中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (2): 341-344.doi: 10.3969/j.issn.1673-8225.2012.02.034

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

腺苷酸活化蛋白激酶与骨骼肌蛋白质降解*☆

马延超1，朱  荣2，李俊平3   

  1. 1洛阳师范学院体育学院，河南省洛阳市 471022；2温州医学院，浙江省温州市325035；3北京体育大学，北京市 100084
  • 收稿日期:2011-05-13 修回日期:2011-05-23 出版日期:2012-01-08 发布日期:2012-01-08
  • 通讯作者: 李俊平，博士，讲师，北京体育大学，北京市 100084 doctorljp@126.com
  • 作者简介:马延超☆，男，1969年生，河南省洛阳市人，博士，副教授，主要研究方向为骨骼肌蛋白质代谢。yanchaoma@126.com
  • 基金资助:

    教育部博士点新教师项目(20091112120002)。

Adenosine monophosphate-activated protein kinase and myofibrillar protein degradation                              
 

Ma Yan-chao1, Zhu Rong2, Li Jun-ping3   

  1. 1College of Physical Education, Luoyang Normal University, Luoyang  471022, Henan Province, China; 2Wenzhou Medical College, Wenzhou  325035,  Zhejiang Province, China; 3Beijing Sport University, Beijing 100084, China
  • Received:2011-05-13 Revised:2011-05-23 Online:2012-01-08 Published:2012-01-08
  • Contact: Li Jun-ping, Doctor, Lecturer, Beijing Sport University, Beijing 100084, China doctorljp@126.com
  • About author:Ma Yan-chao☆, Doctor, Associate professor, College of Physical Education, Luoyang Normal University, Luoyang 471022, Henan Province, China yanchaoma@126.com
  • Supported by:

    a Project of Ministry of Education of China, No. 20091112120002

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摘要：

背景：机体运动时骨骼肌收缩，ATP被大量消耗，产生大量腺苷一磷酸，导致腺苷酸活化蛋白激酶的激活。
目的：综述不同运动过程中腺苷酸活化蛋白激酶活性的变化，以及腺苷酸活化蛋白激酶对骨骼肌蛋白质降解的研究成果。
方法：检索中国期刊网、维普期刊数据库、www.ncbi.nlm.nih.gov/pubmed和http://highwire.stanford.edu/网站与腺苷酸活化蛋白激酶、运动、蛋白质降解研究相关的文章。并对腺苷酸活化蛋白激酶的结构与作用，不同运动过程中腺苷酸活化蛋白激酶活性的变化，以及腺苷酸活化蛋白激酶升高对骨骼肌蛋白质降解的内容进行分析综述。
结果与结论：共纳入相关文献35篇。本文综述了腺苷酸活化蛋白激酶的结构、作用的研究进展；在抗阻运动和中到大强度的周期运动中，腺苷酸活化蛋白激酶活性都可能升高，而在小强度周期运动过程中腺苷酸活化蛋白激酶活性可能不升高；腺苷酸活化蛋白激酶的活化可能对骨骼肌蛋白质的降解有促进作用。

关键词: 腺苷酸活化蛋白激酶, 骨骼肌, 代谢, 运动, 结构

Abstract:

BACKGROUND: Adenosine monophosphate-activated protein kinase (AMPK) is an intracellular energy sensor in skeletal muscle, which can be activated by exercise. AMPK, widely existing in eucaryotic cells, is the serine/threonine protein kinase.
OBJECTIVE: To review the structure and the function of AMPK, changes of AMPK activity and the influence of AMPK activity on skeletal muscle protein degeneration during exercise.
METHODS: A computer-based online retrieval of China National Knowledge Infrastructure (CNKI), Vip database, http://highwire.stanford.edu and www.ncbi.nlm.nih.gov/pubmed was performed to search papers regarding AMPK and myofibrillar protein degradation. The structure and the function of AMPK, the change of AMPK activity in exercise, and the effect of AMPK activation on myofibrillar protein degradation were retrieved. 
RESULTS AND CONCLUSION: A total of 35 papers were retrieved. This study summarized the structure and the function of AMPK. In the resistance exercise and in the moderate and high intensity cycle exercise, AMPK activity may be increased, and in the low intensity cycle exercise, AMPK activity may not be increased. Activated AMPK may promote the protein degradation.
 

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