中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9271-9274.doi: 10.3969/j.issn.1673-8225.2011.49.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞在组织工程研究中的应用进展

赵大成，汪玉良，党跃修，赵  琳   

  1. 兰州大学第二医院骨科，甘肃省兰州市  730020
  • 收稿日期:2011-06-01 修回日期:2011-07-18 出版日期:2011-12-03 发布日期:2011-12-03
  • 通讯作者: 汪玉良，硕士生导师，主任医师，兰州大学第二医院骨科，甘肃省兰州市730020 wyl60918@sina.com
  • 作者简介:赵大成★，男，1984年生，甘肃省定西市人，汉族，兰州大学第二医院在读硕士，主要从事骨科方面的研究。 zhaodacheng09@163.com
  • 基金资助:

    甘肃省自然科学研究基金(2009GS02583)。

Application progress of bone marrow mesenchymal stem cells in tissue-engineering research

Zhao Da-cheng, Wang Yu-liang, Dang Yue-xiu, Zhao Lin   

  1. Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou  730020, Gansu Province, China
  • Received:2011-06-01 Revised:2011-07-18 Online:2011-12-03 Published:2011-12-03
  • Contact: Wang Yu-liang, Master's supervisor, Chief physician, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730020, Gansu Province, China wyl60918@sina.com
  • About author:Zhao Da-cheng★, Studying for master’s degree, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730020, Gansu Province, China zhaodacheng09@163.com
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 2009GS02583*

PDF

350

被引次数

5

摘要：

背景：骨髓间充质干细胞作为良好的种子细胞在组织工程中发挥着重要的作用。
目的：描述骨髓间充质干细胞在在骨、软骨、肝、肌腱及心脏组织工程应用的实验现状，阐明骨髓间充质干细胞在组织工程中发挥的作用。
方法：以检索词“bone marrow mesenchymal stem cells，mesenchymal stem cells，tissue engineering”，应用计算机检索NCBI、PubMed数据库 2000-01/2010-10关于骨髓间充质干细胞应用于组织工程方面文章，并限定文章语言种类为English，排除重复性研究和缺乏原创性的研究。
结果与结论：共纳入33篇文献进行归纳分析。骨髓间充质干细胞增殖活跃、且具有多向分化潜能，在特定的条件下可以分化为成骨细胞、软骨细胞、肝细胞、肌腱细胞及心肌细胞。因此，骨髓间充质干细胞可作为良好的种子细胞应用于组织工程，治疗临床相关疾病。结果证实骨髓间充质干细胞在组织工程中有很高的应用价值，希望在相关疾病的治疗上能应用组织工程解决存在的难题。

关键词: 骨髓间充质干细胞, 组织工程, 分化, 应用进展, 综述文献

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) play a significant role in tissue engineering as good seed cells.
OBJECTIVE: To descript the experimental status of BMSCs in the bone, cartilage, liver, tendons and heart tissue engineering applications, clarify the momentousness role of BMSCs in tissue engineering.
METHODS: A computer-based online search was conducted in NCBI database and PubMed database for literatures about the application of BMSCs in tissue engineering published from January 2000 to October 2010 with the key words of “Bone marrow mesenchymal stem cells, Mesenchymal stem cells, tissue engineering” in English. Exclusive criteria included repetitive studies and no original research.
RESULTS AND CONCLUSION: According to the included and excluded criterion, a total of 33 references were selected to analysis. BMSCs proliferation activity, had potentiality of multi-directional differentiation, it could differentiated to osteoblasts, chondrocytes, hepatocytes, tendon cells and myocardial cells. Therefore, BMSCs might be favorable seed cell to utilize in tissue engineering, and treated clinical correlated diseases. This article confirmed BMSCs had a highly utilization value in tissue engineering, and was hoped to solve puzzlers problems applied with tissue engineering in the treatment of related diseases.

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