中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (44): 8337-8340.doi: 10.3969/j.issn.1673-8225.2011.44.042

• 器官移植临床实践 clinical practice of organ transplantation • 上一篇    下一篇

Rh(D)血型不合的肝移植临床分析

尚丽明，彭民浩，覃  晓，郭  雅，肖开银，彭  涛   

  1. 广西医科大学第一附属医院肝胆外科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-06-26 修回日期:2011-07-16 出版日期:2011-10-29 发布日期:2011-10-29
  • 通讯作者: 彭涛，教授，博士后，博士生导师，广西医科大学第一附属医院肝胆血管外科，广西壮族自治区南宁市 530021 pengtaocn@ hotmail.com
  • 作者简介:尚丽明★，男，1976年生，山西省平定市人，汉族，2004年广西医科大学毕业，硕士，主治医师，主要从事肝脏外科，肝移植研究。 sxyqslm@163.com
  • 基金资助:

    广西医疗卫生重点科研基金项目(重201018)。

Clinical analysis of Rh (D) incompatibility in a liver transplantation patient

Shang Li-ming, Peng Min-hao, Qin Xiao, Guo Ya, Xiao Kai-yin, Peng Tao   

  1. Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning   530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-26 Revised:2011-07-16 Online:2011-10-29 Published:2011-10-29
  • Contact: Peng Tao, Doctor, Professor, Doctoral supervisor, Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China pengtaocn@hotmail.com
  • About author:Shang Li-ming★, Master, Attending physician, Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China sxyqslm@163.com
  • Supported by:

    Scientific Research Foundation Key Program of Guangxi Medical Care and Health, No.Zhong201018*

PDF

448

被引次数

11

摘要：

背景：血型不合器官移植可能发生严重的排斥反应、移植物抗宿主病及溶血反应。
目的：回顾分析Rh(D)阴性肝癌患者接受Rh(D)阳性供肝移植的方法及疗效，并结合文献复习探讨该方法的可行性。
方法：1 例Rh(D)阴性肝癌患者接受Rh(D)阳性供肝移植过程中，应保证供肝的良好灌洗，尽量减少出血，缩短手术时间，移植中移植后输注适量的异型红细胞及血浆。
结果与结论：肝移植后，受者肝功能恢复正常，未发生急慢性排斥反应及输血相关并发症。随访1年，受者存活良好。说明在无合适供体的情况下，只要供肝得到充分灌洗、移植中控制出血、移植后采用合理的免疫抑制方案，Rh(D)阴性肝病患者移植Rh(D)阳性供肝可达到良好效果。

关键词: 肝移植, Rh(D)血型系统, 血型不合, 器官移植

Abstract:

BACKGROUND: Blood type incompatibility organ transplantation can result in severe rejection, graft versus host disease and hemolytic reaction.
OBJECTIVE: To retrospectively analyze the liver transplantation method of RH(D)-negative patients with liver cancer using the RH (D)-positive donor and to investigate the feasibility of the method of transplantation based on related literatures.
METHODS: One donor liver with Rh (D)-positive was transplanted to a patient of liver cancer with Rh (D)-negative. Then the donor liver with Rh (D)-positive was well lavaged, bleeding in operation should be minimized, and products of blood with Rh (D)-positive was infused. Follow-up and effects were observed.
RESULTS AND CONCLUSION: One donor liver with Rh (D)-positive was successfully transplanted to a patient of liver cancer with Rh (D)-negative. The operation was smoothly performed. There were no acute and chronic rejection and blood transfusion-related complications after operation. The patient has survived for 1 year with normal liver function. These finding suggest that because there are no acute and chronic rejection and blood transfusion-related complications happened, so a donor liver with Rh (D)-positive can be transplanted into a patient with liver cancer with Rh (D)-negative blood after full irrigation and good clinical results have been acquired.

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