中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (24): 3924-3930.doi: 10.3969/j.issn.2095-4344.2017.24.026

• 组织构建综述 tissue construction review • 上一篇    下一篇

基于骨-软骨交互作用探析骨关节炎发病机制及治疗策略

李广广1,郭 杨1,戴国达2,葛文杰2,马 勇1,袁 翰1,董晤讯1,蔡建平2   

  1. 1南京中医药大学骨伤研究所,江苏省南京市  2100232无锡市中医医院骨伤科,江苏省无锡市  214071
  • 修回日期:2017-05-20 出版日期:2017-08-28 发布日期:2017-08-30
  • 通讯作者: 蔡建平,博士,主任中医师。无锡市中医医院骨伤科,江苏省无锡市 214071
  • 作者简介:李广广,男,1992年生,江苏省徐州市人,汉族,南京中医药大学在读硕士。
  • 基金资助:

    江苏省科技项目合同(BK20151007);无锡市医院管理中心科研项目(YGZXM14046);无锡市卫生和计划生育委员会科研项目(Q201503);江苏省普通高校研究生科研创新计划项目(KYZZ16_0409)

Bone-cartilage crosstalk: a conversation for understanding the pathogenesis and new treatment strategy of osteoarthritis

Li Guang-guang1, Guo Yang1, Dai Guo-da2, Ge Wen-jie2 , Ma Yong1, Yuan Han1, Dong Wu-xun1, Cai Jian-ping2   

  1. 1Institute of Traumatology, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; 2Department of Traumatic Orthopedics, Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214071, Jiangsu Province, China
  • Revised:2017-05-20 Online:2017-08-28 Published:2017-08-30
  • Contact: Cai Jian-ping, M.D., Chief physician, Department of Traumatic Orthopedics, Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214071, Jiangsu Province, China
  • About author:Li Guang-guang, Studying for master’s degree, Institute of Traumatology, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Supported by:

    the Science and Technology Project of Jiangsu Province, No. BK20151007; the Research Project of the Management Center of Wuxi Hospital, No. YGZXM14046; the Research Project of the Health and Family Planning Commission of Wuxi, No. Q201503; the Postgraduate Research Innovation Program of Universities in Jiangsu Province, No. KYZZ16_0409

摘要:

文章快速阅读:

 

文题释义:
骨-软骨的交互作用:
是指骨-软骨面位于关节软骨的深层和软骨下骨之间,涵盖了潮线、钙化软骨层及软骨下骨板。骨-软骨面是一个复杂的功能单元和生物复合体,各组织之间相互影响、相互渗透。在紧密的生物力学和生物化学交互作用下,该单元的组成、结构和功能性质会发生变化。骨与软骨存在紧密联系,任一组织的改变都会影响周围的其他组织,进而导致疾病的发生。
骨关节炎:对骨关节炎的研究,多数研究者仅从骨或软骨的单方面损伤考虑。但软骨同软骨下骨的解剖结构联系密切,并在功能上构成了一个协同的整体单元。二者通过细胞间分子信号和级联的信号转导方式产生交互作用,这可能是骨关节炎发生发展的根本病机所在。

 

摘要
背景:
骨关节炎作为退行性关节疾病,软骨损伤和组织缺失不能完全解释其发病机制,骨重建的失衡以及关节内组织相互作用可能在疾病过程中有重要意义。
目的:对骨-软骨交互作用在骨关节炎的发生发展过程中产生的作用及新的治疗策略进行综述。
方法:由第一作者检索2007至2017年PubMed及中国知网等数据库收录的关于骨关节炎的发生发展与骨-软骨交互作用关系的实验研究及研究进展的文献。中文检索词分别为“骨、软骨、交互作用、骨关节炎、发病机制、细胞因子、信号通路”,英文检索词分别为“cartilage;interaction;osteoarthritis;pathogenesis;cytokines;signaling pathway”,文章从细胞因子、信号通路、新型治疗策略3个方面,对骨-软骨交互作用与骨关节炎发生发展的关系进行综述。
结果与结论:共检索到169篇文章,按纳入和排除标准对文献进行筛选,共纳入54篇文章。软骨同软骨下骨的解剖结构联系密切,骨与软骨构成了一个功能协同的整体单元。在骨关节炎发生发展过程中,骨重建异常以及新生血管数量的增加、微裂缝的形成,促进了分子信号在骨-软骨间的转位和交互作用。骨-软骨的交互作用是骨关节炎发生发展的病理中心。

 

关键词: 组织构建, 骨组织工程, 骨-软骨交互作用, 骨关节炎, 发病机制, 细胞因子, 信号通路, 生物力学, 骨重建, 治疗策略, 神经血管再生, 结构修复

Abstract:

BACKGROUND: Osteoarthritis, a degenerative joint disease, is not only a result from the breakdown of joint cartilage and underlying bone, but also an imbalance of bone remodeling and crosstalk among tissues in the joints.
OBJECTIVE: To review the effect of bone-cartilage crosstalk in the progression of osteoarthritis and its new treatment strategy.
METHODS: A computer-based search of PubMed and CNKI databases was performed for relevant literatures about the relationship between the progress of osteoarthritis and the bone-cartilage crosstalk published from 2007 to 2017. The keywords were “cartilage, interaction, osteoarthritis, pathogenesis, cytokines, signaling pathway” in English and Chinese, respectively. The relationship between the progress of osteoarthritis and the bone-cartilage crosstalk was summarized in views of cytokines, signaling pathway, and new treatment strategy.
RESULTS AND CONCLUSION: Totally 169 articles were retrieved, and finally 54 eligible papers were enrolled based on the inclusion and exclusion criteria. There is a close physical association between subchondral bone and cartilage, and the bone-cartilage interface is a functioning synergistic unit. Increased vascularization, micro-crack formation and abnormal bone remodeling may accelerate the molecules transporting from cartilage to bone in osteoarthritis. Therefore, the bone-cartilage crosstalk plays a pivotal role in the occurrence and development of osteoarthritis.

 

Key words: Tissue Engineering, Osteoarthritis, Chemokines, Receptors, Cytokine

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