关键词: 骨不连, 骨髓间充质干细胞, 移植, 细胞支架, 骨性愈合

Abstract:

Nonunion are treated with autogenous bone graft, etc, but due to autogenous bone graft in patients with bone greater damage can be generated for malformation, complicated by intractable pain and other symptoms, so that the clinical value is limited. Bone marrow mesenchymal stem cells are a class of self-renewal and differentiation potential of the cells, under certain induction conditions, bone marrow mesenchymal stem cells can differentiate into osteoblasts in the healing process of fracture of bone marrow mesenchymal stem cells play an important role for improving bone marrow mesenchymal stem cells into bone capability, in different ways transplantation is the focus of current research. With the development of tissue engineering techniques, bone marrow mesenchymal stem cells in stem cell scaffold material achieved good results in the treatment of nonunion. It can be used as tissue engineering scaffolds include collagen, bone morphogenetic protein, fibroin, hydroxyapatite, tricalcium phosphate, bioactive glass ceramics, calcium phosphate cement, polymer organic matter. How to choose the best scaffolds, transplant timing, cell concentration and other issues, we are still looking forward to more research assessment.