骨膜在骨折愈合及骨组织修复过程中的作用

doi:10.3969/j.issn.2095-4344.2828

中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (30): 4860-4865.doi: 10.3969/j.issn.2095-4344.2828

• 骨与关节综述 bone and joint review • 上一篇下一篇

骨膜在骨折愈合及骨组织修复过程中的作用

蒋昇源，宫智浩，宋凯凯，杜刚强，李朋，张锴

滨州医学院附属医院创伤骨科，山东省滨州市 256600

收稿日期:2020-02-14 修回日期:2020-02-24 接受日期:2020-03-25 出版日期:2020-10-28 发布日期:2020-09-22
通讯作者: 张锴，博士，教授，滨州医学院附属医院创伤骨科，山东省滨州市 256600
作者简介:蒋昇源，男，1993年生，山东省龙口市人，汉族，滨州医学院在读硕士，主要从事创伤骨科研究。

Role of periosteum in fracture healing and bone tissue repair

Jiang Shengyuan, Gong Zhihao, Song Kaikai, Du Gangqiang, Li Peng, Zhang Kai

Department of Traumatic Orthopedics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China

Received:2020-02-14 Revised:2020-02-24 Accepted:2020-03-25 Online:2020-10-28 Published:2020-09-22
Contact: Zhang Kai, MD, Professor, Department of Traumatic Orthopedics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
About author:Jiang Shengyuan, Master candidate, Department of Traumatic Orthopedics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China

摘要/Abstract

摘要：

文题释义：

骨膜：是覆盖于骨表面(除关节外)的结构复杂的结缔组织包膜，内含丰富的微血管和多种具有成骨潜能的细胞，分为内骨膜与外骨膜，通常所讲的骨膜指的是外骨膜。在骨折愈合过程中，骨膜内的骨祖细胞能够分化为具有成骨潜能的细胞，对骨折愈合有显著的促进作用。

组织工程骨膜：利用骨组织工程技术将体外培养的骨膜源细胞扩增，并吸附于某种具有良好生物相容性且易被人体组织所吸收的生物材料上，填补于骨缺损处，修复骨缺损。

背景：骨膜因含有成骨潜能的细胞而参与骨折愈合及骨组织修复的过程，其在修复骨缺损方面的作用是目前研究的热点。

目的：对骨膜在骨折愈合及骨组织修复过程中所发挥的作用进行综述。

方法：第一作者应用计算机检索1964年1月至2019年12月PubMed、中国知网数据库等中英文期刊全文数据库有关骨膜在骨折愈合及骨组织修复过程中作用的文章，英文检索词“periosteum，bone healing，periosteum cells”；中文检索词“骨膜，骨折愈合，骨膜细胞”。最终选择48篇重要文献进行综述。

结果与结论：①骨膜的完整性对于骨折愈合和骨组织的修复极其重要，因其较好的成骨性能、优质的材料学特性和屏障作用等特点被广泛应用于骨组织工程；②骨膜在牵拉成骨过程中的作用机制目前尚且存在争议，研究证实骨膜缺如并不会影响下颌骨缺损牵拉成骨的效果，但在四肢骨缺损牵拉成骨中的作用仍有待进一步研究。

ORCID: 0000-0003-4391-2360(蒋昇源)

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 骨, 骨折, 骨膜, 骨膜细胞, 成骨, 骨缺损, 综述

Abstract:

BACKGROUND: The periosteum is involved in fracture healing and bone tissue repair because it contains cells with osteogenic potential, and its role in repairing bone defects has become a focus of current research.

OBJECTIVE: To review the role of periosteum in fracture healing and bone tissue repair.

METHODS: A computer-based online search of China National Knowledge Infrastructure database and PubMed was performed for articles regarding the role of periosteum in fracture healing and bone tissue repair published from January 1964 to December 2019. Key words included “periosteum, bone healing, periosteum cells” in English and Chinese. Finally, a total of 48 articles were included to review.

RESULTS AND CONCLUSION: (1) The integrity of periosteum plays an important role in fracture healing and bone tissue repair, and has been widely used in bone tissue engineering due to its good osteogenic properties, excellent material properties and barrier effect. (2) The mechanism of periosteum in the process of distraction

ostegogenesis is still controversial. It has been confirmed that absence of periosteum does not affect the osteogenic effect of mandibular defects, but the role of periosteum in osteogenic effect of limb defects remains to be further studied.

Key words: bone, fracture, periosteum, periosteal cell, osteogenesis, bone defect, review

中图分类号:

蒋昇源, 宫智浩, 宋凯凯, 杜刚强, 李朋, 张锴. 骨膜在骨折愈合及骨组织修复过程中的作用[J]. 中国组织工程研究, 2020, 24(30): 4860-4865.

Jiang Shengyuan, Gong Zhihao, Song Kaikai, Du Gangqiang, Li Peng, Zhang Kai. Role of periosteum in fracture healing and bone tissue repair[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(30): 4860-4865.

图/表（结果） 1

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骨膜在骨折愈合及骨组织修复过程中的作用

Role of periosteum in fracture healing and bone tissue repair

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