中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (11): 2055-2058.doi: 10.3969/j.issn.1673-8225.2012.11.036

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

运动与不同组织细胞凋亡*★

许苏旸，王文迪，付  玉，苏全生   

  1. 成都体育学院研究生部，四川省成都市 610041
  • 收稿日期:2011-09-24 修回日期:2011-10-27 出版日期:2012-03-11 发布日期:2012-03-11
  • 通讯作者: 苏全生，成都体育学院运动医学系，四川省成都市 610041
  • 作者简介:许苏旸★，男，1985年生，北京市人，汉族，成都体育学院在读硕士，主要从事运动人体科学研究。 xsy829@sohu.com
  • 基金资助:

    国家体育总局运动医学实验室重点资助项目(D210104)。

Exercise and apoptosis in different tissues

Xu Su-yang, Wang Wen-di, Fu Yu, Su Quan-sheng   

  1. Postgraduate Faculty, Chengdu Sport University, Chengdu  610041, Sichuan Province, China
  • Received:2011-09-24 Revised:2011-10-27 Online:2012-03-11 Published:2012-03-11
  • Contact: author: Su Quan-sheng, Department of Sports Medicine, Chengdu Sports University, Chengdu 610041, Sichuan Province, China
  • About author:Xu Su-yang★, Studying for master’s degree, Postgraduate Faculty, Chengdu Sport University, Chengdu 610041, Sichuan Province, China xsy829@sohu.com
  • Supported by:

    the Key Project of General Administration of Sport of China for Sports Medicine Laboratory, No. D210104*

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摘要：

背景：细胞凋亡程序可被运动刺激诱发启动造成细胞死亡。
目的：分析运动训练对不同组织细胞凋亡的影响，探讨运动训练引起的不同组织细胞凋亡与运动性疲劳，运动损伤，运动心脏重塑，运动性心肌微损伤，运动性免疫抑制的关系。
方法：应用计算机检索Medline数据库1990-01/2010-05期间运动训练与细胞凋亡关系的文章，检索词为“apoptosis”。同时检索Ginii数据库2000-01/2010-06期间运动训练与细胞凋亡关系的文章，检索词为“アポトーシス，運動”。同时计算机检索中国期刊全文数据库2000-01/2010-05期间运动训练与细胞凋亡相关的文章，检索词为“细胞凋亡，运动训练，骨骼肌，心肌，淋巴细胞，肝肾细胞”。
结果与结论：无论是单次运动还是系统运动训练，都可以对骨骼肌、心肌、肝肾及淋巴细胞的凋亡产生影响，并呈现细胞凋亡水平随运动强度的提高而提高，因此细胞凋亡与运动性骨骼肌微损伤，运动心脏重塑，运动性心肌微损伤，运动性免疫抑制的关系密切。
关键词：细胞凋亡；运动训练；骨骼肌细胞；心肌细胞；淋巴细胞
doi:10.3969/j.issn.1673-8225.2012.11.036

关键词: 细胞凋亡, 运动训练, 骨骼肌细胞, 心肌细胞, 淋巴细胞

Abstract:

BACKGROUND: Apoptotic process can be activated by evoked movement and cause cell death.
OBJECTIVE: To analyze the effects of exercise training on apoptosis in different tissues, to discuss the relationship of exercise fatigue, sports injuries, athletic heart remodeling, exercise-induced minor myocardial injury, exercise-induced immunosuppression and apoptosis in different tissues.
METHODS: An online search of Medline database was performed using key word of “apoptosis” for articles published from January 1990 to May 2010. Articles on relations between exercise training and apoptosis were included. Meanwhile, another online search of Ginii database was performed using key words of “アポトーシス，運動” for relevant articles published from January 2000 to June 2010. And a third online search of China National Knowledge Infrastructure database was performed using key words of “apoptosis, exercise training, skeletal muscle, myocardium, lymphocytes, liver and kidney cells” in Chinese for relevant articles published from January 2000 to May 2010.
RESULTS AND CONCLUSION: Single exercise and systematic exercise training both affect apoptosis in skeletal muscle, myocardium, lymphocytes, liver cells and kidney cells. Apoptosis level increases with the increasing of exercise intensity. These findings indicate that apoptosis is closely related to exercise-induced skeletal muscle micro-injury, athletic heart remodeling and exercise-induced minor myocardial injury.

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