Ph.D., Professor, Chief physician, Doctoral supervisor, Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • About author:Zhou Xin, Studying for doctorate, Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
  • Supported by:

    Graduates' Innovation Fund, Huazhong University of Science and Technology, No. 5003530004; the National Outstanding Youth Science Fund of China, No. 31422022; the National Natural Science Foundation of China, No. 31110103905

摘要:

文章快速阅读:

文题释义:
调控骨髓间充质干细胞成骨-成脂分化相关的信号通路:
近几十年来的研究表明,一些关键的信号通路参与调控细胞谱系的功能,包括Wnt通路、TGFβ/BMPs通路、Notch通路、FGFs通路、Hedgehogs通路等,这些信号通路也参与调节骨髓间充质干细胞成骨和/或成脂分化。
小分子化合物microRNAs (miRNAs):是一类在真核生物中内源性表达的非蛋白编码小分子RNA,长约22 nt。miRNAs广泛存在于哺乳动物各种组织内,人类基因组上大部分编码基因3’UTR上都有miRNAs的结合位点。miRNAs可通过与靶基因mRNA结合抑制靶基因蛋白转录或使mRNA降解,从而在转录后水平对靶基因表达进行调控。

 

摘要
背景:
骨髓间充质干细胞作为一类具有多向分化潜能的细胞群体,在一定诱导条件下可进行成骨或成脂分化。
目的:就骨髓间充质干细胞成骨成脂分化的双向调控影响因素研究进展作一综述。
方法:以“骨髓间充质干细胞,成骨,成脂”为中文检索词,以“bone marrow mesenchymal stem cells,osteogenic differentiation,adipocyte differentiation”为英文检索词,在中国知网期刊全文数据库和PubMed数据库检索(2006年1月至2016年8月)有关骨髓间充质干细胞成骨成脂分化的文献。
结果与结论:转录因子、信号通路、小分子化合物等是调控骨髓间充质干细胞分化方向的关键因素,这些因素不是单独发挥作用的,而是相互作用,共同调控骨髓间充质干细胞的分化方向。所以基于这些关键分子来干预骨髓间充质干细胞成骨成脂分化方向的技术,可能是将来进行细胞治疗的重要手段,进而运用于组织工程和再生医学。此外,生物钟也可通过调控相关信号通路或转录因子对其成骨成脂分化产生影响。

 

 

ORCID: 0000-0002-9348-5726(陈莉莉)

关键词: 干细胞, 骨髓干细胞, 骨髓间充质干细胞, 成骨, 成脂, 生物钟, 外泌体, 国家自然科学基金

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) with multiple differentiation potential can be induced into osteogenic or adipogenic differentiation under certain conditions.
OBJECTIVE: To review the related factors regulating the adipo-osteogenic differentiation of BMSCs.
METHODS: A computer-based search of CNKI and PubMed databases was performed for literature concerning the related factors regulating the adipo-osteogenic differentiation of BMSCs published from January 2006 to August 2016. The search terms were “bone marrow mesenchymal stem cells, osteogenic differentiation, adipocyte differentiation” in Chinese and English, respectively.
RESULTS AND CONCLUSION: Signaling pathways, transcription factors, and small molecule compounds that are interacted are key factors in the regulation of BMSCs differentiation, so the techniques to intervene BMSCs differentiation based on these key molecules may correct bone or fat abnormality and can be applied to tissue engineering and regenerative medicine in the future. Additionally, the biological clock is also one of the most important factors for adipo-osteogenic differentiation of BMSCs by regulating signaling pathways or transcription factors. 

 

 

Key words: Stem Cells, Mesenchymal Stem Cells, Adipogenesis, Tissue Engineering

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