中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (2): 276-282.doi: 10.12307/2022.045
• 组织构建综述 tissue construction review • 上一篇 下一篇
孙友强1,马 超2,梁萌梦3,辛鹏飞2,张 华1,向孝兵1
收稿日期:
2020-10-20
修回日期:
2020-10-28
接受日期:
2020-11-28
出版日期:
2022-01-18
发布日期:
2021-10-27
通讯作者:
向孝兵,博士,主任医师,广州中医药大学第一附属医院运动医学科,广东省广州市 510405
作者简介:
孙友强,男,1988年生,江西省瑞昌市人,汉族,2018年广州中医药大学毕业,博士,主治医师,主要从事肩袖损伤与股骨头坏死的基础与临床研究。
基金资助:
Sun Youqiang1, Ma Chao2, Liang Mengmeng3, Xin Pengfei2, Zhang Hua1, Xiang Xiaobing1, *
Received:
2020-10-20
Revised:
2020-10-28
Accepted:
2020-11-28
Online:
2022-01-18
Published:
2021-10-27
Contact:
Xiang Xiaobing, MD, Chief physician, Department of Sports Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
About author:
Sun Youqiang, MD, Attending physician, Department of Sports Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
摘要:
文题释义:
自噬:当细胞面临外部环境压力(例如缺乏营养、缺氧、损伤等)时,它们可以使用溶酶体依赖性途径来破坏细胞,回收细胞器、有机物以满足自己的需求,这种现象称为自噬。
骨组织:骨组织的细胞成分主要包括骨髓间充质干细胞、成骨细胞、骨细胞和破骨细胞。成骨细胞主要合成骨基质,破骨细胞具有骨吸收功能,生理状态下,骨组织的生成和吸收处于动态平衡中。
背景:自噬对维持细胞稳态和应激敏感性有重要作用,作为细胞清除受损细胞器并实现细胞成分再循环的一种重要方式,在骨代谢中发挥着不可或缺的作用。
目的:对自噬对骨髓间充质干细胞、成骨细胞、骨细胞以及破骨细胞的作用机制进行综述,以明确自噬在调节和维持骨组织细胞活性和功能等方面的意义。
方法:以关键词“autophagy;bone marrow mesenchymal stem cells;osteoblasts;osteocytes;osteoclasts”计算机检索PubMed数据库与骨细胞自噬相关的研究。
结果与结论:最终纳入84篇文献。发现自噬在骨代谢具有重要作用。自噬参与保持矿化和吸收的平衡,继而维持骨稳态。适当的自噬诱导剂也可能有益于骨骼重塑。自噬异常会导致骨骼平衡紊乱,导致骨质疏松等疾病。通过调节自噬维持骨稳态代谢平衡,可有助于预防或治疗骨相关疾病。
https://orcid.org/0000-0001-8935-5374 (Sun Youqiang)
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
中图分类号:
孙友强, 马 超, 梁萌梦, 辛鹏飞, 张 华, 向孝兵. 自噬在骨细胞中重要作用的最新研究进展:骨相关细胞活性和骨代谢[J]. 中国组织工程研究, 2022, 26(2): 276-282.
Sun Youqiang, Ma Chao, Liang Mengmeng, Xin Pengfei, Zhang Hua, Xiang Xiaobing. The pivotal role of autophagy in bone cells: bone-related cell activity and bone metabolism[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(2): 276-282.
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[15] | 何云影, 李玲婕, 张舒淇, 李雨舟, 杨 生, 季 平. 聚丙烯酸/琼脂糖三维培养构建细胞球的方法[J]. 中国组织工程研究, 2022, 26(4): 553-559. |
References that meet the selection criteria were included, and repetitive references that are irrelevant to the objective of the review were excluded. A total of 278 articles published from 2005 to 2020 were retrieved, and 84 articles were finally included according to the inclusion criteria (Figure 1).
文题释义:#br# 自噬:当细胞面临外部环境压力(例如缺乏营养、缺氧、损伤等)时,它们可以使用溶酶体依赖性途径来破坏细胞,回收细胞器、有机物以满足自己的需求,这种现象称为自噬。#br# 骨组织:骨组织的细胞成分主要包括骨髓间充质干细胞、成骨细胞、骨细胞和破骨细胞。成骨细胞主要合成骨基质,破骨细胞具有骨吸收功能,生理状态下,骨组织的生成和吸收处于动态平衡中。#br# 中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
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