中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (17): 2783-2788.doi: 10.3969/j.issn.2095-4344.2017.17.025

• 干细胞综述 stem cell review • 上一篇    

异基因造血干细胞移植后移植物抗白血病效应与移植物抗宿主病分离方法的研究现状

王炳晨1,2,江  明1,2   

  1. 1新疆医科大学第一附属医院血液病中心,新疆维吾尔自治区乌鲁木齐市  830054;2新疆维吾尔自治区血液病研究所,新疆维吾尔自治区乌鲁木齐市  830054
  • 修回日期:2017-03-25 出版日期:2017-06-18 发布日期:2017-06-29
  • 通讯作者: 江明,主任医师,教授,博士生导师。新疆医科大学第一附属医院血液病中心,新疆维吾尔自治区乌鲁木齐市 830054;新疆维吾尔自治区血液病研究所,新疆维吾尔自治区乌鲁木齐市 830054
  • 作者简介:王炳晨,男,1989年生,汉族,山东省菏泽市人,新疆医科大学在读硕士,主要从事血液病、造血干细胞移植研究。
  • 基金资助:

    国家自然科学基金(81060050)

Current status of research on separation methods of graft-versus-leukemia effect and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation 

Wang Bing-chen1, 2, Jiang Ming1, 2   

  1. 1Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China; 2Xinjiang Research Institute of Hematology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Revised:2017-03-25 Online:2017-06-18 Published:2017-06-29
  • Contact: Jiang Ming, Chief physician, Professor, Doctoral supervisor, Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China; Xinjiang Research Institute of Hematology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • About author:Wang Bing-chen, Studying for master’s degree, Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China; Xinjiang Research Institute of Hematology, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81060050

摘要:

文题释义:
移植物抗宿主病:
异体供者移植物中的T淋巴细胞对受者靶细胞发动细胞毒作用,一般认为移植后100 d以内的为急性移植物抗宿主病,移植后100 d后的为慢性移植物抗宿主病。
移植物抗白血病效应:是指与异基因造血干、祖细胞移植密切相关的移植物抗白血病功能,它的产生与移植前进行的化、放疗等预处理方案并无关联。

 

摘要
背景:
异基因造血干细胞移植的本质是免疫细胞的移植,其治疗作用主要依靠移植物抗白血病效应,但其伴随的移植物抗宿主病增加了患者的死亡率,影响疗效。目前研究者提出了多种减轻移植物抗宿主病同时增强移植物抗白血病效应的方法,但各有优缺点及争议点,故对两者之间的关系及分离方法尚需进一步深入的研究。
目的:综述异基因造血干细胞移植后减轻移植物抗宿主病而加强或不降低移植物抗白血病效应的研究现状。
方法:由第一作者检索万方、CNKI、PubMed数据库,检索时间为2000至2016年,英文检索词为“hematopoietic stem cell transplantation,graft versus leukemia,graft-versus-host disease,donor lymphocyte infusion,regulatory T cell,natural killer cell,mesenchymal stem cell”,查阅近年增强移植物抗白血病效应及减低移植物抗宿主病的相关文献。
结果与结论:最终纳入42篇文献。目前有关移植物抗白血病效应和移植物抗宿主病的关系及各自的发生机制仍不十分明确,有关两者分离方法虽多,但各有优缺点及争议点,尚未有统一的最优方案,需要进一步研究。

 

 

ORCID:0000-0003-2455-8634(王炳晨)

关键词: 干细胞, 移植, 异基因造血干细胞, 移植物抗宿主病, 移植物抗白血病效应, 供者淋巴细胞输注, 调节性T细胞, 间充质干细胞, NK细胞, 国家自然科学基金

Abstract:

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the essence of immune cell transplantation, its curative effect mainly depends on graft-versus-leukemia (GVL) effect, but its accompanying graft-versus-host disease (GVHD) can increase mortality and affect the therapeutic efficacy. Until now, researchers have proposed a variety of ways to reduce GVHD but enhance or maintain GVL. However, these methods have their own advantages, disadvantages and controversial points. So their relationship and separation methods still need further studies.
OBJECTIVE: To summarize the current status of research about separation methods of GVHD and GVL after allo-HSCT.
METHODS: Using “hematopoietic stem cell transplantation, graft versus leukemia, graft-versus-host disease, donor lymphocyte infusion, regulatory T cell, natural killer cell, mesenchymal stem cell” as key words, we retrieved Wanfang, CNKI and PubMed databases (2000-2016) by computer.
RESULTS AND CONCLUSION: We finally reviewed 41 literatures about enhancing GVL and reducing GVHD in recent years. At present, the relationship between GVHD and GVL, and their respective mechanisms are still unclear. There are many methods to separate GVHD and GVL, but these methods have their own advantages and disadvantages. The best solution has not yet been unified, and still needs further study.

 

 

Key words: Tissue Engineering, Stem Cells, Leukemia

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