中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9283-9286.doi: 10.3969/j.issn.1673-8225.2011.49.038

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

中药对间充质干细胞培养分化及干细胞移植治疗心脑血管疾病的影响

石景洋，唐学敏   

  1. 南阳理工学院张仲景国医学院临床教研室，河南省南阳市  473000
  • 收稿日期:2011-09-15 修回日期:2011-11-18 出版日期:2011-12-03 发布日期:2011-12-03
  • 作者简介:石景洋，男，1965年生，河南省南阳市人，汉族，1989年河南中医学院毕业，副主任医师，副教授，临床教研室主任，主要从事中西医结合中风病治疗方面的研究。 sjy901512@163.com

Influence of Chinese medicines on mesenchymal stem cells culture and differentiation as well as stem cells transplantation for cardio-cerebrovascular diseases

Shi Jing-yang, Tang Xue-min   

  1. Clinical Teaching and Research Section, Zhangzhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang 473000, Henan Province, China
  • Received:2011-09-15 Revised:2011-11-18 Online:2011-12-03 Published:2011-12-03
  • About author:Shi Jing-yang, Associate chief physician, Associate professor, Clinical Teaching and Research Section, Zhangzhongjing Traditional Chinese Medicine College, Nanyang Institute of Technology, Nanyang 473000, Henan Province, China sjy901512@163.com

PDF

349

被引次数

10

摘要：

背景：中药及其复方对间充质干细胞增殖与分化有促进作用，而干细胞在一定条件下，可分化为心肌样细胞和神经样细胞，并对心脑血管疾病有明显改善。
目的：文章就近年中药对不同来源干细胞干预的影响进行探讨，并分析了干细胞在心脑血管疾病领域的应用。
方法：由第一作者于2011-08应用计算机检索万方数据库和维普数据库相关文献，检索时间为1990/2011-08；检索词为“中药，干细胞，增殖，分化，作用靶点”。纳入标准：①中药参与干细胞增殖分化的文章。②中药干预干细胞移植治疗脑缺血或脑损伤的研究。③中药干预的干细胞治疗心血管疾病的相关文章。阅读标题和摘要进行筛选，共纳入30篇用于文献分析。
结果与结论：中药既可以直接作用于体内的干细胞，促进其增殖、分化，也可以影响其微环境，促进其存活与功能建立，或者调整机体的免疫功能，减轻或消除免疫排斥反应。虽然干细胞移植与中药联合运用治疗心脑血管疾病的相关研究目前还不多，但却已逐渐显示出其独特的临床应用价值，如果能利用中医理论促进干细胞移植对相关疾病的治疗作用，发挥中西医结合的优势，那么既为干细胞移植建立了新方法，又为中医药走向生命科学研究前沿开辟一条新的有效的途径。

关键词: 中药, 间充质干细胞, 移植, 增殖, 分化, 作用靶点

Abstract:

BACKGROUND: Chinese medicine and compound recipe can promote mesenchymal stem cells proliferation and differentiation. Under certain condition, MSCs can differentiate into cardiomyocyte-like cells and neural-like cells and improve cardio-cerebrovascular disease.
OBJECTIVE: To discuss influence of Chinese medicines on different source-derived stem cells and analyze application of stem cells in cardio-cerebrovascular diseases.
METHODS: A computer-based online search of Wanfang and VIP database was performed for related articles published between 1990 and 2011 with key words “Chinese medicine, stem cell, proliferation, differentiation, target” in Chinese. Articles regarding roles of Chinese medicines in stem cells proliferation and differentiation, transplantation of stem cells for brain ischemia or brain injury in combination with Chinese medicines, and Chinese medicine-treated stem cells for cardiovascular diseases, were included. After reading the titles and abstracts, 30 articles were analyzed.
RESULTS AND CONCLUSION: Chinese medicines can directly target to stem cells in vivo to promote their proliferation and differentiation and can change microenvironment of stem cells to promote cells survival and functional building or regulate immune function to relieve or eliminate rejection. Although stem cells transplantation has not frequently used in combination with Chinese medicines for cardio-cerebrovascular diseases, they have exhibited special clinical values. Therefore, transplantation of stem cells in combination with traditional Chinese medical theory may provide novel approaches for stem cells transplantation and effective methods for application of Chinese medicines in life science domains.  

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