中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (28): 4566-4573.doi: 10.3969/j.issn.2095-4344.0266

• 组织构建综述 tissue construction review • 上一篇    下一篇

肌联素生物学作用及运动对其产生的影响

李  琳,于  亮   

  1. 北京体育大学运动人体科学学院,北京市   100084
  • 收稿日期:2018-01-25 出版日期:2018-10-08 发布日期:2018-10-08
  • 通讯作者: 于亮,博士,副教授,北京体育大学运动人体科学学院,北京市 100084
  • 作者简介:李琳,女,1994年生,江苏省徐州市人,汉族,北京体育大学在读硕士,主要从事骨骼肌应激条件下骨骼肌形态和机能调控研究。
  • 基金资助:

    国家自然科学基金(31500964);霍英东教育基金会(151095);国家体育总局全民健身课题(2015B046);
    北京体育大学自主科研课题(2016YB047,2017YB028)

Biological role of myonectin and its correlation with exercise

Li Lin, Yu Liang   

  1. Sport Science College, Beijing Sport University, Beijing 100084, China
  • Received:2018-01-25 Online:2018-10-08 Published:2018-10-08
  • Contact: Yu Liang, PhD, Associate professor, Sport Science College, Beijing Sport University, Beijing 100084, China
  • About author:Li Lin, Master candidate, Sport Science College, Beijing Sport University, Beijing 100084, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31500964; the Fok Ying Tung Education Foundation, No. 151095; the Nationwide Body-Building Project of General Administration of Sport of China, No. 2015B046; the Self-Dependent Research Project of Beijing Sport University, No. 2016YB047 and 2017YB028

摘要:

文章快速阅读:

文题释义:
肌联素(Myonectin):又称补体C1q/肿瘤坏死因子相关蛋白15( complement C1q/tumor necrosis factor- related protein 15,CTRP 15),是骨骼肌分泌的一种新型生物活性物质,为CTRP蛋白家族的第15位成员。
肌肉因子(Myokines):骨骼肌能够以自分泌、旁分泌和内分泌的方式调节着其他的远端器官,这些肌源性分泌因子称为“肌肉因子”(Myokines)。它们不仅作用于骨骼肌自身糖、脂肪和蛋白质代谢,还担当骨骼肌与肝脏、脂肪、心脏及大脑之间进行对话(crosstalk)的信使,调节整体代谢状况。
摘要
背景
:肌联素又称补体C1q /肿瘤坏死因子相关蛋白15,是骨骼肌分泌的一种新型生物活性物质,为CTRP蛋白家族的第15位成员。肌联素在骨骼肌中特异性表达,受机体肌纤维类型、营养条件和其他激素、细胞因子等的影响。
目的:探讨肌联素与运动的关系,为慢性疾病的治疗提供依据。
方法:应用计算机检索中国期刊全文数据库及PubMed 数据库1999至2017年18年间的文献,中文检索词为“肌肉因子,肌联素”;英文检索词为“myonkine,myonectin,erythroferrone”。依据纳入排除标准选择32篇文献进行归纳总结。
结果与结论:肌联素可通过内分泌或旁分泌的的形式入血,作用于脂肪组织和肝脏,参与脂肪组织和肝脏脂质代谢调节,肌联素可以促进脂肪酸摄入作用蛋白基因的表达,促进脂肪酸的摄取,降低血清自由脂肪酸的水平,参与肥胖和胰岛素抵抗的发生,并且与骨骼肌能量代谢有关联,参与红细胞生成过程中铁代谢的调节,因此肌联素与代谢性疾病有紧密的联系。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-9653-5741(李琳)

关键词: 肌肉因子, myonectin, 运动, 组织构建

Abstract:

BACKGROUND: Myonectin (C1q tumor necrosis factor-α-related protein isoform 15) is a novel bioactivator secreted by skeletal muscle and is the 15th member of CTRP family. Myonectin is specially expressed in skeletal muscle and its expression is affected by the type of skeletal muscle fiber, nutritional conditions, other hormones, and cytokines.
OBJECTIVE: To explore the relationship between myonectin and exercise so as to provide the basis for the treatment of chronic diseases.
METHODS: A computer-based search of CNKI and PubMed databases was performed for relevant articles published from 1999 to 2017 using the keywords of “myokine, myonectin, erythroferrone” in Chinese and English, respectively. Finally 32 eligible articles were included in result analysis in accordance with the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Myonectin is released into bloodstream through endocrine or paracrine and works on adipose tissue and liver, involved in adipose tissue and liver lipid metabolism regulation. Nevertheless, myonectin can increase the expression of fatty acid uptake protein gene, promote the uptake of fatty acids and reduce the level of free fatty acids in serum. Notably, myonectin participates in obesity and insulin resistance and correlates with skeletal muscle energy metabolism. It is also involved in erythropoiesis during the regulation of iron metabolism, and therefore, myonectin is closely related to metabolic diseases.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Sports Medicine, Muscle, Skeletal, Tissue Engineering

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