中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (10): 1859-1862.doi: 10.3969/j.issn.1673-8225.2011.10.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

神经干细胞与运动性神经疾病

曾  宇   

  1. 广西师范大学体育学院，广西壮族自治区桂林市   541004
  • 收稿日期:2010-10-10 修回日期:2010-12-26 出版日期:2011-03-05 发布日期:2011-03-05
  • 作者简介:曾宇★，男，1980年生，广西壮族自治区容县人，汉族，2009年广西师范大学毕业，硕士，主要从事运动性疾病康复方面的研究。 mdchgyffs@126.com

Neural stem cells and exercise-induced neurological disease

Zeng Yu   

  1. Institute of Physical Education, Guangxi Normal University, Guilin  541004, Guangxi Zhuang Autonomous Region, China
  • Received:2010-10-10 Revised:2010-12-26 Online:2011-03-05 Published:2011-03-05
  • About author:Zeng Yu★, Master, Institute of Physical Education, Guangxi Normal University, Guilin 541004, Guangxi Zhuang Autonomous Region, China mdchgyffs@126.com

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摘要：

背景：神经干细胞以其所具有的多向分化潜能、自我更新、迁徙性、低免疫性等特点受到临床的广泛应用，但有关神经干细胞在运动医学领域用于防治运动性损伤等的研究成果不是很多。
目的：旨在通过分析神经干细胞的生物学特性，探讨其在临床上的应用，为神经性疾病的预防和治疗提供理论依据。
方法：应用计算机检索CNKI和PubMed数据库中1997-01/2010-10关于神经干细胞与运动性神经疾病的文章，在标题和摘要中以“神经干细胞，运动医学，失神经肌萎缩，周围神经损伤”或“Neural Stem Cell，Sports Medicine，Denervation Muscle Atrophy，Peripheral Nerve Injury”为检索词进行检索，选择文章内容与神经干细胞和运动性神经疾病相关，同一领域文献选择近期发表或发表在权威杂志上的文章，初检得到262篇文献，根据纳入标准选择31篇进行综述。
结果与结论：神经干细胞以其多向分化潜能、自我维持和更新、低免疫原性、迁徙性和来源广泛等特点为其在治疗神经退行性病变、运动性骨骼肌失神经肌萎缩和促运动性周围神经损伤的再生等提供了较为广阔的应用前景，但由于基础性研究所限，对其作用机制、诱导分化、迁移等仍有待大量的实验研究予以证实。

关键词: 神经干细胞, 运动医学, 失神经肌萎缩, 周围神经损伤, 再生

Abstract:

BACKGROUND: Neural stem cells are characterized by multi-directional differentiation potential, self-renewal, migration, low immunity, which has been widely used in clinical practice. However, there are rare researches addressing neural stem cells in the field of sports medicine for sports injury prevention.
OBJECTIVE: To explore the clinical applications of neural stem cells through its biological characteristics, and provides a theoretical basis for sports injury prevention and treatment.
METHODS: The articles related to neural stem cells and exercise-induced neurological disease in CNKI database and PubMed database from January 1997 to October 2010 were retrieved with the key words of “Neural Stem Cell, Sports Medicine, Denervation Muscle Atrophy, Peripheral Nerve Injury” in Chinese or in English. The contents of articles concerning neural stem cells and exercise-induced neurological disease, and recently published or published in the authoritative magazines in the same field were selected. A total of 262 literatures were obtained from computer screen, and 31 documents of them were involved for summarization according to inclusion criteria.
RESULTS AND CONCLUSION: Neural stem cells are characterized by multi-directional differentiation potential, self-remaining and renewal, low immunity, migration, and wide variety of sources, which provide a more broad application prospects for the treatment of neurodegenerative diseases, exercise-induced skeletal muscle atrophy, and promote the sport of the regeneration of peripheral nerve injury. But because of the limited basic research, its mechanism of action, induced differentiation, migration need to be confirmed.

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