中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (18): 3407-3410.doi: 10.3969/j.issn.1673-8225.2012.18.038

• 骨髓干细胞 bone marrow stem cells • 上一篇    下一篇

修复膝关节韧带运动性损伤材料的免疫学性能★

郑丽君   

  1. 河南理工大学体育学院体质健康中心，河南省焦作市  454000
  • 收稿日期:2011-12-02 修回日期:2012-01-17 出版日期:2012-04-29 发布日期:2012-04-29
  • 作者简介:郑丽君★，女，1982年生，山东省济宁市人，汉族，硕士，讲师，主要从事运动训练与康复保健学研究。yljzlj@126.com

Immunological properties of materials for knee ligament repair following sports injury

Zheng Li-jun   

  1. Physical Health Center, College of Physical Education, Henan University of Technology, Jiaozuo  454000, Henan Province, China
  • Received:2011-12-02 Revised:2012-01-17 Online:2012-04-29 Published:2012-04-29
  • About author:Zheng Li-jun★, Master, Lecturer, Physical Health Center, College of Physical Education, Henan University of Technology, Jiaozuo 454000, Henan Province, China yljzlj@126.com

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摘要：

背景：运用材料学手段对膝关节韧带进行修复是组织工程学研究的重要内容，而材料的免疫学性能诱发的材料与人体的生物相容性问题，是制约修复成败的关键。
目的：以膝关节韧带移植材料的免疫学性能为视角，分析移植材料与人体的生物相容性。
方法：应用计算机检索PubMed、维普和万方数据库中1990-01/2012-01关于韧带损伤治疗及其移植材料免疫学性能方面的文章，在标题、摘要、全文中以“膝关节，韧带，材料，性能”或“knee，ligament，material，performance”为检索词进行检索，排除内容重复、普通综述、Meta分析类文章后筛选纳入22篇文献进行评价。
结果与结论：膝关节韧带移植材料经历了复杂而漫长的研究过程，无论自体移植、异体移植还是人工合成材料，在选用材料时良好的生物相容性是制约修复成败的关键问题。由于受生物免疫排斥等因素的影响，异种移植和人工合成材料的运用受到了限制，而目前通过对移植材料进行物理或化学改性以减小其免疫排斥反应收到了良好效果。所以，密切关注移植材料的免疫学性能，应成为今后组织工程学研究理想韧带移植材料的基础和关键环节。
 

关键词: 膝关节, 韧带, 移植, 材料, 免疫学性能

Abstract:

BACKGROUND: Use of materials science in knee ligament repair is an important part of tissue engineering, and the immunological properties of materials can induce the biocompatibility problems between the materials and human, which is the key to successful repair.
OBJECTIVE: To analyze the biocompatibility of graft materials with human being from the view of the immunological properties of knee ligament graft materials.
METHODS: A computer-based search of PubMed, VIP and Wanfang databases (1990-01/2012-01) was performed to retrieve articles about ligament injury treatment and immunological properties of graft materials. The keywords were “knee, ligament, material, performance” in Chinese and English. Repetitive articles, reviews and Meta analysis were excluded, and finally 22 articles were included in result analysis.
RESULTS AND CONCLUSION: Knee ligament graft materials have experienced a complex and lengthy research process. Good biocompatibility of graft materials (autologous grafts, allografts and synthetic materials) is the key to the successful repair. Xenograft and synthetic materials have been limited due to immune rejection, and currently, this problem is solved through physical or chemical modification to reduce the immune rejection. Therefore, we should pay attention to the immunological properties of graft materials that are the foundation and key link for ideal tissue engineering ligament graft materials in the future.

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