中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (53): 10031-10034.doi: 10.3969/j.issn.1673-8225.2011.53.037

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

人肝细胞移植的临床应用

冉江华1，刘  静1，李  立1，Li Shifeng2   

  1. 1昆明市第一人民医院肝移植中心，云南省昆明市  650011
    2Oklahoma Transplant Center, Oklahoma University Medical Center，Oklahoma City，OK 73104，USA
  • 收稿日期:2011-07-12 修回日期:2011-10-10 出版日期:2011-12-31 发布日期:2011-12-31
  • 作者简介:冉江华★，男，1965年生，博士，主任医师，教授，硕士研究生导师，主任，主要从事器官移植方面的研究。 lqzkm@163.com

Clinical application of human hepatocyte transplantation

Ran Jiang-hua1, Liu Jing1, Li Li1, Li Shi-feng2   

  1. 1Liver Transplant Center, First People’s Hospital in Kunming, Kunming  650011, Yunnan Province, China
    2Oklahoma Transplant Center, Oklahoma University Medical Center, Oklahoma City, OK  73104, USA
  • Received:2011-07-12 Revised:2011-10-10 Online:2011-12-31 Published:2011-12-31
  • About author:Ran Jiang-hua☆, Doctor, Chief physician, Professor, Master’s supervisor, Liver Transplant Center, First People’s Hospital in Kunming, Kunming 650011, Yunnan Province, China lqzkm@163.com

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摘要：

背景：目前的人肝细胞来源主要是在器官移植过程中供者的肝脏不适用于肝移植的边缘性肝脏,故其限制了向临床提供良好功能的肝细胞源。
目的：阐述人肝细胞移植的临床现状和面临的挑战，对人肝细胞移植的临床应用和面临的困难进行总结。
方法：应用计算机检索万方、维普和PubMed数据库中1990-01/2010-09关于肝细胞移植方面的文章，在标题和摘要中以“肝细胞；移植；肝衰竭；肝细胞源”或“hepatocyte transplantation; Liver failure;Liver-based metabolic disorders”为检索词进行检索。选择文章内容肝细胞移植相关，同一领域文献则选择近期发表或发表在权威杂志文章，排除陈旧和重复性研究文献。
结果与结论：初检得到213篇文献，根据纳入标准选择30篇文章进行综述。全球已有超过80例肝脏代谢性疾病和肝衰竭的患者接受了人肝细胞移植，移植后，初步早期的临床结果显示肝脏功能得到不同程度的改善，治疗的结果表明其广泛的临床应用是很有前景的。但进一步开发并完善肝细胞源是现阶段的最大挑战，移植的人肝细胞整合到受者肝脏内而存活的过程也需要进一步地完善。

关键词: 人肝细胞, 移植, 肝衰竭, 肝性代谢性疾病, 肝细胞源

Abstract:

BACKGROUND: Now, source of human hepatocyte is mainly from the marginal donor liver that unused or deemed unsuitable for liver transplantation. Hence the major obstacle for the wide clinic application of human hepatocyte transplantation is the limited supply of donor liver that can provide good quality cells.
OBJECTIVE: To review the clinical actuality and challenge of human hepatocytes transplantation and to summarise the clinical application and difficulty of human hepatocytes transplantation.
METHODS: Wanfang, VIP and PubMed databases were searched from January1990 to September 2010 for literatures concerning human hepatocyte transplantation with the key words of “hepatocyte, transplant, liver failure, hepatocyte source” or “hepatocyte transplantation; liver failure; liver-based metabolic disorders” in Chinese and in English. The articles related to the research on the human hepatocyte transplantation were selected; articles in the same circle published in recent years or in authorized journals. Older articles and repetitive studies were excluded.
RESULTS AND CONCLUSION: Among 213 articles, only 30 met the requirement. Over 80 patients have received human hepatocyte transplantation to treat liver-based metabolic disorders and liver failure around the world. After transplantation, it has shown some early improvement in liver function which showed that hepatocyte transplantation has a wide clinical application. The major challenge is to develop an alternative source of hepatocytes and the survival course of human hepatocytes transplanted into donor liver also need to further improve.

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