中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (51): 9675-9678.doi: 10.3969/j.issn.1673-8225.2010.51.041

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同诱导材料修复骨损伤的生物相容性分析

王庆丰   

  1. 河南理工大学体育学院，河南省焦作市 454000
  • 出版日期:2010-12-17 发布日期:2010-12-17
  • 作者简介:王庆丰，男， 1969年生，河南省濮阳人，汉族，副教授，主要从事运动训练与体育保健学的研究。

Biocompatibility of different induction materials for bone injury repair

Wang Qing-feng   

  1. Physical Education College, Henan Polytechnic University, Jiaozuo   454000, Henan Province, China
  • Online:2010-12-17 Published:2010-12-17
  • About author:Wang Qing-feng, Associate professor, Physical Education College, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China

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摘要：

目的：对组织工程康复手段康复过程中生物材料生物相容性的必要性和重要性进行阐述。
方法：第一作者应用计算机检索PubMed数据库及CNKI数据库，在标题和摘要中以“急性损伤，骨，生物材料”或“Acute Injury，Bone，Biological Materials”为检索词进行检索。选择内容与骨急性损伤治疗手段、材料学特点、生物相容性及其应用效果相关文献，共纳入20篇文献进行分析。
结果：早期组织工程学骨组织治疗手段以自体移植与异体移植为主，这两种移植均存在缺陷，前者易对患者造成二次伤害，后者面临较大的生物安全隐患，因此人工骨组织修复生物医用材料越来越受到临床青睐。目前所用的骨移植人工生物材料主要包括：骨衍生材料、高分子材料、无机材料和复合材料等，这类材料具有对机体组织进行修复、替代与再生的作用，其中生物材料是否具备良好的生物相容性，对其运用的成败起到至关重要的作用。
结论：理想生物材料的选择必须重视其良好的生物相容性，其生物相容性的好坏直接决定着骨康复治疗的效果，可以说良好的生物相容性应是组织工程治疗手段过程中生物材料选择的基础和必要条件。

关键词: 急性损伤, 骨, 生物材料, 康复, 生物相容性

Abstract:

OBJECTIVE: To elaborate the necessity and importance of understanding the biocompatibility of biomaterials in tissue engineering rehabilitation process.
METHODS: A computer-based online search of PubMed database and CNKI database was performed by the first author, using the key words of “acute injury, bone, biological material” in English and in Chinese to search the title and abstract. Articles related to treatment approach of acute bone injury, materials science characteristics, biocompatibility and its application effect were selected, a total of 20 articles were included in analysis.
RESULTS: Early treatments for bone tissue engineering are autologous and allogeneic transplantations, both are defective, the former is easy to cause secondary injury in patients, the later is faced with greater bio-security risk, so artificial biomaterials for bone tissue repair has been attracting more and more attention in clinical practice. Currently artificial bone graft biomaterials include bone-derived materials, polymer materials, inorganic materials and composite materials, these materials have a repair, replacement and regeneration effect on the body tissue, in which a good biocompatibility of the biomaterials plays a vital role in the application success.
CONCLUSION: The ideal choice of biomaterials must attach importance to its good biocompatibility, which directly determines the rehabilitation of bone, a good biocompatibility is the basis and the necessary conditions for biomaterials choice in tissue engineering treatment process.

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