中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (38): 7136-7140.doi: 10.3969/j.issn.1673-8225.2010.38.026

• 生物材料综述 biomaterial review • 上一篇    下一篇

壳聚糖微粒载蛋白质药物：黏膜传输蛋白质及抗体的明星材料

黄  霞1,2，陈家昌3，吕蕾蕾1，张勤星2，张世勋2，申长雨2   

  1. 1郑州大学材料科学与工程学院，河南省郑州市   450002；2郑州大学国家橡塑模具工程中心，河南省郑州市 450002；   3西安交通大学材料科学与工程学院，陕西省西安市    710049
  • 出版日期:2010-09-17 发布日期:2010-09-17
  • 作者简介:黄霞☆，女，1978年生，湖北省公安县人，汉族，2008年西安交通大学毕业，博士，讲师，主要从事生物医用高分子材料的研究。 happyhxia@163.com
  • 基金资助:

    国家自然科学基金资助项目(10590352) 。

Chitosan microparticles carrying protein drugs: Mucosal transmission protein and antibody biomaterials

Huang Xia 1,2, Chen Jia-chang3, Lü Lei-lei1, Zhang Qin-xing2, Zhang Shi-xun2, Shen Chang-yu2   

  1. 1 School of Materials Science and Engineering, Zhengzhou University, Zhengzhou   450002, Henan Province, China; 2 National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou   450002, Henan Province, China; 3 College of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an   710049, Shaanxi Province, China
  • Online:2010-09-17 Published:2010-09-17
  • About author:Huang Xia☆, Doctor, Lecturer, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450002, Henan Province, China; National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, Henan Province, China happyhxia@163.com
  • Supported by:

    the National Natural Science Foundation of China, No.10590352*

PDF

474

摘要：

背景：载蛋白质、肽类药物及靶向传输是药物载体研究的热点与难点，壳聚糖作为一种天然阳离子聚合物，生物降解性、相容性、力学性能俱佳，是生物大分子及活性物质的最佳载体材料之一。  
目的：分析壳聚糖在蛋白质载体领域的优势，综述壳聚糖及其衍生物在载蛋白质及肽类药物方面的研究成果。
方法：检索中国知网、elsevier、willey等中外文全文数据库有关壳聚糖载蛋白质药物、释药及微粒制剂的内容，检索时间为2005/2010，英文检索词为“chitosan/chitin，microspheres，biomaterial，biopolymer，drug carrier，drug delivery，cell adhesion，ECM，peptide，chemical modification，bioactivity，protein drug，gene delivery，micro-and nanoparticles”；中文检索词为“甲壳素/壳聚糖，微球/微粒/微囊，载体，生物大分子，基因治疗，蛋白质药物，细胞外基质，生物活性，生物相容性，生物降解”。
结果与结论：蛋白质及肽类药物具有疗效好、剂量小、毒副作用小的显著优势，但蛋白质稳定性差、难吸收、体内生物半衰期短的缺点是此类药物使用的巨大障碍。聚合物载药的研究虽多见报道，但在传输蛋白质、肽类药物方面依然面临诸多困难。壳聚糖及壳聚糖衍生物因其卓越的促进吸附性能称为黏膜传输蛋白质及抗体的明星材料，但在制剂的稳定性及定量精确释放等方面仍存在很多挑战。

关键词: 壳聚糖, 生物降解, 微粒, 载体, 蛋白质药物

Abstract:

BACKGROUND: The target delivery of proteins/peptides drug is a difficulty in the field of drug carriers. As one of positive ion polymer, chitosan has great the biological degradability, compatibility, and mechanical properties. It is known as one of most promising carrier materials of biological macromolecules and active materials.
OBJECTIVE: To analyze the superiority of chitosan as a protein carrier, to review the research progress of chitosan and its derivates in protein and peptide drug carrier.
METHODS: A computer-based online search of CNKI, Elsevier and Willey databases between 2005 and 2010 was performed for English and Chinese articles about the chitosan carrier of protein drugs, drug release and microparticles using the key words “chitosan/chitin, microspheres, biomaterial, biopolymer, drug carrier, drug delivery, cell adhesion, ECM, peptide, chemical modification, bioactivity, protein drug, gene delivery, micro- and nanoparticles” in English and “chitosan/chitin, microspheres, carrier, biomacromolecule, gene therapy, protein drug, ECM, bioactivity, biocompatibility, biodegradation” in Chinese.
RESULTS AND CONCLUSION: Protein and peptide drug has good curative effect, small dose, and few side effects, but poor protein stability and absorption, as well as short biological half-life in vivo are big obstacle for drug use. Many results report polymer drug carrier, but there are still some problems in many aspects of protein and peptide drug transport. Because of excellent promotion adsorption performance, chitosan and chitosan derivatives are regarded as mucous transport proteins and antibody materials, but the stability and quantitative accurately releasing in the preparation still face many challenges.

中图分类号: