中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (22): 3571-3577.doi: 10.3969/j.issn.2095-4344.3176

• 生物材料综述 biomaterial review • 上一篇    下一篇

聚己内酯及其复合材料在组织工程骨构建中的地位与问题

张振华1，2，刘姿辰1，2，禹宝庆2   

  1. 1上海理工大学，上海市   200093；2复旦大学附属浦东医院骨科，上海市   201399
  • 收稿日期:2020-05-06 修回日期:2020-05-12 接受日期:2020-07-06 出版日期:2021-08-08 发布日期:2021-01-21
  • 通讯作者: 禹宝庆，教授，主任医师，复旦大学附属浦东医院骨科，上海市 201399
  • 作者简介:张振华，男，1995年生，山东省淄博市人，汉族，上海理工大学在读硕士，主要从事聚己内脂改性及其医学应用研究。
  • 基金资助:
    国家自然科学基金项目资助(81971753)，项目负责人：禹宝庆；上海市浦东新区卫生系统重点学科群建设项目资助(PWZxq2017-11)，项目负责人：禹宝庆；上海市医学重点专科项目资助(ZK2019C01)，项目负责人：禹宝庆；上浦东新区高原学科建设项目资助(PWYgy2018-09)，项目负责人：禹宝庆；上海市医学领军人才项目资助(046)，项目负责人：禹宝庆

Status and problems of polycaprolactone and its composite materials in bone tissue engineering

Zhang Zhenhua1, 2, Liu Zichen1, 2, Yu Baoqing2   

  1. 1University of Shanghai for Science and Technology, Shanghai 200093, China; 2Department of Orthopedics, Pudong Hospital Affiliated to Fudan University, Shanghai 201399, China
  • Received:2020-05-06 Revised:2020-05-12 Accepted:2020-07-06 Online:2021-08-08 Published:2021-01-21
  • Contact: Yu Baoqing, Professor, Chief physician, Department of Orthopedics, Pudong Hospital Affiliated to Fudan University, Shanghai 201399, China
  • About author:Zhang Zhenhua, Master candidate, University of Shanghai for Science and Technology, Shanghai 200093, China; Department of Orthopedics, Pudong Hospital Affiliated to Fudan University, Shanghai 201399, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81971753 (to YBQ); the Key Discipline Group Construction Project of Health System in Pudong New Area of Shanghai, No. PWZxq2017-11 (to YBQ); the Shanghai Key Medical Specialty Program, No. ZK2019C01 (to YBQ); the Plateau Discipline Construction Project of Shanghai Pudong New Area, No. PWYgy2018-09 (to YBQ); the Shanghai Medical Leading Talents Program, No. 046 (to YBQ)

PDF

84

摘要：

文题释义：
聚己内酯：是一种可合成的线性脂肪族聚酯，具有优异的理化性能、力学性能和生物学性能。与传统金属植入物相比，聚己内酯具有更优良的生物相容性、放射线透过性、可完全降解排出体外等特点，且越来越多的被应用于骨科及其他相关领域。
骨组织工程：是运用工程科学及生命科学的原理和方法，研究能够对人类骨组织进行修复和替代的材料的科学领域。一般来说骨组织工程包含3个主要因素：生长因子、支架材料、细胞，支架材料是其中的主体构架。

背景：随着骨组织工程领域的发展，支架材料的作用越来越体现出来，其中聚己内酯及其复合材料也越来越吸引研究人员，成为这一领域的研究热点之一。
目的：介绍聚己内酯的基本性能和合成方法，总结聚己内酯及其复合材料在骨组织工程领域的研究现状，并对未来发展和研究方向作出展望。
方法：利用计算机检索Web of Science数据库，检索词为“PCL、PCL composites、bone tissue engineering、scaffold、bone、PCL synthesis”，并以“and”为逻辑组合关系，检索时间为1950至2020年。初步检索以及筛选文献得到文献253篇，仔细阅读并筛选后对52篇文献进行综述分析。
结果与结论：①纯聚己内酯材料应用于骨组织工程中还有一定的缺点，但得益于其易于化学修饰和物理改性的特点，聚己内酯复合材料成为骨组织工程支架的备选材料之一；②由于聚己内酯优良的溶解性及热性能，可适用于多种支架制备技术，可根据施用部位选择合适的支架制备技术，目前来说也有新兴技术的出现，多种多样的支架制备技术也拓宽了聚己内酯的应用领域，所以支架制备技术也应该引起研究人员的广泛重视；③从聚己内酯的改性方向来说，无机物及天然或合成聚合物的改性已得到广泛关注；④在实验研究方法上，研究人员应注意结合临床需求引入更多种实验细胞及实验模型。
https://orcid.org/0000-0003-1770-5157 (张振华) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

关键词: 骨, 材料, 聚己内酯, 复合材料, 骨组织工程, 生物支架, 骨缺损, 骨科植入物, 综述

Abstract: BACKGROUND: With the development of bone tissue engineering, the role of scaffold materials has become more and more important. Polycaprolactone and its composite materials have also increasingly attracted researchers to become one of the research highlights in this field.
OBJECTIVE: To introduce the basic properties and synthesis methods of polycaprolactone, to summarize the research status of polycaprolactone and its composite materials in the field of bone tissue engineering, and to prospect the future development and research direction.
METHODS: These articles published from 1950 to 2020 in Web of Science database were retrieved by using the search terms “PCL, PCL composites, bone tissue engineering, scaffold, bone, PCL synthesis”, taking “and” as the logical combination relationship. Totally 253 articles were initially obtained, and finally 52 articles were reviewed and analyzed after careful reading and selection.
RESULTS AND CONCLUSION: (1) Pure polycaprolactone materials have certain shortcomings in bone tissue engineering. Due to their easy chemical modification and physical modification, polycaprolactone composite undoubtedly has become one of the candidate materials for bone tissue engineering scaffolds. (2) Due to the excellent solubility and thermal properties of polycaprolactone, it can be applied to a variety of scaffold preparation technologies. The appropriate scaffold preparation technology can be selected according to the application site. A variety of scaffold preparation technologies also broaden the application field of polycaprolactone, and there are also developed some novel technologies, so scaffold preparation technology should also attract the attention researchers. (3) For the modification direction of polycaprolactone, the modification of inorganic substances and natural or synthetic polymers has received extensive attention. (4) In terms of experimental research methods, researchers should pay attention to introducing more kinds of experimental cells and experimental models in accordance with clinical needs. 

Key words: bone, material, polycaprolactone, composite material, bone tissue engineering, biological scaffold, bone defect, orthopedic implant, review

中图分类号: