中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (2): 311-316.doi: 10.3969/j.issn.2095-4344.2951

• 组织构建综述 tissue construction review • 上一篇    下一篇

细胞自噬过程、通路、调控及其与肺动脉高压的多重相关性

陈辛玲, 王生兰   

  1. 青海大学，青海省西宁市   810016
  • 收稿日期:2020-01-07 修回日期:2020-01-15 接受日期:2020-03-18 出版日期:2021-01-18 发布日期:2020-11-21
  • 通讯作者: 王生兰，教授，青海大学，青海省西宁市 810016
  • 作者简介:陈辛玲，女，1995年生，甘肃省武威市人，汉族，青海大学在读硕士，主要从事高原心血管疾病研究。
  • 基金资助:
    国家自然科学基金 (81860076)

Cell autophagy, pathway, regulation and its multiple correlations with pulmonary hypertension

Chen Xinling, Wang Shenglan   

  1. Qinghai University, Xining 810016, Qinghai Province, China
  • Received:2020-01-07 Revised:2020-01-15 Accepted:2020-03-18 Online:2021-01-18 Published:2020-11-21
  • Contact: Wang Shenglan, Professor, Qinghai University, Xining 810016, Qinghai Province, China
  • About author:Chen Xinling, Master candidate, Qinghai University, Xining 810016, Qinghai Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81860076

PDF

115

摘要：

文题释义：
细胞自噬：是真核生物中进化保守的对细胞内物质进行周转的重要过程。该过程中一些损坏的蛋白或细胞器被双层膜结构的自噬小泡包裹后，送入溶酶体(动物)或液泡(酵母和植物)中进行降解并得以循环利用。
肺动脉高压：指肺动脉压力升高超过一定界值的一种血流动力学和病理生理状态，可导致右心衰竭，可以是一种独立的疾病，也可以是并发症，还可以是综合征。其血流动力学诊断标准为：海平面静息状态下，右心导管检测肺动脉平均压≥25 mm Hg。

背景：细胞自噬是真核细胞高度保守的溶酶体降解途径，主要用于降解细胞内长寿命的蛋白质、受损的细胞器、细胞内入侵的病原微生物等。近年的研究表明细胞自噬在肺动脉高压的发生发展中具有举足轻重的作用，因而阐明细胞自噬的分子机制对肺动脉高压的治疗至关重要。
目的：归纳自噬的过程和细胞信号通路对自噬的调控，整理自噬在肺动脉高压中的作用，提出研究细胞自噬的方法。
方法：在CNKI、万方、维普输入检索式“细胞自噬AND细胞信号通路”，在PubMed中输入检索式 “(“Autophagy”[Mesh]) AND“Signal Transduction”[Mesh]”“(“Hypertension, Pulmonary”[Mesh]) AND“Autophagy”[Mesh]”通过搜索后阅读标题及摘要进行初步筛选，排除陈旧及质量差的文献，最终共纳入44篇文献进行结果分析。
结果与结论：近年来研究发现自噬与诸多疾病有关，自噬是否具有保护作用或有害作用尚未明确。细胞信号通路对某疾病自噬调控的研究主要有：①阐明细胞信号通路对自噬的影响；探讨细胞信号通路蛋白和细胞自噬蛋白上下游的关系；②说明某物质对细胞自噬及信号通路的影响，及该物质调控细胞自噬可能是通过某通路引起的。
https://orcid.org/0000-0001-5420-8091 (王生兰) 

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 自噬, 自噬的过程, PI3K/AKT/mTOR信号通路, JNK信号通路, P38MAPK信号通路, ERK信号通路, NF-κB 信号通路, 肺动脉高压

Abstract: BACKGROUND:  Autophagy is a highly conserved lysosome degradation pathway in eukaryotic cells, which is mainly used to degrade intracellular long-lived proteins, damaged organelles, invasive pathogenic microorganisms, and so on. Recent studies have shown that cell autophagy plays an important role in the occurrence and development of pulmonary hypertension, so elucidating the molecular mechanism of cell autophagy is particularly important for the treatment of pulmonary hypertension.
OBJECTIVE: To generalize the process of autophagy and the regulation of cell signaling pathways on autophagy, to summarize the effect of autophagy in pulmonary hypertension, and to put forward methods to study cell autophagy.
METHODS: With the search formula “Cell Autophagy and Cell Signaling Pathway”, CNKI, WanFang, and VIP were retrieved, and with the search formula “(“ Autophagy “[Mesh]) AND” Signal Transduction “[Mesh]” and “(“Hypertension, Pulmonary”[Mesh]) AND “Autophagy”[Mesh],’’ PubMed was searched. After preliminary screening of the title and abstract to exclude stale and poor-quality literature, a total of 44 literatures were included for analysis.
RESULTS AND CONCLUSION: In recent years, studies have found that autophagy is related to many diseases, and it is unknown about whether autophagy has protective or harmful effects. Many signaling pathways have participated in and regulated autophagy. This paper clarifies the effect of cell signaling pathways on autophagy; explores the relationship between cell signaling pathway proteins and the upstream and downstream of cell autophagy proteins; elucidates the influence of a substance on cell autophagy and signaling pathway, and  the substance maybe regulates cell autophagy via a certain pathway. 

Key words: autophagy, process of autophagy, PI3K/AKT/mTOR signaling pathway, JNK signaling pathway, P38MAPK signaling pathway, ERK signaling pathway, NF-κB signaling pathway, pulmonary hypertension

中图分类号: